Cynanchum wilfordii
Cynanchum wilfordii · Accepted scientific name
Scientific literature: Very Sparse (38 studies) · ★☆☆☆☆
, scientifically known as Cynanchum wilfordii, is a highly valued medicinal herb in traditional East Asian medicine. Commonly referred to as Wilford's swallowwort, it is rich in bioactive compounds like coumarins and alkaloids. Research suggests its potent antioxidant, anti-inflammatory, and anti-tumor properties make it a significant subject for modern pharmacology.
- Family
- Apocynaceae
- Native range
- Asia-Temperate
- Parts used
- Root · Stem
- Common names
- Not available
- Scientific synonyms
- Vincetoxicum Wilfordii · Seutera Wilfordii · 1 more
Names and Synonyms
Scientific Names
Accepted name
Cynanchum wilfordiiSynonyms
- Vincetoxicum wilfordii
- Seutera wilfordii
- Cynoctonum wilfordii
Sources: Wikidata
Taxonomical Classification
This plant belongs to the kingdom Plantae within the phylum Streptophyta and the class Equisetopsida. It is further classified under the subclass Magnoliidae and the order Gentianales, falling into the family Apocynaceae. Ultimately, its scientific identity is defined by the genus Cynanchum.
| Rank | Classification |
|---|---|
| Kingdom | Plantae |
| Phylum | Streptophyta |
| Class | Equisetopsida |
| Subclass | Magnoliidae |
| Order | Gentianales |
| Family | Apocynaceae |
| Genus | Cynanchum |
Sources: The World Checklist of Vascular Plants (WCVP)
Distribution
This plant exhibits a wide geographical distribution across several distinct regions of East Asia. In the Russian Far East, its presence is specifically noted within the Primorye territory. Moving into China, the species can be found extensively throughout the Manchuria region. It also occupies significant portions of China South-Central and China North-Central. Furthermore, the plant's range extends into the diverse landscapes of China Southeast.
| Region | Area |
|---|---|
| Russian Far East | Primorye |
| China | China South-Central |
| China | Manchuria |
| China | China North-Central |
| China | China Southeast |
| China | Tibet |
| Eastern Asia | Japan |
| Eastern Asia | Korea |
Sources: The World Checklist of Vascular Plants (WCVP)
Botanical Identification
Ecology
The ecology of Cynanchum wilfordii is characterized by its preference for specific montane environments, where it typically thrives in mountains and stony places. This species occupies a distinct altitudinal niche, with its elevational range spanning from a minimum of 800 m AMSL to a maximum of 1300 m AMSL. Within this vertical distribution, the plant maintains a mean elevation of approximately 1050 m AMSL, suggesting a specialization for mid-to-high altitude terrains where rocky substrates and mountain climates provide its primary growing conditions.
- Elevational range max:
- 1300 m AMSL
- Elevational range mean:
- 1050 m AMSL
- Elevational range min:
- 800 m AMSL
- Habitat :
- mountains, stony places
Life history
The life history of Cynanchum wilfordii is characterized by its status as a perennial herb, allowing it to persist through multiple growing seasons. As a climbing or creeping perennial, the plant establishes a robust root system that serves as a primary storage organ for nutrients, facilitating its long-term survival and ability to regrow annually. Throughout its life cycle, it undergoes seasonal stages of vegetative growth, where it utilizes its twining stems to climb surrounding vegetation, followed by a reproductive phase involving the flowering and seeding processes. This perennial nature ensures that the plant can withstand environmental fluctuations, maintaining a continuous presence in its natural habitat through repeated cycles of development.
- Lifecycle :
- perennial
Morphology
The morphology of Cynanchum wilfordii is characterized by its growth form as a herbaceous plant, specifically functioning as a perennial climbing herb. In terms of its structural composition, the plant exhibits a non-woody nature, possessing flexible, twining stems that allow it to ascend through surrounding vegetation. These stems are slender and lack significant lignification, consistent with its non-woody classification.
- Growth form :
- herb
- Woodiness :
- non-woody
Physiology
The physiology of Cynanchum wilfordii is characterized by distinct morphological dimensions of its foliage, which serve as key indicators of its vegetative development and surface area for photosynthetic activity. The leaves exhibit a specific range of size, with a mean leaf length of 5.5 cm and a minimum length of 5 cm, reaching a maximum capacity of 6 cm. Correspondingly, the leaf width displays significant variability, ranging from a minimum of 2 cm to a maximum of 4 cm, with a calculated mean width of 3 cm. These dimensional parameters reflect the plant's structural adaptations for light interception and gas exchange, essential for its metabolic processes and the synthesis of its bioactive compounds.
- Leaf length max:
- 6 cm
- Leaf length mean:
- 5.5 cm
- Leaf length min:
- 5 cm
- Leaf width max:
- 4 cm
- Leaf width mean:
- 3 cm
- Leaf width min:
- 2 cm
Reproduction
The reproduction of Cynanchum wilfordii is characterized by a specific flowering period and distinct fruit morphology. The plant's flowering cycle is concentrated in the month of July, with both the flowering start and flowering end occurring during this time. Following pollination, the plant produces elongated fruits that exhibit very little variation in dimension. The fruits typically maintain a consistent length of approximately 12 cm, with both the minimum, mean, and maximum recorded lengths staying at this value. Similarly, the fruit width is uniform, measuring approximately 1 cm, which is reflected across its minimum, mean, and maximum width measurements.
- Flowering time :
- Jul
- Fruit length max:
- 12 cm
- Fruit width max:
- 1 cm
Sources: Global Inventory of Floras and Traits (GIFT)
Plant Parts
Cynanchum wilfordii has 2 reported plant parts identified across 6 scientific publications and several other databases that are studied for medicinal purposes. The most consistently reported plant part include root, stem.
| Plant part | Supporting sources | Consensus |
|---|---|---|
| Root | 5 supporting sources | ★★★☆☆ |
| Stem | 1 supporting sources | ★☆☆☆☆ |
Root
- Biological & pharmaceutical bulletin
- Frontiers in plant science
- Journal of natural products
- Journal of pharmaceutical and biomedical analysis
- International journal of molecular medicine
Stem
- Biological & pharmaceutical bulletin
Chemicals
Cynanchum wilfordii has 11 reported phytochemicals identified across 6 scientific publications and several other databases. The most consistently reported chemicals include cynandione A, CWE, CYNAURICUOSIDE A, Cynandione B, Gagaminine.
| Chemical | Supporting sources | Consensus |
|---|---|---|
| cynandione A | 5 supporting sources | ★★★☆☆ |
| CWE | 1 supporting sources | ★☆☆☆☆ |
| CYNAURICUOSIDE A | 1 supporting sources | ★☆☆☆☆ |
| Cynandione B | 1 supporting sources | ★☆☆☆☆ |
| Gagaminine | 1 supporting sources | ★☆☆☆☆ |
| Gallic acid | 1 supporting sources | ★☆☆☆☆ |
| P-HYDROXYACETOPHENONE | 1 supporting sources | ★☆☆☆☆ |
| Steroidal alkaloid | 1 supporting sources | ★☆☆☆☆ |
| Wilfoside C1N | 1 supporting sources | ★☆☆☆☆ |
| Wilfoside K1N | 1 supporting sources | ★☆☆☆☆ |
cynandione A
- Biological & pharmaceutical bulletin
- The Journal of pharmacy and pharmacology
- Journal of pharmaceutical and biomedical analysis
- International journal of molecular medicine
- Journal of neuroscience research
CWE
- Nutrition research (New York, N.Y.)
CYNAURICUOSIDE A
- Journal of natural products
Cynandione B
- Journal of pharmaceutical and biomedical analysis
Gagaminine
- Biological & pharmaceutical bulletin
Gallic acid
- Molecules (Basel, Switzerland)
P-HYDROXYACETOPHENONE
- International journal of molecular medicine
Steroidal alkaloid
- Biological & pharmaceutical bulletin
Wilfoside C1N
- Journal of natural products
Wilfoside K1N
- Journal of natural products
Activities
Cynanchum wilfordii has 2 reported activities identified across 6 scientific publications and several other databases. The most consistently reported activities include Antioxidant, Neuroprotective.
| Activity | Supporting sources | Consensus |
|---|---|---|
| Antioxidant | 1 supporting sources | ★☆☆☆☆ |
| Neuroprotective | 1 supporting sources | ★☆☆☆☆ |
Antioxidant
- Biological & pharmaceutical bulletin
Neuroprotective
- Journal of neuroscience research
Medicinal Uses
Cynanchum wilfordii has 10 reported medicinal uses identified across 6 scientific publications and several other databases. The most consistently reported uses include apoptosis, atherosclerosis, inflammation, multidrug-resistance, neurodegenerative disorders.
Most Reported Uses
| Use | Sources | Consensus |
|---|---|---|
| apoptosis | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (and other 1 sources) | ★☆☆☆☆ |
| atherosclerosis | International journal of molecular medicine (and other 1 sources) | ★☆☆☆☆ |
| inflammation | Nutrition research (New York, N.Y.) (and other 1 sources) | ★☆☆☆☆ |
| multidrug-resistance | Journal of natural products (and other 1 sources) | ★☆☆☆☆ |
| neurodegenerative disorders | Journal of neuroscience research (and other 1 sources) | ★☆☆☆☆ |
| nonalcoholic fatty liver disease | Nutrition research (New York, N.Y.) (and other 1 sources) | ★☆☆☆☆ |
| obesity | Pharmaceutical biology (and other 1 sources) | ★☆☆☆☆ |
| oxidative stress | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (and other 1 sources) | ★☆☆☆☆ |
| senile dementia | Journal of neuroscience research (and other 1 sources) | ★☆☆☆☆ |
| ulcerative colitis | Nan fang yi ke da xue xue bao = Journal of Southern Medical University (and other 1 sources) | ★☆☆☆☆ |
Preparations
| Preparations | Sources | Consensus |
|---|---|---|
| Calli | Biological & pharmaceutical bulletin (and other 1 sources) | ★☆☆☆☆ |
| Chinese medicine extracts | Molecules (Basel, Switzerland) (and other 1 sources) | ★☆☆☆☆ |
| Cynanchum wilfordii alcoholic extracts | Nan fang yi ke da xue xue bao = Journal of Southern Medical University (and other 1 sources) | ★☆☆☆☆ |
| Cynanchum wilfordii ethanol extract | Nan fang yi ke da xue xue bao = Journal of Southern Medical University (and other 1 sources) | ★☆☆☆☆ |
| Cynanchum wilfordii extract (CWE) | Nutrition research (New York, N.Y.) (and other 1 sources) | ★☆☆☆☆ |
| ethanol root extract | International journal of molecular medicine (and other 1 sources) | ★☆☆☆☆ |
| in vitro culture | Biological & pharmaceutical bulletin (and other 1 sources) | ★☆☆☆☆ |
| methanol extracts | Molecules (Basel, Switzerland) (and other 1 sources) | ★☆☆☆☆ |
| methanol-soluble extracts of the roots | Journal of natural products (and other 1 sources) | ★☆☆☆☆ |
| roots | Journal of pharmaceutical and biomedical analysis (and other 1 sources) | ★☆☆☆☆ |