Cynanchum wilfordii

Cynanchum wilfordii · Accepted scientific name

Scientific literature: Very Sparse (38 studies) · ★☆☆☆☆

, scientifically known as Cynanchum wilfordii, is a highly valued medicinal herb in traditional East Asian medicine. Commonly referred to as Wilford's swallowwort, it is rich in bioactive compounds like coumarins and alkaloids. Research suggests its potent antioxidant, anti-inflammatory, and anti-tumor properties make it a significant subject for modern pharmacology.

Family
Apocynaceae
Native range
Asia-Temperate
Parts used
Root · Stem
Common names
Not available
Scientific synonyms
Vincetoxicum Wilfordii · Seutera Wilfordii · 1 more

Names and Synonyms

Scientific Names

Accepted name

Cynanchum wilfordii

Synonyms

Sources: Wikidata

Taxonomical Classification

This plant belongs to the kingdom Plantae within the phylum Streptophyta and the class Equisetopsida. It is further classified under the subclass Magnoliidae and the order Gentianales, falling into the family Apocynaceae. Ultimately, its scientific identity is defined by the genus Cynanchum.

Rank Classification
Kingdom Plantae
Phylum Streptophyta
Class Equisetopsida
Subclass Magnoliidae
Order Gentianales
Family Apocynaceae
Genus Cynanchum

Sources: The World Checklist of Vascular Plants (WCVP)

Distribution

This plant exhibits a wide geographical distribution across several distinct regions of East Asia. In the Russian Far East, its presence is specifically noted within the Primorye territory. Moving into China, the species can be found extensively throughout the Manchuria region. It also occupies significant portions of China South-Central and China North-Central. Furthermore, the plant's range extends into the diverse landscapes of China Southeast.

Region Area
Russian Far East Primorye
China China South-Central
China Manchuria
China China North-Central
China China Southeast
China Tibet
Eastern Asia Japan
Eastern Asia Korea

Sources: The World Checklist of Vascular Plants (WCVP)

Botanical Identification

Ecology

The ecology of Cynanchum wilfordii is characterized by its preference for specific montane environments, where it typically thrives in mountains and stony places. This species occupies a distinct altitudinal niche, with its elevational range spanning from a minimum of 800 m AMSL to a maximum of 1300 m AMSL. Within this vertical distribution, the plant maintains a mean elevation of approximately 1050 m AMSL, suggesting a specialization for mid-to-high altitude terrains where rocky substrates and mountain climates provide its primary growing conditions.

Elevational range max:
1300 m AMSL
Elevational range mean:
1050 m AMSL
Elevational range min:
800 m AMSL
Habitat :
mountains, stony places

Life history

The life history of Cynanchum wilfordii is characterized by its status as a perennial herb, allowing it to persist through multiple growing seasons. As a climbing or creeping perennial, the plant establishes a robust root system that serves as a primary storage organ for nutrients, facilitating its long-term survival and ability to regrow annually. Throughout its life cycle, it undergoes seasonal stages of vegetative growth, where it utilizes its twining stems to climb surrounding vegetation, followed by a reproductive phase involving the flowering and seeding processes. This perennial nature ensures that the plant can withstand environmental fluctuations, maintaining a continuous presence in its natural habitat through repeated cycles of development.

Lifecycle :
perennial

Morphology

The morphology of Cynanchum wilfordii is characterized by its growth form as a herbaceous plant, specifically functioning as a perennial climbing herb. In terms of its structural composition, the plant exhibits a non-woody nature, possessing flexible, twining stems that allow it to ascend through surrounding vegetation. These stems are slender and lack significant lignification, consistent with its non-woody classification.

Growth form :
herb
Woodiness :
non-woody

Physiology

The physiology of Cynanchum wilfordii is characterized by distinct morphological dimensions of its foliage, which serve as key indicators of its vegetative development and surface area for photosynthetic activity. The leaves exhibit a specific range of size, with a mean leaf length of 5.5 cm and a minimum length of 5 cm, reaching a maximum capacity of 6 cm. Correspondingly, the leaf width displays significant variability, ranging from a minimum of 2 cm to a maximum of 4 cm, with a calculated mean width of 3 cm. These dimensional parameters reflect the plant's structural adaptations for light interception and gas exchange, essential for its metabolic processes and the synthesis of its bioactive compounds.

Leaf length max:
6 cm
Leaf length mean:
5.5 cm
Leaf length min:
5 cm
Leaf width max:
4 cm
Leaf width mean:
3 cm
Leaf width min:
2 cm

Reproduction

The reproduction of Cynanchum wilfordii is characterized by a specific flowering period and distinct fruit morphology. The plant's flowering cycle is concentrated in the month of July, with both the flowering start and flowering end occurring during this time. Following pollination, the plant produces elongated fruits that exhibit very little variation in dimension. The fruits typically maintain a consistent length of approximately 12 cm, with both the minimum, mean, and maximum recorded lengths staying at this value. Similarly, the fruit width is uniform, measuring approximately 1 cm, which is reflected across its minimum, mean, and maximum width measurements.

Flowering time :
Jul
Fruit length max:
12 cm
Fruit width max:
1 cm

Sources: Global Inventory of Floras and Traits (GIFT)

Plant Parts

Cynanchum wilfordii has 2 reported plant parts identified across 6 scientific publications and several other databases that are studied for medicinal purposes. The most consistently reported plant part include root, stem.

Plant parts reported in Cynanchum wilfordii
Plant part Supporting sources Consensus
Root 5 supporting sources ★★★☆☆
Stem 1 supporting sources ★☆☆☆☆

Root

  1. Biological & pharmaceutical bulletin
  2. Frontiers in plant science
  3. Journal of natural products
  4. Journal of pharmaceutical and biomedical analysis
  5. International journal of molecular medicine

Stem

  1. Biological & pharmaceutical bulletin

Chemicals

Cynanchum wilfordii has 11 reported phytochemicals identified across 6 scientific publications and several other databases. The most consistently reported chemicals include cynandione A, CWE, CYNAURICUOSIDE A, Cynandione B, Gagaminine.

Chemicals reported in Cynanchum wilfordii
Chemical Supporting sources Consensus
cynandione A 5 supporting sources ★★★☆☆
CWE 1 supporting sources ★☆☆☆☆
CYNAURICUOSIDE A 1 supporting sources ★☆☆☆☆
Cynandione B 1 supporting sources ★☆☆☆☆
Gagaminine 1 supporting sources ★☆☆☆☆
Gallic acid 1 supporting sources ★☆☆☆☆
P-HYDROXYACETOPHENONE 1 supporting sources ★☆☆☆☆
Steroidal alkaloid 1 supporting sources ★☆☆☆☆
Wilfoside C1N 1 supporting sources ★☆☆☆☆
Wilfoside K1N 1 supporting sources ★☆☆☆☆

cynandione A

  1. Biological & pharmaceutical bulletin
  2. The Journal of pharmacy and pharmacology
  3. Journal of pharmaceutical and biomedical analysis
  4. International journal of molecular medicine
  5. Journal of neuroscience research

CWE

  1. Nutrition research (New York, N.Y.)

CYNAURICUOSIDE A

  1. Journal of natural products

Cynandione B

  1. Journal of pharmaceutical and biomedical analysis

Gagaminine

  1. Biological & pharmaceutical bulletin

Gallic acid

  1. Molecules (Basel, Switzerland)

P-HYDROXYACETOPHENONE

  1. International journal of molecular medicine

Steroidal alkaloid

  1. Biological & pharmaceutical bulletin

Wilfoside C1N

  1. Journal of natural products

Wilfoside K1N

  1. Journal of natural products

Activities

Cynanchum wilfordii has 2 reported activities identified across 6 scientific publications and several other databases. The most consistently reported activities include Antioxidant, Neuroprotective.

Activities reported in Cynanchum wilfordii
Activity Supporting sources Consensus
Antioxidant 1 supporting sources ★☆☆☆☆
Neuroprotective 1 supporting sources ★☆☆☆☆

Antioxidant

  1. Biological & pharmaceutical bulletin

Neuroprotective

  1. Journal of neuroscience research

Medicinal Uses

Cynanchum wilfordii has 10 reported medicinal uses identified across 6 scientific publications and several other databases. The most consistently reported uses include apoptosis, atherosclerosis, inflammation, multidrug-resistance, neurodegenerative disorders.

Most Reported Uses

Use Sources Consensus
apoptosis Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (and other 1 sources) ★☆☆☆☆
atherosclerosis International journal of molecular medicine (and other 1 sources) ★☆☆☆☆
inflammation Nutrition research (New York, N.Y.) (and other 1 sources) ★☆☆☆☆
multidrug-resistance Journal of natural products (and other 1 sources) ★☆☆☆☆
neurodegenerative disorders Journal of neuroscience research (and other 1 sources) ★☆☆☆☆
nonalcoholic fatty liver disease Nutrition research (New York, N.Y.) (and other 1 sources) ★☆☆☆☆
obesity Pharmaceutical biology (and other 1 sources) ★☆☆☆☆
oxidative stress Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (and other 1 sources) ★☆☆☆☆
senile dementia Journal of neuroscience research (and other 1 sources) ★☆☆☆☆
ulcerative colitis Nan fang yi ke da xue xue bao = Journal of Southern Medical University (and other 1 sources) ★☆☆☆☆

Preparations

Preparations Sources Consensus
Calli Biological & pharmaceutical bulletin (and other 1 sources) ★☆☆☆☆
Chinese medicine extracts Molecules (Basel, Switzerland) (and other 1 sources) ★☆☆☆☆
Cynanchum wilfordii alcoholic extracts Nan fang yi ke da xue xue bao = Journal of Southern Medical University (and other 1 sources) ★☆☆☆☆
Cynanchum wilfordii ethanol extract Nan fang yi ke da xue xue bao = Journal of Southern Medical University (and other 1 sources) ★☆☆☆☆
Cynanchum wilfordii extract (CWE) Nutrition research (New York, N.Y.) (and other 1 sources) ★☆☆☆☆
ethanol root extract International journal of molecular medicine (and other 1 sources) ★☆☆☆☆
in vitro culture Biological & pharmaceutical bulletin (and other 1 sources) ★☆☆☆☆
methanol extracts Molecules (Basel, Switzerland) (and other 1 sources) ★☆☆☆☆
methanol-soluble extracts of the roots Journal of natural products (and other 1 sources) ★☆☆☆☆
roots Journal of pharmaceutical and biomedical analysis (and other 1 sources) ★☆☆☆☆