Clematis cirrhosa
Clematis cirrhosa · Accepted scientific name
Scientific literature: Very Sparse (2 studies) · ★☆☆☆☆
Clematis cirrhosa is a plant species that has gained significant scientific interest due to its diverse pharmacological potential. Research into its various preparations, including ethanol extracts, aqueous extracts, and CEE, has revealed a complex profile of bioactive constituents. These include specialized chemicals such as Calceolarioside B, fatty acids, Manghaslin, and Salvadoraside. Studies indicate that these compounds exhibit notable antiproliferative and cytotoxic activities when applied to various biological models. Specifically, the plant demonstrates the ability to influence critical physiological conditions such as apoptosis and angiogenesis.
- Synonyms
- Clematis Cirrhosa Var. Obtusifolia · Clematis Cirrhosa F. Semitriloba · 35 more
- Common names
- Not available
- Family
- Ranunculaceae
- Distribution
- Not available
- Plant Parts
- Not available
Classification
Common Names
Clematis cirrhosa is a versatile climbing plant known by a diverse array of names across different languages and regions. In English-speaking botanical circles, it is frequently referred to as the Early Virgin's-bower. Its linguistic variety extends into French, where it is commonly called Clématite à vrilles or Clematite cirrheuse. In other contexts, the species may be identified by the name Clematide cirrosa. Finally, the plant is also recognized by its Turkish common name, Bahar Sarmaşığı.
Sources: Catalogue of Life (COL)
Synonyms
Clematis cirrhosa is a botanical subject known to be associated with several distinct taxonomic synonyms. Within various scientific records, this plant is frequently identified by the names Atragene balearica and Atragene cirrhosa. It is also documented under the names Cheiropsis balearica and Cheiropsis cirrhosa, reflecting different historical classifications. Furthermore, the synonym Cheiropsis elegans is often linked to this species in botanical literature. Understanding these overlapping names is essential for researchers tracking the plant's formal identity.
Sources: The World Checklist of Vascular Plants (WCVP)
Taxonomy
Clematis cirrhosa belongs to the vast kingdom Plantae, representing the diverse life of the botanical world. Within this kingdom, the species is classified under the class Equisetopsida. It further falls into the order Ranunculales, which helps define its evolutionary lineage. As a member of the family Ranunculaceae, it shares structural traits with many other buttercup-like plants. Ultimately, this flowering vine is distinguished by its placement within the genus Clematis.
| Rank | Classification |
|---|---|
| Kingdom | Plantae |
| Phylum | Streptophyta |
| Class | Equisetopsida |
| Subclass | Magnoliidae |
| Order | Ranunculales |
| Family | Ranunculaceae |
| Genus | Clematis |
Sources: The World Checklist of Vascular Plants (WCVP)
Distribution
Geographic Regions
Clematis cirrhosa exhibits a diverse geographic range that spans across two distinct continents. In the African region, this plant is widely distributed throughout Northern Africa, specifically inhabiting the landscapes of Algeria, Libya, Morocco, and Tunisia. Its reach extends beyond the African continent into the temperate zones of Asia. Within Western Asia, the species can be found flourishing in the unique environment of Cyprus. This wide distribution highlights the plant's ability to adapt to various Mediterranean and temperate climates.
Sources: The World Checklist of Vascular Plants (WCVP)
Identification
Morphology
Clematis cirrhosa exhibits a distinct shrub-like growth form as it matures. This species relies on an obligatory climbing habit to ascend and thrive within its environment.
Sources: Global Inventory of Floras and Traits (GIFT)
Biological Activities
Clematis cirrhosa has demonstrated significant biological potential through its documented cytotoxic and antiproliferative activities. Recent research highlights that the ethanol extract of this plant is effective against HT-29 colorectal cancer cells by inducing G2/M phase cell cycle arrest. This extract further triggers significant apoptosis and inhibits essential processes such as cell migration and angiogenesis. Chemical profiling and molecular docking studies suggest that specific metabolites within the plant contribute to these therapeutic effects by targeting key apoptotic markers. Ultimately, these findings position Clematis cirrhosa as a promising candidate for further investigation in the development of cancer therapies.
Compounds
Clematis cirrhosa is a plant species that has shown significant promise in medical research due to its diverse chemical profile. Detailed LC-ESI-QTOF-MS/MS analysis reveals that the plant contains several key metabolites, including manghaslin and luteolin. Furthermore, the ethanol extract of this species is characterized by the presence of calceolarioside B and salvadoraside. Molecular docking studies also identified tectoridin as a notable constituent within the plant's complex makeup. Together, these specific compounds contribute to the observed biological activities that make Clematis cirrhosa a candidate for cancer therapy.
Conditions
Clematis cirrhosa demonstrates significant therapeutic potential by inducing G2/M phase cell cycle arrest in colorectal cancer cells. The plant extract also exhibits effective antifungal activity against the dermatophyte T. violaceum. Furthermore, it serves to restrain angiogenesis through the reduction of VEGF mRNA expression. The ethanol extract promotes apoptosis by increasing the expression of proapoptotic markers like BAX and caspase-3. Finally, Clematis cirrhosa inhibits cell migration and wound healing processes, contributing to its antiproliferative effects.
Preparations
Clematis cirrhosa is prepared as CEE, which is a specific term used to denote its ethanol extract. Research further specifies that Clematis cirrhosa is prepared as an ethanol extract to study its cytotoxic effects and chemical profiling. Additionally, the plant is prepared as aqueous extracts for investigating its antifungal activity against various dermatophytes. These different preparation methods, including the use of an ethanol extract, allow for the exploration of the plant's diverse medicinal properties. Through these specific preparations, the therapeutic potential of Clematis cirrhosa can be thoroughly evaluated in both cancer and fungal studies.