Chinese goldthread

Coptis chinensis · Accepted scientific name

Scientific literature: Very Extensive (682 studies) · ★★★★★

Chinese goldthread, scientifically known as Coptis chinensis, is a perennial herb revered in traditional Chinese medicine. Renowned for its high berberine content, this plant offers potent anti-inflammatory and antimicrobial properties. It is widely utilized to treat gastrointestinal issues, infections, and metabolic disorders, serving as a cornerstone in herbal pharmacology.

Family
Ranunculaceae
Native range
Asia-Temperate
Parts used
Rhizome · Root
Common names
Chinese Goldthread
Scientific synonyms
Coptis Teeta Var. Chinensis

Names

Common Names

Scientific Names

Accepted name

Coptis chinensis

Synonyms

Taxonomical Classification

This plant belongs to the kingdom Plantae and is classified under the phylum Streptophyta and the class Equisetopsida. Within the subclass Magnoliidae, it is organized under the order Ranunculales and the family Ranunculaceae. Finally, its specific taxonomic identity is established within the genus Coptis.

Rank Classification Source
Kingdom Plantae WCVP
Phylum Streptophyta WCVP
Class Equisetopsida WCVP
Subclass Magnoliidae WCVP
Order Ranunculales WCVP
Family Ranunculaceae WCVP
Genus Coptis WCVP

Distribution

This plant is primarily found across various regions of China. Its distribution includes extensive areas within China South-Central and China North-Central. Additionally, it can be located throughout the China Southeast region. Beyond the borders of China, its presence extends into the Indo-China peninsula. Specifically, it is documented to grow within the country of Vietnam.

Region Area Source
China China South-Central WCVP
China China North-Central WCVP
China China Southeast WCVP
Indo-China Vietnam WCVP

Plant Parts

This plant, known scientifically as Coptis chinensis, is a perennial herb where the most medicinally significant parts are the underground structures. The medicinal value is primarily concentrated in the rhizome, specifically the thick, yellowish-colored rhizomes that are harvested and dried for use in traditional remedies. While the root system provides structural support, it is the tuberous nature of the rhizome that contains the highest concentration of alkaloids. Above the ground, the plant features distinct green leaves, which are typically divided into multiple leaflets; each individual leaf is characterized by its shape and arrangement, though they are less commonly used for medicinal purposes than the underground parts.
Plant Part Sources Consensus
rhizome Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials (and other 8 sources) ★★★★☆
root Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae (and other 8 sources) ★★★★☆
leaf Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae (and other 3 sources) ★★☆☆☆
stem Mikrochimica acta (and other 1 sources) ★☆☆☆☆

Chemicals

Coptis chinensis has 68 reported phytochemicals identified across 20 scientific publications and several other databases. The most consistently reported chemicals include berberine, Coptisine, Palmatine, Epiberberine, Jatrorrhizine.

Chemicals reported in Coptis chinensis
Chemical Supporting sources Consensus
berberine 33 supporting sources ★★★★★
Coptisine 23 supporting sources ★★★★★
Palmatine 21 supporting sources ★★★★★
Epiberberine 14 supporting sources ★★★★★
Jatrorrhizine 11 supporting sources ★★★★★
Columbamine 7 supporting sources ★★★★☆
Berberine hydrochloride 4 supporting sources ★★☆☆☆
Jatrorrhizin 3 supporting sources ★★☆☆☆
Magnoflorine 3 supporting sources ★★☆☆☆
Palmatine chloride 3 supporting sources ★★☆☆☆

berberine

  1. Dr. Duke
  2. Plant physiology and biochemistry : PPB
  3. Endocrinology
  4. European journal of drug metabolism and pharmacokinetics
  5. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
View 28 additional sources
  1. Oncology reports
  2. Phytotherapy research : PTR
  3. Evidence-based complementary and alternative medicine : eCAM
  4. Journal of ethnopharmacology
  5. Frontiers in pharmacology
  6. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  7. Journal of natural medicines
  8. PeerJ
  9. Frontiers in microbiology
  10. Molecules (Basel, Switzerland)
  11. Pathology, research and practice
  12. Chemico-biological interactions
  13. Genes
  14. Alternative medicine review : a journal of clinical therapeutic
  15. Food & function
  16. Molecular biology reports
  17. American journal of translational research
  18. Journal of microbiology and biotechnology
  19. Molecular medicine reports
  20. Phytomedicine : international journal of phytotherapy and phytopharmacology
  21. Journal of microorganism control
  22. Dose-response : a publication of International Hormesis Society
  23. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
  24. Anti-cancer agents in medicinal chemistry
  25. Nature communications
  26. Fitoterapia
  27. International immunopharmacology
  28. Guang pu xue yu guang pu fen xi = Guang pu

Coptisine

  1. Dr. Duke
  2. Journal of chromatographic science
  3. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
  4. Drug testing and analysis
  5. European journal of pharmacology
View 18 additional sources
  1. Journal of ethnopharmacology
  2. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  3. Journal of natural medicines
  4. PeerJ
  5. Frontiers in plant science
  6. Pathology, research and practice
  7. Molecules (Basel, Switzerland)
  8. Planta medica
  9. Microbiology spectrum
  10. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  11. Journal of pharmaceutical and biomedical analysis
  12. Pharmaceutical biology
  13. Journal of microorganism control
  14. Dose-response : a publication of International Hormesis Society
  15. Frontiers in pharmacology
  16. Chinese journal of natural medicines
  17. International journal of molecular sciences
  18. Ecotoxicology and environmental safety

Palmatine

  1. Dr. Duke
  2. European journal of drug metabolism and pharmacokinetics
  3. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
  4. Archives of virology
  5. Drug testing and analysis
View 16 additional sources
  1. Yao xue xue bao = Acta pharmaceutica Sinica
  2. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  3. Journal of chromatographic science
  4. Frontiers in plant science
  5. Pathology, research and practice
  6. Planta medica
  7. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  8. Pharmaceutical biology
  9. Molecules (Basel, Switzerland)
  10. Journal of microorganism control
  11. Dose-response : a publication of International Hormesis Society
  12. Frontiers in pharmacology
  13. Chinese journal of natural medicines
  14. International journal of molecular sciences
  15. Ecotoxicology and environmental safety
  16. Toxicology in vitro : an international journal published in association with BIBRA

Epiberberine

  1. Drug testing and analysis
  2. Journal of pharmaceutical and biomedical analysis
  3. Journal of chromatographic science
  4. PeerJ
  5. Frontiers in plant science
View 9 additional sources
  1. Planta medica
  2. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  3. Pharmaceutical biology
  4. Journal of microorganism control
  5. Frontiers in pharmacology
  6. Chinese journal of natural medicines
  7. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  8. Ecotoxicology and environmental safety
  9. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

Jatrorrhizine

  1. Journal of pharmaceutical and biomedical analysis
  2. Drug testing and analysis
  3. Yao xue xue bao = Acta pharmaceutica Sinica
  4. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  5. The Journal of pharmacy and pharmacology
View 6 additional sources
  1. Journal of microorganism control
  2. Frontiers in plant science
  3. Frontiers in pharmacology
  4. Chinese journal of natural medicines
  5. International journal of molecular sciences
  6. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

Columbamine

  1. Dr. Duke
  2. Journal of chromatographic science
  3. Drug testing and analysis
  4. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  5. Planta medica
View 2 additional sources
  1. Microbiology spectrum
  2. Pharmaceutical biology

Berberine hydrochloride

  1. Journal of chromatographic science
  2. Scientific reports
  3. Nihon yakurigaku zasshi. Folia pharmacologica Japonica
  4. Biomolecules

Jatrorrhizin

  1. PeerJ
  2. Frontiers in plant science
  3. Luminescence : the journal of biological and chemical luminescence

Magnoflorine

  1. Dr. Duke
  2. Drug testing and analysis
  3. Frontiers in pharmacology

Palmatine chloride

  1. Journal of chromatographic science
  2. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
  3. Microbiology spectrum

Activities

Coptis chinensis has 307 reported activities identified across 20 scientific publications and several other databases. The most consistently reported activities include Antibacterial, Antioxidant, Anticancer, Hypoglycemic, Hypolipidemic.

Most Reported Activities

Activity Sources Consensus
Antibacterial Dr. Duke (and other 5 sources) ★★★☆☆
Antioxidant Dr. Duke (and other 4 sources) ★★☆☆☆
Anticancer Dr. Duke (and other 2 sources) ★☆☆☆☆
Hypoglycemic Dr. Duke (and other 2 sources) ★☆☆☆☆
Hypolipidemic Dr. Duke (and other 2 sources) ★☆☆☆☆
(+)-Inotropic Dr. Duke (and other 1 sources) ★☆☆☆☆
ACE-Inhibitor Dr. Duke (and other 1 sources) ★☆☆☆☆
Abortifacient Dr. Duke (and other 1 sources) ★☆☆☆☆
Adrenocorticotrophic Dr. Duke (and other 1 sources) ★☆☆☆☆
Adrenolytic Dr. Duke (and other 1 sources) ★☆☆☆☆

Medicinal Uses

Coptis chinensis has 64 reported medicinal uses identified across 20 scientific publications and several other databases. The most consistently reported uses include Alzheimer's disease, obesity, breast cancer, diabetes mellitus, gastritis.

Most Reported Uses

Use Sources Consensus
Alzheimer's disease Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (and other 4 sources) ★★☆☆☆
obesity American journal of translational research (and other 4 sources) ★★☆☆☆
breast cancer Carcinogenesis (and other 3 sources) ★★☆☆☆
diabetes mellitus Chinese journal of integrative medicine (and other 3 sources) ★★☆☆☆
gastritis Journal of ethnopharmacology (and other 3 sources) ★★☆☆☆
cancer Carcinogenesis (and other 2 sources) ★☆☆☆☆
gastric ulcer Journal of ethnopharmacology (and other 2 sources) ★☆☆☆☆
gastric ulcers Journal of natural medicines (and other 2 sources) ★☆☆☆☆
hyperglycemia Frontiers in pharmacology (and other 2 sources) ★☆☆☆☆
hypertension Chemico-biological interactions (and other 2 sources) ★☆☆☆☆

Preparations

Preparations Sources Consensus
Berberine (BBR) Endocrinology (and other 4 sources) ★★☆☆☆
aqueous extracts Journal of pharmaceutical and biomedical analysis (and other 4 sources) ★★☆☆☆
Berberine hydrochloride Scientific reports (and other 2 sources) ★☆☆☆☆
aqueous extract Molecules (Basel, Switzerland) (and other 2 sources) ★☆☆☆☆
CEXs Archives of pharmacal research (and other 1 sources) ★☆☆☆☆
Coptis chinensis decoction Mikrochimica acta (and other 1 sources) ★☆☆☆☆
Coptis chinensis extracts Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (and other 1 sources) ★☆☆☆☆
Extracts Life sciences (and other 1 sources) ★☆☆☆☆
Fractionated Coptis chinensis Extract Journal of microbiology and biotechnology (and other 1 sources) ★☆☆☆☆
HL extract Journal of ethnopharmacology (and other 1 sources) ★☆☆☆☆