Cratoxylum arborescens
Cratoxylum arborescens · Accepted scientific name
Scientific literature: Very Sparse (1 studies) · ★☆☆☆☆
Cratoxylum arborescens is a botanical species that has garnered significant scientific interest due to its potential therapeutic properties. Recent investigations have focused on its biological activities, particularly its demonstrated antitumor potential. Researchers have specifically explored the efficacy of this plant in addressing the challenges posed by cervical cancer. Studies involving HeLa cells have provided critical insights into how its extracts interact with malignant cell lines. These findings highlight the importance of further examining this plant as a source for developing novel cancer treatments.
- Synonyms
- Hypericum Arborescens · Vismia Arborescens
- Common names
- Not available
- Family
- Hypericaceae
- Distribution
- Not available
- Plant Parts
- Not available
Classification
Common Names
Cratoxylum arborescens is a botanical species recognized by a variety of distinct local names across different regions. Depending on the specific area, it is commonly referred to as Geronggang by many inhabitants. Some communities also identify the plant as Kayu Temau, highlighting its regional importance. Furthermore, the names Lede and Serungan are frequently used to describe this particular tree in various dialects. This diversity in nomenclature underscores the widespread presence and cultural significance of the species.
Sources: Catalogue of Life (COL)
Synonyms
Cratoxylum arborescens is a botanical species that has been subject to various taxonomic reclassifications over time. Due to historical shifts in classification, the plant is also known by its synonym Hypericum arborescens. Additionally, researchers have previously identified this same species under the name Vismia arborescens. These overlapping names highlight the evolving nature of plant nomenclature and scientific study. Understanding these relationships is essential for maintaining accuracy in botanical records and ecological research.
Sources: The World Checklist of Vascular Plants (WCVP)
Taxonomy
Cratoxylum arborescens is a distinguished botanical specimen belonging to the kingdom Plantae. Within this vast realm, it is specifically classified under the class Equisetopsida. The plant is further organized into the order Malpighiales, reflecting its evolutionary lineage. It finds its place within the genus Cratoxylum, a group defined by unique morphological traits. Finally, this species is a member of the family Hypericaceae, completing its scientific identity.
| Rank | Classification |
|---|---|
| Kingdom | Plantae |
| Phylum | Streptophyta |
| Class | Equisetopsida |
| Subclass | Magnoliidae |
| Order | Malpighiales |
| Family | Hypericaceae |
| Genus | Cratoxylum |
Sources: The World Checklist of Vascular Plants (WCVP)
Distribution
Geographic Regions
Cratoxylum arborescens is a tropical species widely distributed across various regions of Asia. Its presence is well-documented throughout Indo-China, spanning specifically into Myanmar and Thailand. The plant also extends its reach into the Malesia region, making it a common sight in Borneo and Jawa. Furthermore, it can be found growing within the lush landscapes of Malaya. This broad geographical range highlights its significant ecological footprint within tropical ecosystems.
Sources: The World Checklist of Vascular Plants (WCVP)
Identification
Morphology
Cratoxylum arborescens is a magnificent tree characterized by its sturdy, self-supporting growth form. This impressive species can reach significant heights in the wild, typically scaling up to 42 meters. However, under optimal environmental conditions, it has been known to achieve a maximum height of 45 meters. Such towering stature allows it to stand prominently within its natural forest canopy.
Sources: Global Inventory of Floras and Traits (GIFT)
Biological Activities
Cratoxylum arborescens has demonstrated significant potential in the field of oncology through its demonstrated antitumor activity. Specifically, research focusing on the plant-derived compound α-mangostin has revealed a strong anti-proliferative effect against human cervical cancer cells. In vitro studies indicate that this compound inhibits cell viability in a concentration- and time-dependent manner by triggering mitochondrial-dependent apoptosis. This process is driven by mechanisms such as G2/M phase cell cycle arrest and an increase in reactive oxygen species production. Consequently, α-mangostin serves as a promising candidate for further preclinical and in vivo testing in the fight against cervical cancer.
Compounds
Conditions
Cratoxylum arborescens contains the plant-derived compound α-mangostin, which demonstrates a significant anti-proliferative effect on HeLa cells. Research indicates that this compound effectively treats human cervical cancer cells (HeLa) by inhibiting their viability in a concentration- and time-dependent manner. The study shows that α-mangostin treats cervical cancer in vitro by inducing apoptosis through a mitochondrial-dependent pathway. Specifically, the treatment triggers G2/M phase cell cycle arrest and increases ROS production within the cancer cells. Ultimately, the remarkable antitumor effects observed suggest that Cratoxylum arborescens is a potent agent against cervical cancer.