Cyclocarya paliurus

What's the taxonomical classification of Cyclocarya paliurus?

Cyclocarya paliurus belongs to the kingdom Plantae and is classified within the phylum Streptophyta. As a member of the class Equisetopsida and the subclass Magnoliidae, it follows the taxonomic lineage of the order Fagales. It is further nested within the family Juglandaceae, which places it among a diverse group of woody plants. Specifically, this plant is identified by the genus Cyclocarya and is distinguished as the species paliurus.

Taxonomic Rank Classification
Kingdom Plantae
Phylum Streptophyta
Class Equisetopsida
Subclass Magnoliidae
Order Fagales
Family Juglandaceae
Genus Cyclocarya
Species paliurus
Evidence Level: ★★★★☆

What are the morphological characteristics of this plant?

Cyclocarya paliurus has alternate, simple, and elliptic to oblong leaves that are typically leathery in texture with entire margins and pinnate venation. The foliage is characterized by a dark green upper surface and a slightly paler underside, often measuring several centimeters in length. Its woody stems exhibit a smooth to slightly lenticellate bark structure common to many members of the Sapindaceae family. The reproductive structures include small, inconspicuous flowers that eventually develop into distinctive drupaceous fruits. These fruits are characterized by a fleshy part surrounding a single seed, which is a defining feature of its morphological profile.

Evidence Level: ★☆☆☆☆

What is the geographical distribution of this plant?

This plant is native to the tropical and subtropical regions of South America, specifically spanning across Brazil, Paraguay, Uruguay, and northern Argentina. It is commonly found inhabiting various environments such as gallery forests, riparian zones, and seasonally flooded savannas. The distribution is often dictated by the availability of moisture, as it tends to thrive near watercourses and in humid lowlands. Within these territories, the species occupies specific ecological niches where soil moisture remains relatively consistent. This localized presence makes it a characteristic component of certain South American biomes.

Evidence Level: ★☆☆☆☆

How is this plant cultivated?

This plant requires well-drained, sandy or loamy soil and full sunlight to thrive in tropical or subtropical climates.

It is typically propagated through seeds that must be sown in warm, moist conditions to ensure germination. Regular watering is essential during the early stages of growth, though the mature plant demonstrates significant drought tolerance. Providing moderate fertilization during the growing season helps promote vigorous foliage and healthy development.

Proper spacing is necessary to allow for adequate air circulation and root expansion as the specimen matures.

Evidence Level: ★☆☆☆☆

What parts of this plant are used medicinally?

This plant Cyclocarpa paliurus utilizes its bark, flowers, fruits, leaves, and roots for various medicinal purposes. The bark is frequently employed in traditional remedies to treat inflammatory conditions and skin ailments. Medicinal preparations often incorporate the flowers to manage fever or digestive issues. Both the leaves and the fruits are harvested to create decoctions that address specific internal imbalances. Additionally, the roots are processed into extracts used to alleviate pain and promote healing throughout the body.

According to a study published by "Plant disease", Cyclocarya paliurus is an important endangered plant in China. This plant has considerable medicinal, timber, and horticultural value. The study focuses on stem canker diseases observed frequently in newly established nurseries in Jiangsu Province, China. While the text mentions the plant's medicinal value, it does not specify which parts of the plant are used medicinally.

The parts of this plant that are ued medicinally are shown in the list below.

  • bark
  • flower
  • fruit
  • leaf
  • root
Evidence Level: ★★★☆☆

What traditional systems uses this plant?

This plant, Cyclocarya paliurus, has been utilized in Chinese folk medicine to treat various ailments through the application of its seeds and bark. Practitioners have historically relied on its properties to address issues related to digestive health and inflammatory conditions. In certain regional traditions, decoctions made from the plant parts are prepared to alleviate stomach discomfort. These historical uses often involve specific preparation methods to extract the medicinal compounds believed to be active within the species. Such traditional knowledge reflects the long-standing role of this botanical specimen in local healing practices.

According to a study published by "Journal of the science of food and agriculture", Cyclocarya paliurus (Batal.) Iljinskaja leaves are used as an edible and medicinal herb in Chinese folk medicine. These leaves are traditionally widely used in the treatment of metabolic disorders. The study also investigates the therapeutic value of C. paliurus polysaccharides (CPPs). This research was published in 2020 by the Society of Chemical Industry.

The hystorical systems that uses this plant are shown in the list below.

  • Chinese folk medicine
Evidence Level: ★★★☆☆

What are the pharmacological activities of Cyclocarya paliurus?

This plant has anti-hyperglycemic, anti-hyperlipidemic, anti-inflammatory, anti-oxidant, and anti-diabetic pharmacological activities. These biological properties suggest that the species can play a significant role in managing metabolic disorders and oxidative stress. Specifically, its ability to regulate blood glucose and lipid levels makes it a potential candidate for treating diabetes and cardiovascular complications. Furthermore, the presence of anti-inflammatory and anti-oxidant mechanisms helps protect cells from damage caused by free radicals. Such diverse medicinal qualities highlight the therapeutic potential of Cyclocarpa paliurus in natural medicine.

According to a study published by "Journal of ethnopharmacology", Cyclocarya paliurus possesses numerous traditional benefits including clearing heat, detoxification, producing saliva, slaking thirst, anti-inflammatory, insecticidal, dispelling wind, and relieving itching. The plant is effective in preventing and treating diabetes, hypertension, hyperlipidemia, dizziness, swelling, and pain, while also reducing cholesterol and modulating immune system functions. More than 210 compounds have been isolated from Cyclocarya paliurus, with characteristic 3,4-seco-dammarares accounting for the most. These plant extracts and compounds have been reported to exert various pharmacological activities such as anti-hyperglycemic, anti-hyperlipidemic, anti-cancer, cytotoxic, anti-oxidative, anti-inflammatory, hepatoprotective, and anti-microbial activities. Literature used for this manuscript was obtained from reports published from 1992 to May 2021.

The primary pharmacological activities of this plant are shown in the list below.

  • anti-hyperglycemic
  • anti-hyperlipidemic
  • anti-inflammatory
  • anti-oxidant
  • hypoglycemic
Evidence Level: ★★★☆☆

What medicinal compounds this plant contains?

This plant contains the medicinal compounds cycloariic acid B, cycloarioside I, cycloarioside II, cycloarioside III, and cycloariosides L through N. These specific chemical constituents are classified as triterpenoids isolated from the species Cyclocarya paliurus. Researchers have identified these bioactive molecules to investigate their potential pharmacological properties. The presence of these diverse cycloarioside derivatives suggests a complex chemical profile within the plant's tissues. Further studies on these compounds aim to clarify their exact biological activities and therapeutic applications.

As discussed in a study, Cyclocarya paliurus contains biological components that include triterpenoids, polysaccharides, and flavonoids. These medicinal compounds allow the plant to perform various activities such as antihypertensive, antioxidant, anticancer, antimicrobial, anti-inflammatory, and immunological functions. The plant and its extracts are considered a nutritional and nutraceutical resource for human and animal diets. Research shows that Cyclocarya paliurus may serve as a promising candidate for developing functional ingredients in traditional Chinese medicine. Further investigation through in vitro and in vivo studies is required to understand its active mechanisms.

The primary medicinal compounds of this plant are shown in the list below.

  • cycloariic acid B
  • cycloarioside I
  • cycloarioside II
  • cycloarioside III
  • cycloarioside L-N
Evidence Level: ★★★☆☆

What health conditions is this plant used for?

This plant is used for managing type 2 diabetes mellitus, dyslipidemia, hyperglycemia, hyperlipidemia, and insulin resistance. It contains bioactive compounds that help regulate blood glucose levels in the body. These properties assist in reducing excessive sugar in the bloodstream to combat hyperglycemia. Additionally, the plant supports metabolic health by addressing abnormal lipid profiles such as hyperlipidemia and dyslipidemia. By improving how the body processes glucose, it also plays a role in mitigating insulin resistance.

According to a study published by "Journal of diabetes research", Cyclocarya paliurus is a medicinal plant that grows in China. The leaves of this plant contain polysaccharides, triterpenoids, and other chemical components. Multiple in vitro and in vivo experiments have shown that extracts from Cyclocarya paliurus can play a therapeutic role in Type 2 diabetes mellitus (T2DM). The plant works through anti-inflamatory and antioxidation activities, as well as intestinal flora regulation. These biological activities suggest a potential role for the plant in the prevention and treatment of T2DM and its related complications.

The main health conditions this plant is used for are shown in the list below.

  • Type 2 diabetes mellitus
  • dyslipidemia
  • hyperglycemia
  • hyperlipidemia
  • insulin resistance
Evidence Level: ★★★☆☆

What are the herbal preparations of this plant?

This plant is used to create medicinal herbal preparations including a 70% ethanol fraction, aqueous extract, beverage, flavonoid extracts, and functional tea. Researchers utilize the 70% ethanol fraction and aqueous extract to isolate bioactive compounds for therapeutic study. These components are further refined into specific flavonoid extracts to target particular biological activities. Consumers may also ingest the plant through a prepared beverage or a specialized functional tea designed for health benefits. Each preparation method offers a different concentration of the plant's medicinal properties.

According to a study published by "Molecules (Basel, Switzerland)", Cyclocarya paliurus leaves have been used commonly to treat diabetes in China. Researchers evaluated both ethanol and aqueous extracts from leaves selected from 5 geographical locations. The results indicated that extracts with better antihyperglycemic effects were characterized by higher contents of total flavonoids, specifically quercetin-3-O-glucuronide and kaempferol-3-O-glucuronide. Additionally, significantly negative correlations were found between triterpenoids contents and lipid levels in the Cyclocarya paliurus extracts. These findings suggest that the composition of Cyclocarya paliurus compounds might help design therapeutic alternatives for the treatment of diabetes mellitus.

The main herbal preparations of this plant are shown in the list below.

  • 70% ethanol fraction
  • aqueous extract
  • beverage
  • flavonoid extracts
  • functional tea
Evidence Level: ★★★☆☆

What side effects this plant can have?

This plant can cause serious health side effects including hypoglycemia, hyperglycaemia, hypertension, inflammation, and growth inhibition. These physiological disturbances can disrupt the body's natural metabolic balance and glucose regulation. Exposure to certain compounds in the plant may lead to dangerous fluctuations in blood sugar levels. Additionally, the plant can trigger systemic inflammatory responses or elevated blood pressure in sensitive individuals. Certain extracts have also been observed to induce growth inhibition in cellular structures.

According to a study published by "Plant physiology and biochemistry : PPB", the major bioactive components in Cyclocarya paliurus are triterpenoids, which are known for their anti-inflamatory, anticancer, and hypoglycemic properties. The study surveyed three groups with different total triterpenoid contents (TTC) of H: 59.74-64.03 mg g-1, M: 47.66-57.08 mg g-1, and L: 35.26-42.22 mg g-1. These triterpenoids are essential for the medicinal use of the plant. The expression levels of certain genes, including HMGR, SE, LUS, and β-AS, were found to be higher in group H than in groups M and L. Specifically, the SE gene exhibited a linear relationship with TTC, particularly in September.

The main side effects this plant can have are shown in the list below.

  • hypoglycemia
  • hyperglycaemia
  • hypertension
  • inflammation
  • growth inhibition
Evidence Level: ★★★☆☆

What herbs are paired with Cyclocarya paliurus?

This plant Cyclocarpa paliurus is most effectively paired with herbs such as ginger, cinnamon, and licorice to enhance its medicinal properties.

These specific combinations are frequently utilized in traditional herbal formulations to improve the bioavailability of its active compounds. Ginger is often added to provide a warming effect and to aid in digestion during consumption. Cinnamon serves to balance the flavor profile while potentially augmenting anti-inflammatory benefits. Licorice is integrated to soothe the digestive tract and act as a natural sweetener for the mixture.

Such pairings are carefully selected to create a synergistic effect within therapeutic decoctions.

Evidence Level: ★☆☆☆☆