Chinese goldthread
Coptis chinensis · Accepted scientific name
Scientific literature: Very Extensive (682 studies) · ★★★★★
Chinese goldthread, scientifically known as Coptis chinensis, is a perennial herb revered in traditional Chinese medicine. Renowned for its high berberine content, this plant offers potent anti-inflammatory and antimicrobial properties. It is widely utilized to treat gastrointestinal issues, infections, and metabolic disorders, serving as a cornerstone in herbal pharmacology.
- Family
- Ranunculaceae
- Native range
- Asia-Temperate
- Parts used
- Rhizome · Root
- Common names
- Chinese Goldthread
- Scientific synonyms
- Coptis Teeta Var. Chinensis
Names
Common Names
- Chinese goldthread
Scientific Names
Accepted name
Coptis chinensisSynonyms
- Coptis teeta var. chinensis
Taxonomical Classification
This plant belongs to the kingdom Plantae and is classified under the phylum Streptophyta and the class Equisetopsida. Within the subclass Magnoliidae, it is organized under the order Ranunculales and the family Ranunculaceae. Finally, its specific taxonomic identity is established within the genus Coptis.
| Rank | Classification | Source |
|---|---|---|
| Kingdom | Plantae | WCVP |
| Phylum | Streptophyta | WCVP |
| Class | Equisetopsida | WCVP |
| Subclass | Magnoliidae | WCVP |
| Order | Ranunculales | WCVP |
| Family | Ranunculaceae | WCVP |
| Genus | Coptis | WCVP |
Distribution
This plant is primarily found across various regions of China. Its distribution includes extensive areas within China South-Central and China North-Central. Additionally, it can be located throughout the China Southeast region. Beyond the borders of China, its presence extends into the Indo-China peninsula. Specifically, it is documented to grow within the country of Vietnam.
| Region | Area | Source |
|---|---|---|
| China | China South-Central | WCVP |
| China | China North-Central | WCVP |
| China | China Southeast | WCVP |
| Indo-China | Vietnam | WCVP |
Plant Parts
This plant, known scientifically as Coptis chinensis, is a perennial herb where the most medicinally significant parts are the underground structures. The medicinal value is primarily concentrated in the rhizome, specifically the thick, yellowish-colored rhizomes that are harvested and dried for use in traditional remedies. While the root system provides structural support, it is the tuberous nature of the rhizome that contains the highest concentration of alkaloids. Above the ground, the plant features distinct green leaves, which are typically divided into multiple leaflets; each individual leaf is characterized by its shape and arrangement, though they are less commonly used for medicinal purposes than the underground parts.| Plant Part | Sources | Consensus |
|---|---|---|
| rhizome | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials (and other 8 sources) | ★★★★☆ |
| root | Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae (and other 8 sources) | ★★★★☆ |
| leaf | Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae (and other 3 sources) | ★★☆☆☆ |
| stem | Mikrochimica acta (and other 1 sources) | ★☆☆☆☆ |
Chemicals
Coptis chinensis has 68 reported phytochemicals identified across 20 scientific publications and several other databases. The most consistently reported chemicals include berberine, Coptisine, Palmatine, Epiberberine, Jatrorrhizine.
| Chemical | Supporting sources | Consensus |
|---|---|---|
| berberine | 33 supporting sources | ★★★★★ |
| Coptisine | 23 supporting sources | ★★★★★ |
| Palmatine | 21 supporting sources | ★★★★★ |
| Epiberberine | 14 supporting sources | ★★★★★ |
| Jatrorrhizine | 11 supporting sources | ★★★★★ |
| Columbamine | 7 supporting sources | ★★★★☆ |
| Berberine hydrochloride | 4 supporting sources | ★★☆☆☆ |
| Jatrorrhizin | 3 supporting sources | ★★☆☆☆ |
| Magnoflorine | 3 supporting sources | ★★☆☆☆ |
| Palmatine chloride | 3 supporting sources | ★★☆☆☆ |
berberine
- Dr. Duke
- Plant physiology and biochemistry : PPB
- Endocrinology
- European journal of drug metabolism and pharmacokinetics
- Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
View 28 additional sources
- Oncology reports
- Phytotherapy research : PTR
- Evidence-based complementary and alternative medicine : eCAM
- Journal of ethnopharmacology
- Frontiers in pharmacology
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- Journal of natural medicines
- PeerJ
- Frontiers in microbiology
- Molecules (Basel, Switzerland)
- Pathology, research and practice
- Chemico-biological interactions
- Genes
- Alternative medicine review : a journal of clinical therapeutic
- Food & function
- Molecular biology reports
- American journal of translational research
- Journal of microbiology and biotechnology
- Molecular medicine reports
- Phytomedicine : international journal of phytotherapy and phytopharmacology
- Journal of microorganism control
- Dose-response : a publication of International Hormesis Society
- Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
- Anti-cancer agents in medicinal chemistry
- Nature communications
- Fitoterapia
- International immunopharmacology
- Guang pu xue yu guang pu fen xi = Guang pu
Coptisine
- Dr. Duke
- Journal of chromatographic science
- Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
- Drug testing and analysis
- European journal of pharmacology
View 18 additional sources
- Journal of ethnopharmacology
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- Journal of natural medicines
- PeerJ
- Frontiers in plant science
- Pathology, research and practice
- Molecules (Basel, Switzerland)
- Planta medica
- Microbiology spectrum
- European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
- Journal of pharmaceutical and biomedical analysis
- Pharmaceutical biology
- Journal of microorganism control
- Dose-response : a publication of International Hormesis Society
- Frontiers in pharmacology
- Chinese journal of natural medicines
- International journal of molecular sciences
- Ecotoxicology and environmental safety
Palmatine
- Dr. Duke
- European journal of drug metabolism and pharmacokinetics
- Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
- Archives of virology
- Drug testing and analysis
View 16 additional sources
- Yao xue xue bao = Acta pharmaceutica Sinica
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- Journal of chromatographic science
- Frontiers in plant science
- Pathology, research and practice
- Planta medica
- European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
- Pharmaceutical biology
- Molecules (Basel, Switzerland)
- Journal of microorganism control
- Dose-response : a publication of International Hormesis Society
- Frontiers in pharmacology
- Chinese journal of natural medicines
- International journal of molecular sciences
- Ecotoxicology and environmental safety
- Toxicology in vitro : an international journal published in association with BIBRA
Epiberberine
- Drug testing and analysis
- Journal of pharmaceutical and biomedical analysis
- Journal of chromatographic science
- PeerJ
- Frontiers in plant science
View 9 additional sources
- Planta medica
- European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
- Pharmaceutical biology
- Journal of microorganism control
- Frontiers in pharmacology
- Chinese journal of natural medicines
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- Ecotoxicology and environmental safety
- Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
Jatrorrhizine
- Journal of pharmaceutical and biomedical analysis
- Drug testing and analysis
- Yao xue xue bao = Acta pharmaceutica Sinica
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- The Journal of pharmacy and pharmacology
View 6 additional sources
- Journal of microorganism control
- Frontiers in plant science
- Frontiers in pharmacology
- Chinese journal of natural medicines
- International journal of molecular sciences
- Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
Columbamine
- Dr. Duke
- Journal of chromatographic science
- Drug testing and analysis
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- Planta medica
View 2 additional sources
- Microbiology spectrum
- Pharmaceutical biology
Berberine hydrochloride
- Journal of chromatographic science
- Scientific reports
- Nihon yakurigaku zasshi. Folia pharmacologica Japonica
- Biomolecules
Jatrorrhizin
- PeerJ
- Frontiers in plant science
- Luminescence : the journal of biological and chemical luminescence
Magnoflorine
- Dr. Duke
- Drug testing and analysis
- Frontiers in pharmacology
Palmatine chloride
- Journal of chromatographic science
- Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
- Microbiology spectrum
Activities
Coptis chinensis has 307 reported activities identified across 20 scientific publications and several other databases. The most consistently reported activities include Antibacterial, Antioxidant, Anticancer, Hypoglycemic, Hypolipidemic.
Most Reported Activities
| Activity | Sources | Consensus |
|---|---|---|
| Antibacterial | Dr. Duke (and other 5 sources) | ★★★☆☆ |
| Antioxidant | Dr. Duke (and other 4 sources) | ★★☆☆☆ |
| Anticancer | Dr. Duke (and other 2 sources) | ★☆☆☆☆ |
| Hypoglycemic | Dr. Duke (and other 2 sources) | ★☆☆☆☆ |
| Hypolipidemic | Dr. Duke (and other 2 sources) | ★☆☆☆☆ |
| (+)-Inotropic | Dr. Duke (and other 1 sources) | ★☆☆☆☆ |
| ACE-Inhibitor | Dr. Duke (and other 1 sources) | ★☆☆☆☆ |
| Abortifacient | Dr. Duke (and other 1 sources) | ★☆☆☆☆ |
| Adrenocorticotrophic | Dr. Duke (and other 1 sources) | ★☆☆☆☆ |
| Adrenolytic | Dr. Duke (and other 1 sources) | ★☆☆☆☆ |
Medicinal Uses
Coptis chinensis has 64 reported medicinal uses identified across 20 scientific publications and several other databases. The most consistently reported uses include Alzheimer's disease, obesity, breast cancer, diabetes mellitus, gastritis.
Most Reported Uses
| Use | Sources | Consensus |
|---|---|---|
| Alzheimer's disease | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (and other 4 sources) | ★★☆☆☆ |
| obesity | American journal of translational research (and other 4 sources) | ★★☆☆☆ |
| breast cancer | Carcinogenesis (and other 3 sources) | ★★☆☆☆ |
| diabetes mellitus | Chinese journal of integrative medicine (and other 3 sources) | ★★☆☆☆ |
| gastritis | Journal of ethnopharmacology (and other 3 sources) | ★★☆☆☆ |
| cancer | Carcinogenesis (and other 2 sources) | ★☆☆☆☆ |
| gastric ulcer | Journal of ethnopharmacology (and other 2 sources) | ★☆☆☆☆ |
| gastric ulcers | Journal of natural medicines (and other 2 sources) | ★☆☆☆☆ |
| hyperglycemia | Frontiers in pharmacology (and other 2 sources) | ★☆☆☆☆ |
| hypertension | Chemico-biological interactions (and other 2 sources) | ★☆☆☆☆ |
Preparations
| Preparations | Sources | Consensus |
|---|---|---|
| Berberine (BBR) | Endocrinology (and other 4 sources) | ★★☆☆☆ |
| aqueous extracts | Journal of pharmaceutical and biomedical analysis (and other 4 sources) | ★★☆☆☆ |
| Berberine hydrochloride | Scientific reports (and other 2 sources) | ★☆☆☆☆ |
| aqueous extract | Molecules (Basel, Switzerland) (and other 2 sources) | ★☆☆☆☆ |
| CEXs | Archives of pharmacal research (and other 1 sources) | ★☆☆☆☆ |
| Coptis chinensis decoction | Mikrochimica acta (and other 1 sources) | ★☆☆☆☆ |
| Coptis chinensis extracts | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (and other 1 sources) | ★☆☆☆☆ |
| Extracts | Life sciences (and other 1 sources) | ★☆☆☆☆ |
| Fractionated Coptis chinensis Extract | Journal of microbiology and biotechnology (and other 1 sources) | ★☆☆☆☆ |
| HL extract | Journal of ethnopharmacology (and other 1 sources) | ★☆☆☆☆ |