saffron crocus

Crocus sativus · Accepted scientific name

Scientific literature: Very Extensive (1465 studies) · ★★★★★

Saffron crocus, scientifically known as Crocus sativus, is a perennial plant celebrated for its precious, crimson stigmas. Harvested manually, these threads provide saffron, the world's most expensive spice. Beyond culinary brilliance, this remarkable plant offers significant medicinal benefits, including antioxidant, antidepressant, and anti-inflammatory properties used in traditional healing.

Family
Iridaceae
Native range
Europe
Parts used
Flower · Leaf
Common names
Saffron Crocus · Autumn Crocus · 1 more
Scientific synonyms
Crocus Sativus Subsp. Orsinii · Safran Officinarum · 8 more

Names

Common Names

Regional and Traditional Names

Spanish:

  • azafrán
  • azafrán

German:

  • Safran
  • Safran
  • Echter Safran Nom
  • Echter Safran
  • Saffran-Krokus

French:

  • Crocus cultive
  • Crocus à safran
  • Safran cultivé

Scientific Names

Accepted name

Crocus sativus

Synonyms

Taxonomical Classification

This plant belongs to the kingdom Plantae and is classified under the phylum Streptophyta and the class Equisetopsida. Within the subclass Magnoliidae, it follows the order Asparagales and is a member of the family Iridaceae. Finally, its taxonomic identity is defined by the genus Crocus.

Rank Classification Source
Kingdom Plantae WCVP
Phylum Streptophyta WCVP
Class Equisetopsida WCVP
Subclass Magnoliidae WCVP
Order Asparagales WCVP
Family Iridaceae WCVP
Genus Crocus WCVP

Distribution

This plant exhibits a diverse geographical distribution spanning several distinct regions across three continents. In Middle Europe, its presence can be noted within the territories of Czechia and Slovakia. Moving toward the Mediterranean, it is widely established in Southwestern Europe, specifically in Spain. The species also thrives in Southeastern Europe, with significant populations found in both Greece and Italy. Finally, its range extends into Northern Africa, where it is documented in Morocco.

Region Area Source
Middle Europe Czechia-Slovakia WCVP
Southwestern Europe Spain WCVP
Southeastern Europe Greece WCVP
Southeastern Europe Italy WCVP
Northern Africa Morocco WCVP
Western Asia Iran WCVP
Western Asia Türkiye WCVP
Indian Subcontinent Pakistan WCVP
Indian Subcontinent West Himalaya WCVP

Plant Parts

This plant, known scientifically as Crocus sativus, is a perennial herb highly valued for its unique reproductive structures. The most precious part of the plant comes from its purple flowers, which contain three long, crimson-colored stigmas. Each individual flower produces these distinct stigma threads, which are carefully hand-harvested to produce the world's most expensive spice, saffron. Once the dried stigmas are collected and processed, they are used globally for their intense flavor, vibrant coloring properties, and significant medicinal benefits.
Plant Part Sources Consensus
flower Journal of food biochemistry (and other 3 sources) ★★☆☆☆
leaf Current microbiology (and other 1 sources) ★☆☆☆☆

Chemicals

Crocus sativus has 193 reported phytochemicals identified across 4 scientific publications and several other databases. The most consistently reported chemicals include Safranal, Crocetin, Crocin, Picrocrocin, Flavonoids.

Chemicals reported in Crocus sativus
Chemical Supporting sources Consensus
Safranal 34 supporting sources ★★★★★
Crocetin 31 supporting sources ★★★★★
Crocin 29 supporting sources ★★★★★
Picrocrocin 25 supporting sources ★★★★★
Flavonoids 12 supporting sources ★★★★★
Carotenoids 9 supporting sources ★★★★☆
Crocine 7 supporting sources ★★★★☆
Saffron 7 supporting sources ★★★★☆
Zeaxanthin 7 supporting sources ★★★★☆
Anthocyanins 5 supporting sources ★★★☆☆

Safranal

  1. Dr. Duke
  2. Critical reviews in food science and nutrition
  3. Molecules (Basel, Switzerland)
  4. Journal of ethnopharmacology
  5. Plants (Basel, Switzerland)
View 29 additional sources
  1. Natural product communications
  2. Jundishapur journal of natural pharmaceutical products
  3. Phytomedicine : international journal of phytotherapy and phytopharmacology
  4. Natural product research
  5. Food chemistry. Molecular sciences
  6. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
  7. Current pharmaceutical design
  8. Evidence-based complementary and alternative medicine : eCAM
  9. Journal of proteomics
  10. Briefings in functional genomics
  11. Naunyn-Schmiedeberg's archives of pharmacology
  12. Drug research
  13. Pharmaceuticals (Basel, Switzerland)
  14. Physiology and molecular biology of plants : an international journal of functional plant biology
  15. Genome
  16. Iranian journal of basic medical sciences
  17. BMC plant biology
  18. Avicenna journal of phytomedicine
  19. Frontiers in pharmacology
  20. Planta medica
  21. Nutrients
  22. Journal of proteome research
  23. Bioinformation
  24. Computational and structural biotechnology journal
  25. Oxidative medicine and cellular longevity
  26. Phytotherapy research : PTR
  27. Phytochemistry
  28. Scientific reports
  29. European journal of drug metabolism and pharmacokinetics

Crocetin

  1. Dr. Duke
  2. Frontiers in pharmacology
  3. Antioxidants (Basel, Switzerland)
  4. Plants (Basel, Switzerland)
  5. BioFactors (Oxford, England)
View 26 additional sources
  1. Journal of vascular research
  2. Journal of cellular biochemistry
  3. Phytomedicine : international journal of phytotherapy and phytopharmacology
  4. Current neuropharmacology
  5. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
  6. Current pharmaceutical design
  7. Evidence-based complementary and alternative medicine : eCAM
  8. Anti-cancer agents in medicinal chemistry
  9. Naunyn-Schmiedeberg's archives of pharmacology
  10. Pharmaceuticals (Basel, Switzerland)
  11. International journal of molecular sciences
  12. Food & function
  13. Neural regeneration research
  14. Journal of ethnopharmacology
  15. European journal of medicinal chemistry
  16. Iranian journal of basic medical sciences
  17. Plant physiology
  18. Nutrients
  19. Anticancer research
  20. Bioinformation
  21. Oxidative medicine and cellular longevity
  22. Phytochemistry
  23. Planta medica
  24. European journal of drug metabolism and pharmacokinetics
  25. Journal of microbiology and biotechnology
  26. Anti-inflammatory & anti-allergy agents in medicinal chemistry

Crocin

  1. Dr. Duke
  2. Naunyn-Schmiedeberg's archives of pharmacology
  3. Plant foods for human nutrition (Dordrecht, Netherlands)
  4. Journal of ethnopharmacology
  5. International journal of molecular sciences
View 24 additional sources
  1. DNA and cell biology
  2. Current neuropharmacology
  3. Biochimie
  4. Scientific reports
  5. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences
  6. Frontiers in nutrition
  7. Physiology and molecular biology of plants : an international journal of functional plant biology
  8. Food science & nutrition
  9. Phytomedicine : international journal of phytotherapy and phytopharmacology
  10. Toxicology and industrial health
  11. Neural regeneration research
  12. Pharmaceutical biology
  13. Marine drugs
  14. Metabolic brain disease
  15. Avicenna journal of phytomedicine
  16. Molecules (Basel, Switzerland)
  17. Iranian journal of basic medical sciences
  18. Behavioural pharmacology
  19. Planta medica
  20. Bioinformation
  21. Computational and structural biotechnology journal
  22. Phytochemistry
  23. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  24. BioFactors (Oxford, England)

Picrocrocin

  1. Dr. Duke
  2. Critical reviews in food science and nutrition
  3. Plants (Basel, Switzerland)
  4. Phytomedicine : international journal of phytotherapy and phytopharmacology
  5. Food chemistry. Molecular sciences
View 20 additional sources
  1. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
  2. Current pharmaceutical design
  3. Evidence-based complementary and alternative medicine : eCAM
  4. Journal of proteomics
  5. Briefings in functional genomics
  6. Journal of chromatography. A
  7. Anti-cancer agents in medicinal chemistry
  8. Pharmaceuticals (Basel, Switzerland)
  9. Physiology and molecular biology of plants : an international journal of functional plant biology
  10. Avicenna journal of phytomedicine
  11. Molecules (Basel, Switzerland)
  12. Natural product research
  13. Planta medica
  14. Anticancer research
  15. Bioinformation
  16. Computational and structural biotechnology journal
  17. Oxidative medicine and cellular longevity
  18. Scientific reports
  19. Phytochemistry
  20. European journal of drug metabolism and pharmacokinetics

Flavonoids

  1. Critical reviews in food science and nutrition
  2. Journal of food biochemistry
  3. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
  4. Current pharmaceutical design
  5. Molecules (Basel, Switzerland)
View 7 additional sources
  1. Food science & nutrition
  2. Plants (Basel, Switzerland)
  3. Iranian journal of basic medical sciences
  4. Food chemistry: X
  5. Journal of the American Nutrition Association
  6. Pharmaceuticals (Basel, Switzerland)
  7. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

Carotenoids

  1. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
  2. Current pharmaceutical design
  3. Physiology and molecular biology of plants : an international journal of functional plant biology
  4. Current medicinal chemistry
  5. Journal of traditional and complementary medicine
View 4 additional sources
  1. Nutrients
  2. Acta pharmaceutica Sinica. B
  3. Food chemistry: X
  4. Pharmaceuticals (Basel, Switzerland)

Crocine

  1. Critical reviews in food science and nutrition
  2. Briefings in functional genomics
  3. Current microbiology
  4. Cellular and molecular biology (Noisy-le-Grand, France)
  5. Anticancer research
View 2 additional sources
  1. Planta medica
  2. Journal of microbiology and biotechnology

Saffron

  1. Current neuropharmacology
  2. Food science & nutrition
  3. Asian Pacific journal of cancer prevention : APJCP
  4. Current drug discovery technologies
  5. Zeitschrift fur Rheumatologie
View 2 additional sources
  1. Canadian journal of psychiatry. Revue canadienne de psychiatrie
  2. Journal of midwifery & women's health

Zeaxanthin

  1. Dr. Duke
  2. Plant foods for human nutrition (Dordrecht, Netherlands)
  3. International journal of molecular sciences
  4. BMC plant biology
  5. Plant physiology
View 2 additional sources
  1. Nutrients
  2. Acta pharmaceutica Sinica. B

Anthocyanins

  1. Scientific reports
  2. Current pharmaceutical design
  3. Plants (Basel, Switzerland)
  4. Iranian journal of basic medical sciences
  5. Food chemistry: X

Activities

Crocus sativus has 518 reported activities identified across 4 scientific publications and several other databases. The most consistently reported activities include Antioxidant, Neuroprotective, Anticancer, Antidepressant, Cytotoxic.

Most Reported Activities

Activity Sources Consensus
Antioxidant Dr. Duke (and other 39 sources) ★★★★★
Neuroprotective Dr. Duke (and other 16 sources) ★★★★★
Anticancer Dr. Duke (and other 12 sources) ★★★★★
Antidepressant Dr. Duke (and other 11 sources) ★★★★★
Cytotoxic Dr. Duke (and other 7 sources) ★★★★☆
Antimicrobial TheScientificWorldJournal (and other 6 sources) ★★★☆☆
Antitumor Dr. Duke (and other 5 sources) ★★★☆☆
Anxiolytic Dr. Duke (and other 5 sources) ★★★☆☆
Antibacterial Dr. Duke (and other 4 sources) ★★☆☆☆
Anticonvulsant Dr. Duke (and other 4 sources) ★★☆☆☆

Medicinal Uses

Crocus sativus has 176 reported medicinal uses identified across 4 scientific publications and several other databases. The most consistently reported uses include depression, Alzheimer's disease, anxiety, cancer, neurodegenerative diseases.

Most Reported Uses

Use Sources Consensus
depression Phytomedicine : international journal of phytotherapy and phytopharmacology (and other 18 sources) ★★★★★
Alzheimer's disease Archives of Iranian medicine (and other 11 sources) ★★★★★
anxiety Neuropsychiatric disease and treatment (and other 9 sources) ★★★★☆
cancer Wiener medizinische Wochenschrift (1946) (and other 9 sources) ★★★★☆
neurodegenerative diseases Archives of Iranian medicine (and other 8 sources) ★★★★☆
oxidative stress Nephrology (Carlton, Vic.) (and other 8 sources) ★★★★☆
inflammation Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (and other 7 sources) ★★★★☆
antioxidant Natural product research (and other 6 sources) ★★★☆☆
hypertension Antioxidants (Basel, Switzerland) (and other 6 sources) ★★★☆☆
neurodegenerative disorders Current pharmaceutical design (and other 5 sources) ★★★☆☆

Preparations

Preparations Sources Consensus
dried stigmas Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (and other 3 sources) ★★☆☆☆
aqueous-ethanolic extracts Die Pharmazie (and other 2 sources) ★☆☆☆☆
crocin Metabolic brain disease (and other 2 sources) ★☆☆☆☆
extract Infectious disorders drug targets (and other 2 sources) ★☆☆☆☆
saffron Food science & nutrition (and other 2 sources) ★☆☆☆☆
CE Letters in applied microbiology (and other 1 sources) ★☆☆☆☆
Crocin Biochimie (and other 1 sources) ★☆☆☆☆
Crocus sativus stigmas Journal de pharmacie de Belgique (and other 1 sources) ★☆☆☆☆
Crude extracts Pakistan journal of pharmaceutical sciences (and other 1 sources) ★☆☆☆☆
Gurgem-7 Ecotoxicology and environmental safety (and other 1 sources) ★☆☆☆☆