saffron crocus
Crocus sativus · Accepted scientific name
Scientific literature: Very Extensive (1465 studies) · ★★★★★
Saffron crocus, scientifically known as Crocus sativus, is a perennial plant celebrated for its precious, crimson stigmas. Harvested manually, these threads provide saffron, the world's most expensive spice. Beyond culinary brilliance, this remarkable plant offers significant medicinal benefits, including antioxidant, antidepressant, and anti-inflammatory properties used in traditional healing.
Names
Common Names
- Saffron Crocus
- autumn crocus
- saffron
Regional and Traditional Names
Spanish:
- azafrán
- azafrán
German:
- Safran
- Safran
- Echter Safran Nom
- Echter Safran
- Saffran-Krokus
French:
- Crocus cultive
- Crocus à safran
- Safran cultivé
Scientific Names
Accepted name
Crocus sativusSynonyms
- Crocus sativus subsp. orsinii
- Safran officinarum
- Geanthus autumnalis
- Crocus sativus var. orsinii
- Crocus setifolius
- Crocus officinalis
- Crocus orsinii
- Crocus sativus var. cashmerianus
- Crocus sativus var. officinalis
- Crocus pendulus
Taxonomical Classification
This plant belongs to the kingdom Plantae and is classified under the phylum Streptophyta and the class Equisetopsida. Within the subclass Magnoliidae, it follows the order Asparagales and is a member of the family Iridaceae. Finally, its taxonomic identity is defined by the genus Crocus.
| Rank | Classification | Source |
|---|---|---|
| Kingdom | Plantae | WCVP |
| Phylum | Streptophyta | WCVP |
| Class | Equisetopsida | WCVP |
| Subclass | Magnoliidae | WCVP |
| Order | Asparagales | WCVP |
| Family | Iridaceae | WCVP |
| Genus | Crocus | WCVP |
Distribution
This plant exhibits a diverse geographical distribution spanning several distinct regions across three continents. In Middle Europe, its presence can be noted within the territories of Czechia and Slovakia. Moving toward the Mediterranean, it is widely established in Southwestern Europe, specifically in Spain. The species also thrives in Southeastern Europe, with significant populations found in both Greece and Italy. Finally, its range extends into Northern Africa, where it is documented in Morocco.
| Region | Area | Source |
|---|---|---|
| Middle Europe | Czechia-Slovakia | WCVP |
| Southwestern Europe | Spain | WCVP |
| Southeastern Europe | Greece | WCVP |
| Southeastern Europe | Italy | WCVP |
| Northern Africa | Morocco | WCVP |
| Western Asia | Iran | WCVP |
| Western Asia | Türkiye | WCVP |
| Indian Subcontinent | Pakistan | WCVP |
| Indian Subcontinent | West Himalaya | WCVP |
Plant Parts
This plant, known scientifically as Crocus sativus, is a perennial herb highly valued for its unique reproductive structures. The most precious part of the plant comes from its purple flowers, which contain three long, crimson-colored stigmas. Each individual flower produces these distinct stigma threads, which are carefully hand-harvested to produce the world's most expensive spice, saffron. Once the dried stigmas are collected and processed, they are used globally for their intense flavor, vibrant coloring properties, and significant medicinal benefits.| Plant Part | Sources | Consensus |
|---|---|---|
| flower | Journal of food biochemistry (and other 3 sources) | ★★☆☆☆ |
| leaf | Current microbiology (and other 1 sources) | ★☆☆☆☆ |
Chemicals
Crocus sativus has 193 reported phytochemicals identified across 4 scientific publications and several other databases. The most consistently reported chemicals include Safranal, Crocetin, Crocin, Picrocrocin, Flavonoids.
| Chemical | Supporting sources | Consensus |
|---|---|---|
| Safranal | 34 supporting sources | ★★★★★ |
| Crocetin | 31 supporting sources | ★★★★★ |
| Crocin | 29 supporting sources | ★★★★★ |
| Picrocrocin | 25 supporting sources | ★★★★★ |
| Flavonoids | 12 supporting sources | ★★★★★ |
| Carotenoids | 9 supporting sources | ★★★★☆ |
| Crocine | 7 supporting sources | ★★★★☆ |
| Saffron | 7 supporting sources | ★★★★☆ |
| Zeaxanthin | 7 supporting sources | ★★★★☆ |
| Anthocyanins | 5 supporting sources | ★★★☆☆ |
Safranal
- Dr. Duke
- Critical reviews in food science and nutrition
- Molecules (Basel, Switzerland)
- Journal of ethnopharmacology
- Plants (Basel, Switzerland)
View 29 additional sources
- Natural product communications
- Jundishapur journal of natural pharmaceutical products
- Phytomedicine : international journal of phytotherapy and phytopharmacology
- Natural product research
- Food chemistry. Molecular sciences
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- Current pharmaceutical design
- Evidence-based complementary and alternative medicine : eCAM
- Journal of proteomics
- Briefings in functional genomics
- Naunyn-Schmiedeberg's archives of pharmacology
- Drug research
- Pharmaceuticals (Basel, Switzerland)
- Physiology and molecular biology of plants : an international journal of functional plant biology
- Genome
- Iranian journal of basic medical sciences
- BMC plant biology
- Avicenna journal of phytomedicine
- Frontiers in pharmacology
- Planta medica
- Nutrients
- Journal of proteome research
- Bioinformation
- Computational and structural biotechnology journal
- Oxidative medicine and cellular longevity
- Phytotherapy research : PTR
- Phytochemistry
- Scientific reports
- European journal of drug metabolism and pharmacokinetics
Crocetin
- Dr. Duke
- Frontiers in pharmacology
- Antioxidants (Basel, Switzerland)
- Plants (Basel, Switzerland)
- BioFactors (Oxford, England)
View 26 additional sources
- Journal of vascular research
- Journal of cellular biochemistry
- Phytomedicine : international journal of phytotherapy and phytopharmacology
- Current neuropharmacology
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- Current pharmaceutical design
- Evidence-based complementary and alternative medicine : eCAM
- Anti-cancer agents in medicinal chemistry
- Naunyn-Schmiedeberg's archives of pharmacology
- Pharmaceuticals (Basel, Switzerland)
- International journal of molecular sciences
- Food & function
- Neural regeneration research
- Journal of ethnopharmacology
- European journal of medicinal chemistry
- Iranian journal of basic medical sciences
- Plant physiology
- Nutrients
- Anticancer research
- Bioinformation
- Oxidative medicine and cellular longevity
- Phytochemistry
- Planta medica
- European journal of drug metabolism and pharmacokinetics
- Journal of microbiology and biotechnology
- Anti-inflammatory & anti-allergy agents in medicinal chemistry
Crocin
- Dr. Duke
- Naunyn-Schmiedeberg's archives of pharmacology
- Plant foods for human nutrition (Dordrecht, Netherlands)
- Journal of ethnopharmacology
- International journal of molecular sciences
View 24 additional sources
- DNA and cell biology
- Current neuropharmacology
- Biochimie
- Scientific reports
- Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences
- Frontiers in nutrition
- Physiology and molecular biology of plants : an international journal of functional plant biology
- Food science & nutrition
- Phytomedicine : international journal of phytotherapy and phytopharmacology
- Toxicology and industrial health
- Neural regeneration research
- Pharmaceutical biology
- Marine drugs
- Metabolic brain disease
- Avicenna journal of phytomedicine
- Molecules (Basel, Switzerland)
- Iranian journal of basic medical sciences
- Behavioural pharmacology
- Planta medica
- Bioinformation
- Computational and structural biotechnology journal
- Phytochemistry
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- BioFactors (Oxford, England)
Picrocrocin
- Dr. Duke
- Critical reviews in food science and nutrition
- Plants (Basel, Switzerland)
- Phytomedicine : international journal of phytotherapy and phytopharmacology
- Food chemistry. Molecular sciences
View 20 additional sources
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- Current pharmaceutical design
- Evidence-based complementary and alternative medicine : eCAM
- Journal of proteomics
- Briefings in functional genomics
- Journal of chromatography. A
- Anti-cancer agents in medicinal chemistry
- Pharmaceuticals (Basel, Switzerland)
- Physiology and molecular biology of plants : an international journal of functional plant biology
- Avicenna journal of phytomedicine
- Molecules (Basel, Switzerland)
- Natural product research
- Planta medica
- Anticancer research
- Bioinformation
- Computational and structural biotechnology journal
- Oxidative medicine and cellular longevity
- Scientific reports
- Phytochemistry
- European journal of drug metabolism and pharmacokinetics
Flavonoids
- Critical reviews in food science and nutrition
- Journal of food biochemistry
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- Current pharmaceutical design
- Molecules (Basel, Switzerland)
View 7 additional sources
- Food science & nutrition
- Plants (Basel, Switzerland)
- Iranian journal of basic medical sciences
- Food chemistry: X
- Journal of the American Nutrition Association
- Pharmaceuticals (Basel, Switzerland)
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Carotenoids
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- Current pharmaceutical design
- Physiology and molecular biology of plants : an international journal of functional plant biology
- Current medicinal chemistry
- Journal of traditional and complementary medicine
View 4 additional sources
- Nutrients
- Acta pharmaceutica Sinica. B
- Food chemistry: X
- Pharmaceuticals (Basel, Switzerland)
Crocine
- Critical reviews in food science and nutrition
- Briefings in functional genomics
- Current microbiology
- Cellular and molecular biology (Noisy-le-Grand, France)
- Anticancer research
View 2 additional sources
- Planta medica
- Journal of microbiology and biotechnology
Saffron
- Current neuropharmacology
- Food science & nutrition
- Asian Pacific journal of cancer prevention : APJCP
- Current drug discovery technologies
- Zeitschrift fur Rheumatologie
View 2 additional sources
- Canadian journal of psychiatry. Revue canadienne de psychiatrie
- Journal of midwifery & women's health
Zeaxanthin
- Dr. Duke
- Plant foods for human nutrition (Dordrecht, Netherlands)
- International journal of molecular sciences
- BMC plant biology
- Plant physiology
View 2 additional sources
- Nutrients
- Acta pharmaceutica Sinica. B
Anthocyanins
- Scientific reports
- Current pharmaceutical design
- Plants (Basel, Switzerland)
- Iranian journal of basic medical sciences
- Food chemistry: X
Activities
Crocus sativus has 518 reported activities identified across 4 scientific publications and several other databases. The most consistently reported activities include Antioxidant, Neuroprotective, Anticancer, Antidepressant, Cytotoxic.
Most Reported Activities
| Activity | Sources | Consensus |
|---|---|---|
| Antioxidant | Dr. Duke (and other 39 sources) | ★★★★★ |
| Neuroprotective | Dr. Duke (and other 16 sources) | ★★★★★ |
| Anticancer | Dr. Duke (and other 12 sources) | ★★★★★ |
| Antidepressant | Dr. Duke (and other 11 sources) | ★★★★★ |
| Cytotoxic | Dr. Duke (and other 7 sources) | ★★★★☆ |
| Antimicrobial | TheScientificWorldJournal (and other 6 sources) | ★★★☆☆ |
| Antitumor | Dr. Duke (and other 5 sources) | ★★★☆☆ |
| Anxiolytic | Dr. Duke (and other 5 sources) | ★★★☆☆ |
| Antibacterial | Dr. Duke (and other 4 sources) | ★★☆☆☆ |
| Anticonvulsant | Dr. Duke (and other 4 sources) | ★★☆☆☆ |
Medicinal Uses
Crocus sativus has 176 reported medicinal uses identified across 4 scientific publications and several other databases. The most consistently reported uses include depression, Alzheimer's disease, anxiety, cancer, neurodegenerative diseases.
Most Reported Uses
| Use | Sources | Consensus |
|---|---|---|
| depression | Phytomedicine : international journal of phytotherapy and phytopharmacology (and other 18 sources) | ★★★★★ |
| Alzheimer's disease | Archives of Iranian medicine (and other 11 sources) | ★★★★★ |
| anxiety | Neuropsychiatric disease and treatment (and other 9 sources) | ★★★★☆ |
| cancer | Wiener medizinische Wochenschrift (1946) (and other 9 sources) | ★★★★☆ |
| neurodegenerative diseases | Archives of Iranian medicine (and other 8 sources) | ★★★★☆ |
| oxidative stress | Nephrology (Carlton, Vic.) (and other 8 sources) | ★★★★☆ |
| inflammation | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (and other 7 sources) | ★★★★☆ |
| antioxidant | Natural product research (and other 6 sources) | ★★★☆☆ |
| hypertension | Antioxidants (Basel, Switzerland) (and other 6 sources) | ★★★☆☆ |
| neurodegenerative disorders | Current pharmaceutical design (and other 5 sources) | ★★★☆☆ |
Preparations
| Preparations | Sources | Consensus |
|---|---|---|
| dried stigmas | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (and other 3 sources) | ★★☆☆☆ |
| aqueous-ethanolic extracts | Die Pharmazie (and other 2 sources) | ★☆☆☆☆ |
| crocin | Metabolic brain disease (and other 2 sources) | ★☆☆☆☆ |
| extract | Infectious disorders drug targets (and other 2 sources) | ★☆☆☆☆ |
| saffron | Food science & nutrition (and other 2 sources) | ★☆☆☆☆ |
| CE | Letters in applied microbiology (and other 1 sources) | ★☆☆☆☆ |
| Crocin | Biochimie (and other 1 sources) | ★☆☆☆☆ |
| Crocus sativus stigmas | Journal de pharmacie de Belgique (and other 1 sources) | ★☆☆☆☆ |
| Crude extracts | Pakistan journal of pharmaceutical sciences (and other 1 sources) | ★☆☆☆☆ |
| Gurgem-7 | Ecotoxicology and environmental safety (and other 1 sources) | ★☆☆☆☆ |