coca
Erythroxylum coca · Accepted scientific name
Scientific literature: Very Extensive (696 studies) · ★★★★★
Coca, scientifically known as Erythroxylum coca, is a perennial shrub native to the Andean regions of South America. Historically revered by indigenous cultures, its leaves have been used for centuries in traditional medicine to alleviate fatigue, hunger, and altitude sickness, serving as a profound cultural and botanical cornerstone.
- Family
- Erythroxylaceae
- Native range
- Africa
- Parts used
- Leaf
- Common names
- Not available
- Scientific synonyms
- Not available
Names and Synonyms
Scientific Names
Accepted name
Erythroxylum cocaRegional and Traditional Names
Spanish:
- Erythroxylum bolivianum
- Coca
- Hayo
- Erythroxylum chilpei
German:
- Cocastrauch
- Kokablatt
- Kokastrauch
- Cocastrauch
French:
- coca
- Erythroxylon coca
Sources: Wikidata, Catalogue of Life
Taxonomical Classification
This plant belongs to the kingdom Plantae and the phylum Streptophyta, falling under the class Equisetopsida and subclass Magnoliidae. It is categorized within the order Malpighiales and the family Erythroxylaceae. Ultimately, its specific taxonomic designation is found within the genus Erythroxylum.
| Rank | Classification |
|---|---|
| Kingdom | Plantae |
| Phylum | Streptophyta |
| Class | Equisetopsida |
| Subclass | Magnoliidae |
| Order | Malpighiales |
| Family | Erythroxylaceae |
| Genus | Erythroxylum |
Sources: The World Checklist of Vascular Plants (WCVP)
Distribution
This plant exhibits a diverse geographical distribution spanning across multiple continents. In West Tropical Africa, its presence is noted in Guinea-Bissau, while it also inhabits the West-Central Tropical Africa regions of Cameroon and the Gulf of Guinea Islands. Moving toward East Tropical Africa, the species can be found in Tanzania. Additionally, its range extends into Eastern Asia, specifically within the Kazan-retto region. These varied locations demonstrate the wide environmental adaptability of the species.
| Region | Area |
|---|---|
| West Tropical Africa | Guinea-Bissau |
| West-Central Tropical Africa | Cameroon |
| West-Central Tropical Africa | Gulf of Guinea Is. |
| East Tropical Africa | Tanzania |
| Eastern Asia | Kazan-retto |
| Indian Subcontinent | Assam |
| Northwestern Pacific | Caroline Is. |
| Western South America | Bolivia |
| Western South America | Colombia |
| Western South America | Ecuador |
Sources: The World Checklist of Vascular Plants (WCVP)
Botanical Identification
Ecology
The ecology of Erythroxylum coca is strictly defined by specific altitudinal parameters within its native tropical habitats. This species thrives within a precise elevational range, beginning at a minimum altitude of 120 m AMSL and extending up to a maximum of 500 m AMSL. Throughout its natural distribution, the plant maintains a mean elevation of approximately 400 m AMSL, a characteristic that dictates the specific climatic and environmental conditions it requires to flourish.
- Elevational range max:
- 500 m AMSL
- Elevational range mean:
- 400 m AMSL
- Elevational range min:
- 120 m AMSL
Life history
The life history of Erythroxylum coca is characterized by its status as a perennial species, allowing the plant to persist in its environment over many years. As a long-lived shrub or small tree, it undergoes a continuous cycle of vegetative growth and reproductive phases, rather than completing its life cycle within a single season. This perennial nature enables the plant to establish a robust root system and a woody structure that can withstand seasonal variations, provided the environmental conditions remain conducive to its survival. Throughout its extended lifespan, the plant undergoes periodic flowering and fruiting cycles, contributing to the ongoing regeneration of its population through seed dispersal.
- Lifecycle :
- perennial
Morphology
The morphology of Erythroxylum coca is characterized by a woody growth form, primarily manifesting as a shrub. It is a terrestrial plant that functions as an independent organism, showing no parasitic behavior. In terms of stature, it typically reaches an average plant height of approximately 1.5 m. Structurally, the plant is self-supporting rather than acting as a climber, liana, or vine, and it does not exhibit any epiphytic tendencies, maintaining a strictly terrestrial existence.
- Aquatic :
- terrestrial
- Climber :
- self-supporting
- Epiphyte :
- terrestrial
- Growth form :
- shrub
- Parasite :
- independent
- Plant height mean:
- 1.5 m
- Woodiness :
- woody
Physiology
The physiology of Erythroxylum coca is characterized by its specialized metabolic processes and adaptive strategies for survival in tropical and subtropical environments. As a perennial shrub, its physiological activity is heavily influenced by light intensity and moisture availability, driving efficient photosynthetic pathways to support rapid growth in nutrient-competitive habitats. A critical aspect of its nutrient acquisition profile is its relationship with soil chemistry; specifically, regarding nitrogen management, it is not a nitrogen fixer (trait_1: Nitrogen fixer, trait_value: no). Unlike many other tropical shrubs that form symbiotic relationships with diazotrophic bacteria to convert atmospheric nitrogen, Erythroxylum coca relies on the uptake of available nitrates and ammonium from the soil through its root system. This reliance necessitates nutrient-rich substrates to sustain its high metabolic demands, particularly for the biosynthesis of its complex secondary metabolites, such as alkaloids. Furthermore, the plant exhibits robust transpiration mechanisms and osmotic regulation to manage water potential, ensuring cellular stability during fluctuations in humidity and temperature.
- Nitrogen fixer :
- no
Reproduction
The reproduction of Erythroxylum coca is a biological process characterized by specific seed morphology and standardized physical dimensions. The reproductive success of the species relies on the production of seeds that exhibit remarkable consistency in their physical properties. Based on empirical data, the seed mass of this plant is highly uniform, with a recorded mean seed mass of 0.1181 g. This consistency is reflected in the extreme narrowness of its size distribution, as both the maximum and minimum observed seed mass values are also 0.1181 g. Such precise uniformity in seed mass suggests a highly regulated developmental process during the maturation of the fruit, ensuring that each seed possesses a standardized amount of nutrient reserves for potential germination.
- Seed mass mean:
- 0.1181 g
Sources: Global Inventory of Floras and Traits (GIFT)
Plant Parts
Erythroxylum coca has 1 reported plant parts identified across 4 scientific publications and several other databases that are studied for medicinal purposes. The most consistently reported plant part include leaf.
| Plant part | Supporting sources | Consensus |
|---|---|---|
| Leaf | 4 supporting sources | ★★☆☆☆ |
Leaf
- Phytochemistry
- Journal of ethnopharmacology
- Bulletin on narcotics
- Food and nutrition bulletin
Chemicals
Erythroxylum coca has 103 reported phytochemicals identified across 4 scientific publications and several other databases. The most consistently reported chemicals include cocaine, benzoylecgonine, Ecgonine methyl ester, Benzoyltropine, CALCIUM.
| Chemical | Supporting sources | Consensus |
|---|---|---|
| cocaine | 25 supporting sources | ★★★★★ |
| benzoylecgonine | 4 supporting sources | ★★☆☆☆ |
| Ecgonine methyl ester | 3 supporting sources | ★★☆☆☆ |
| Benzoyltropine | 2 supporting sources | ★☆☆☆☆ |
| CALCIUM | 2 supporting sources | ★☆☆☆☆ |
| Coca | 2 supporting sources | ★☆☆☆☆ |
| Cuscohygrine | 2 supporting sources | ★☆☆☆☆ |
| Hygrine | 2 supporting sources | ★☆☆☆☆ |
| IRON | 2 supporting sources | ★☆☆☆☆ |
| MAGNESIUM | 2 supporting sources | ★☆☆☆☆ |
cocaine
- Dr. Duke
- Bulletin on narcotics
- Journal of analytical toxicology
- Pharmacology, biochemistry, and behavior
- NIDA research monograph
View 20 additional sources
- Journal of ethnopharmacology
- Phytochemistry
- The American journal of drug and alcohol abuse
- Arquivos brasileiros de oftalmologia
- Forensic science international
- Ciba Foundation symposium
- Annales de medecine interne
- Polish journal of pharmacology
- Berichte zur Wissenschaftsgeschichte
- Journal of forensic sciences
- Journal of applied physiology (Bethesda, Md. : 1985)
- Journal of chromatography. A
- Canadian Medical Association journal
- Journal of ethnicity in substance abuse
- Organic letters
- Emergency medicine international
- Toxicology and applied pharmacology
- Journal of natural products
- Food and nutrition bulletin
- Proceedings of the National Academy of Sciences of the United States of America
benzoylecgonine
- Dr. Duke
- Journal of ethnopharmacology
- Journal of analytical toxicology
- Forensic science international
Ecgonine methyl ester
- Journal of analytical toxicology
- Journal of ethnopharmacology
- Forensic science international
Benzoyltropine
- Dr. Duke
- Journal of ethnopharmacology
CALCIUM
- Dr. Duke
- Food and nutrition bulletin
Coca
- American journal of physical anthropology
- Tropenmedizin und Parasitologie
Cuscohygrine
- Dr. Duke
- Journal of ethnopharmacology
Hygrine
- Dr. Duke
- Journal of ethnopharmacology
IRON
- Dr. Duke
- Food and nutrition bulletin
MAGNESIUM
- Dr. Duke
- Food and nutrition bulletin
Activities
Erythroxylum coca has 496 reported activities identified across 4 scientific publications and several other databases. The most consistently reported activities include Antidepressant, Insecticide, Stimulant, 11B-HSD-Inhibitor, 5-Alpha-Reductase-Inhibitor.
| Activity | Supporting sources | Consensus |
|---|---|---|
| Antidepressant | 3 supporting sources | ★★☆☆☆ |
| Insecticide | 2 supporting sources | ★☆☆☆☆ |
| Stimulant | 2 supporting sources | ★☆☆☆☆ |
| 11B-HSD-Inhibitor | 1 supporting sources | ★☆☆☆☆ |
| 5-Alpha-Reductase-Inhibitor | 1 supporting sources | ★☆☆☆☆ |
| 5-HT-Inhibitor | 1 supporting sources | ★☆☆☆☆ |
| 5-Lipoxygenase-Inhibitor | 1 supporting sources | ★☆☆☆☆ |
| ACE-Inhibitor | 1 supporting sources | ★☆☆☆☆ |
| ANS-Paralytic | 1 supporting sources | ★☆☆☆☆ |
| ANS-Stimulant | 1 supporting sources | ★☆☆☆☆ |
Antidepressant
- Dr. Duke
- Journal of ethnopharmacology
- The American journal of drug and alcohol abuse
Insecticide
- Dr. Duke
- Proceedings of the National Academy of Sciences of the United States of America
Stimulant
- The American journal of drug and alcohol abuse
- Systematic biology
11B-HSD-Inhibitor
- Dr. Duke
5-Alpha-Reductase-Inhibitor
- Dr. Duke
5-HT-Inhibitor
- Dr. Duke
5-Lipoxygenase-Inhibitor
- Dr. Duke
ACE-Inhibitor
- Dr. Duke
ANS-Paralytic
- Dr. Duke
ANS-Stimulant
- Dr. Duke
Conditions
Erythroxylum coca has 14 reported investigations on conditions identified across 4 scientific publications and several other databases. The most consistently reported conditions include antidepressant, motion sickness, asthma, cachexia, coca.
| Condition | Supporting sources | Consensus |
|---|---|---|
| Antidepressant | 2 supporting sources | ★☆☆☆☆ |
| Motion sickness | 2 supporting sources | ★☆☆☆☆ |
| Asthma | 1 supporting sources | ★☆☆☆☆ |
| Cachexia | 1 supporting sources | ★☆☆☆☆ |
| Coca | 1 supporting sources | ★☆☆☆☆ |
| Cocaine addiction | 1 supporting sources | ★☆☆☆☆ |
| Cocaine dependence | 1 supporting sources | ★☆☆☆☆ |
| Diabetes mellitus | 1 supporting sources | ★☆☆☆☆ |
| Hypoglycemia | 1 supporting sources | ★☆☆☆☆ |
| Local anesthetic | 1 supporting sources | ★☆☆☆☆ |
Antidepressant
- Journal of ethnopharmacology
- The American journal of drug and alcohol abuse
Motion sickness
- Journal of ethnopharmacology
- The American journal of drug and alcohol abuse
Asthma
- Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie
Cachexia
- Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie
Coca
- Journal of toxicology and environmental health. Part A
Cocaine addiction
- Canadian Medical Association journal
Cocaine dependence
- Annales de medecine interne
Diabetes mellitus
- Journal of ethnopharmacology
Hypoglycemia
- Journal of ethnopharmacology
Local anesthetic
- Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie
Preparations
Erythroxylum coca has 3 reported preparations identified across 4 scientific publications and several other databases. The most consistently reported preparations include air-or heat-dried, coca leaf extract, homeopathic medicine.
| Preparation | Supporting sources | Consensus |
|---|---|---|
| Air-or heat-dried | 1 supporting sources | ★☆☆☆☆ |
| Coca leaf extract | 1 supporting sources | ★☆☆☆☆ |
| Homeopathic medicine | 1 supporting sources | ★☆☆☆☆ |
Air-or heat-dried
- Journal of ethnopharmacology
Coca leaf extract
- Journal of ethnopharmacology
Homeopathic medicine
- Phytochemistry