Greater celandine

Chelidonium majus · Accepted scientific name

Scientific literature: Very Extensive (545 studies) · ★★★★★

Greater celandine, scientifically known as Chelidonium majus, is a perennial herbaceous plant renowned for its bright yellow, latex-rich sap. Traditionally used in herbal medicine to treat skin conditions and liver ailments, it contains potent alkaloids. However, its high toxicity requires cautious application and expert guidance during medicinal use.

Family
Papaveraceae
Native range
Europe
Parts used
Root
Common names
Celandine · Greater Celandine · 5 more
Scientific synonyms
Not available

Names and Synonyms

Common Names

Scientific Names

Accepted name

Chelidonium majus

Regional and Traditional Names

Spanish:

  • Pedigueña
  • Verrugera
  • Chiledonia
  • Celiduena
  • Ceredueña
  • Ceridueña
  • Hierba golondrinera
  • Ciledonia
  • Cerigueña
  • Cilidueña
  • Pediguena
  • Cirigueña
  • Cerdueña
  • Hierba de las golondrinas
  • Hirundinaria
  • Ceredonia
  • dilidonia
  • flor de la golondrina
  • golondrinera
  • gran luz
  • cedueña
  • celdueña
  • celedonia
  • celedonio
  • celidoña
  • celidonia
  • celidonia mayor
  • celidueña
  • celidueña fina
  • cerdoña
  • ceridoña
  • ceridonia
  • cerigüeña
  • ceruda
  • cevuda
  • cilidonia
  • cirgüeña
  • ciridueña
  • cirigüeña
  • cirigüeya
  • cirirueña
  • pedigüeña
  • piohuelo
  • planta del yodo
  • quitaverrugas
  • selidonia
  • verruguera
  • yerba de las golondrinas
  • yerba del pordiosero
  • yerba verruguera
  • yeteira
  • hierba de la golondrina
  • hierba de las verrugas
  • hierba del iodo
  • hierba verruguera
  • celidonia mayor

German:

  • Schöllkraut
  • Schellkraut
  • grande chélidoine
  • Schöllkraut
  • Gewöhnliches Schöllkraut
  • Schoellkraut
  • Warzenkraut

French:

  • Verrucaire
  • Grande chélidoine
  • Quélidoine
  • Herbe aux verrues
  • Chélidoine
  • Chelidoine
  • Herbe à verrues
  • Kélidoine
  • chélidoine
  • chélidoine herbe-aux-verrues
  • chélidoine majeure
  • grande chélidoine
  • grande éclaire
  • herbe aux verrues
  • éclaire
  • Chelidoine
  • Herbe-aux-verrues

Sources: Wikidata, Catalogue of Life

Taxonomical Classification

This plant belongs to the kingdom Plantae and is classified under the phylum Streptophyta and class Equisetopsida. Within the subclass Magnoliidae, it is further organized under the order Ranunculales and the family Papaveraceae. Finally, its specific taxonomic identity is defined by the genus Chelidonium.

Rank Classification
Kingdom Plantae
Phylum Streptophyta
Class Equisetopsida
Subclass Magnoliidae
Order Ranunculales
Family Papaveraceae
Genus Chelidonium

Sources: The World Checklist of Vascular Plants (WCVP)

Distribution

This plant exhibits a specific geographical distribution across several regions in Northern Europe. It can be found growing within the borders of Denmark and Finland. Furthermore, its presence extends to the islands of Great Britain and Ireland. The species is also documented as occurring in Norway. Together, these locations define its northern European habitat.

Region Area
Northern Europe Denmark
Northern Europe Finland
Northern Europe Great Britain
Northern Europe Ireland
Northern Europe Norway
Northern Europe Sweden
Middle Europe Austria
Middle Europe Belgium
Middle Europe Czechia-Slovakia
Middle Europe Germany

Sources: The World Checklist of Vascular Plants (WCVP)

Botanical Identification

Ecology

The ecology of Chelidonium majus is characterized by its broad adaptability across varying altitudinal gradients, spanning from sea level up to a maximum elevation of 2200 m AMSL. It is most frequently observed in lowland habitats, though it maintains a significant presence throughout middle elevations, with a mean elevational range centered around 1350 m AMSL. This wide distribution allows the species to occupy diverse ecological niches across a diverse range of vertical landscapes.

Elevational range max:
2200 m AMSL
Elevational range mean:
1350 m AMSL
Elevational range min:
0 m AMSL
Habitat :
Lowland

Life history

The life history of Chelidonium majus is characterized by its status as a perennial plant, allowing it to persist through multiple growing seasons. It functions as a hemicryptophyte, a life form where the perennating buds are located at the soil surface, protected by leaf litter or soil cover during unfavorable periods. Furthermore, the species exhibits a deciduous nature, shedding its foliage annually as it transitions through its seasonal cycles.

Deciduousness :
deciduous
Life form :
hemicryptophyte
Lifecycle :
perennial

Morphology

The morphology of Chelidonium majus is characterized by a growth form classified as both a herb and a forb. It is a terrestrial, non-woody plant that functions as an independent organism rather than a parasite or epiphyte. The plant typically exhibits an erect shoot orientation and is self-supporting, lacking any climbing or vine-like tendencies. In terms of stature, it maintains a relatively low profile, with a plant height that ranges from a minimum of 0.3 m to a maximum of 1 m, resulting in a mean height of approximately 0.5057 m.

Aquatic :
terrestrial
Climber :
self-supporting
Epiphyte :
terrestrial
Growth form :
herb
Growth form :
forb
Parasite :
independent
Plant height max:
1 m
Plant height mean:
0.505666666666667 m
Plant height min:
0.3 m
Shoot orientation :
erect
Woodiness :
non-woody

Physiology

The physiology of Chelidonium majus is characterized by a C3 photosynthetic pathway and a non-carnivorous nutritional strategy. Its foliage exhibits significant morphological diversity, featuring a pinnate leaf form with a mean leaf size of 92.26 cm². The leaf dimensions vary considerably, with a mean leaf length of 5 cm (ranging from a minimum of 2 cm to a maximum of 20 cm) and a mean leaf width of 8 cm (ranging from a minimum of 1 cm to a maximum of 10 cm). Furthermore, the plant maintains a mean Specific Leaf Area (SLA) of 426.08 cm²/g, reflecting its leaf mass per area and its physiological adaptation to its specific ecological niche.

Carnivory :
non-carnivorous
Leaf form :
pinnate
Leaf length max:
20 cm
Leaf length mean:
5 cm
Leaf length min:
2 cm
Leaf size mean:
92.26 cm²
Leaf width max:
10 cm
Leaf width mean:
8 cm
Leaf width min:
1 cm
Photosynthetic pathway :
C3
Specific Leaf Area (SLA) mean:
426.08 cm²/g

Reproduction

The reproduction of Chelidonium majus is characterized by a sexual process through bisexual flowers, with asexual reproduction being absent. The flowering period typically commences in May and concludes in July, featuring yellow flowers that range in length from 0.7 cm to 1.2 cm. These flowers utilize a biotic pollination syndrome, primarily relying on insects, specifically bees, to facilitate fertilization; notably, self-fertilization is present. Following successful pollination, the plant develops dry fruit in the form of capsules. These capsules vary in size, with an average length of 3.5 cm (ranging from 2 cm to 5 cm) and an average width of 0.25 cm (ranging from 0.2 cm to 0.3 cm). Each fruit is prolific, containing between 101 and 1000 seeds. The seeds themselves are quite small, with a mean mass of approximately 0.000732889 g (ranging from 0.00051 g to 0.00091 g), a length between 1 mm and 1.5 mm, and a consistent volume of 0.47 mm³. Seed dispersal follows a zoochorous syndrome, specifically exhibiting myrmecochorous traits, indicating that ants play a role in the dispersal of the seeds.

Dispersal syndrome :
zoochorous
Dispersal syndrome :
myrmecochorous
Flower colour :
yellow
Flower length max:
1.2 cm
Flower length min:
0.7 cm
Flowering time :
May
Flowering time :
Jul
Fruit dryness :
dry
Fruit length max:
5 cm
Fruit length mean:
3.5 cm
Fruit length min:
2 cm
Fruit type :
capsule
Fruit width max:
0.3 cm
Fruit width mean:
0.25 cm
Fruit width min:
0.2 cm
Pollination syndrome :
insect
Pollination syndrome :
bee
Pollination syndrome :
biotic
Reproduction asexual :
absent
Reproduction sexual :
bisexual
Seed length max:
1.5 mm
Seed length min:
1 mm
Seed mass max:
0.00091 g
Seed mass mean:
0.000732889 g
Seed mass min:
0.00051 g
Seed volume max:
0.47 mm³
Seeds_per_fruit :
101-1000
Self fertilization :
present

Sources: Global Inventory of Floras and Traits (GIFT)

Plant Parts

Chelidonium majus has 1 reported plant parts identified across 1 scientific publications and several other databases that are studied for medicinal purposes. The most consistently reported plant part include root.

Plant parts reported in Chelidonium majus
Plant part Supporting sources Consensus
Root 1 supporting sources ★☆☆☆☆

Root

  1. Toxins

Chemicals

Chelidonium majus has 81 reported phytochemicals identified across 1 scientific publications and several other databases. The most consistently reported chemicals include SANGUINARINE, CHELIDONINE, chelerythrine, Coptisine, protopine.

Chemicals reported in Chelidonium majus
Chemical Supporting sources Consensus
SANGUINARINE 15 supporting sources ★★★★★
CHELIDONINE 13 supporting sources ★★★★★
chelerythrine 12 supporting sources ★★★★★
Coptisine 8 supporting sources ★★★★☆
protopine 7 supporting sources ★★★★☆
berberine 6 supporting sources ★★★☆☆
Allocryptopine 4 supporting sources ★★☆☆☆
Dihydrosanguinarine 3 supporting sources ★★☆☆☆
Stylopine 3 supporting sources ★★☆☆☆
8-Hydroxydihydrochelerythrine 2 supporting sources ★☆☆☆☆

SANGUINARINE

  1. Dr. Duke
  2. Planta medica
  3. Journal of ethnopharmacology
  4. Molecules (Basel, Switzerland)
  5. Toxins
View 10 additional sources
  1. Talanta
  2. PloS one
  3. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  4. Phytomedicine : international journal of phytotherapy and phytopharmacology
  5. Tsitologiia
  6. Frontiers in pharmacology
  7. Journal of chromatography. A
  8. Journal of mass spectrometry : JMS
  9. Oxidative medicine and cellular longevity
  10. Neurochemistry international

CHELIDONINE

  1. Dr. Duke
  2. Planta medica
  3. Molecules (Basel, Switzerland)
  4. Journal of biochemical and molecular toxicology
  5. Georgian medical news
View 8 additional sources
  1. Cancer letters
  2. Phytomedicine : international journal of phytotherapy and phytopharmacology
  3. Tsitologiia
  4. Frontiers in pharmacology
  5. Journal of chromatography. A
  6. Toxins
  7. Journal of mass spectrometry : JMS
  8. Oxidative medicine and cellular longevity

chelerythrine

  1. Dr. Duke
  2. Planta medica
  3. Journal of ethnopharmacology
  4. Molecules (Basel, Switzerland)
  5. Talanta
View 7 additional sources
  1. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  2. Phytomedicine : international journal of phytotherapy and phytopharmacology
  3. Frontiers in pharmacology
  4. Journal of chromatography. A
  5. Toxins
  6. Journal of mass spectrometry : JMS
  7. Neurochemistry international

Coptisine

  1. Dr. Duke
  2. Molecules (Basel, Switzerland)
  3. Phytochemistry
  4. Planta medica
  5. Phytomedicine : international journal of phytotherapy and phytopharmacology
View 3 additional sources
  1. Frontiers in pharmacology
  2. Journal of chromatography. A
  3. Journal of mass spectrometry : JMS

protopine

  1. Dr. Duke
  2. Molecules (Basel, Switzerland)
  3. Phytomedicine : international journal of phytotherapy and phytopharmacology
  4. Planta medica
  5. Journal of chromatography. A
View 2 additional sources
  1. Journal of mass spectrometry : JMS
  2. Oxidative medicine and cellular longevity

berberine

  1. Dr. Duke
  2. Molecules (Basel, Switzerland)
  3. Journal of separation science
  4. Frontiers in pharmacology
  5. Journal of chromatography. A
View 1 additional sources
  1. Neurochemistry international

Allocryptopine

  1. Dr. Duke
  2. Molecules (Basel, Switzerland)
  3. Planta medica
  4. Journal of chromatography. A

Dihydrosanguinarine

  1. Dr. Duke
  2. Journal of ethnopharmacology
  3. Georgian medical news

Stylopine

  1. Dr. Duke
  2. Planta medica
  3. Journal of chromatography. A

8-Hydroxydihydrochelerythrine

  1. Journal of ethnopharmacology
  2. Molecules (Basel, Switzerland)

Activities

Chelidonium majus has 254 reported activities identified across 1 scientific publications and several other databases. The most consistently reported activities include Antimicrobial, Anticancer, Antioxidant, Analgesic, Antiviral.

Activities reported in Chelidonium majus
Activity Supporting sources Consensus
Antimicrobial 5 supporting sources ★★★☆☆
Anticancer 4 supporting sources ★★☆☆☆
Antioxidant 4 supporting sources ★★☆☆☆
Analgesic 3 supporting sources ★★☆☆☆
Antiviral 3 supporting sources ★★☆☆☆
Antibacterial 2 supporting sources ★☆☆☆☆
Antineoplastic 2 supporting sources ★☆☆☆☆
Antispasmodic 2 supporting sources ★☆☆☆☆
Antitussive 2 supporting sources ★☆☆☆☆
Cholagogue 2 supporting sources ★☆☆☆☆

Antimicrobial

  1. Plants (Basel, Switzerland)
  2. Pharmaceutics
  3. European review for medical and pharmacological sciences
  4. Materials (Basel, Switzerland)
  5. Frontiers in pharmacology

Anticancer

  1. Dr. Duke
  2. Plants (Basel, Switzerland)
  3. Pharmaceutics
  4. Frontiers in pharmacology

Antioxidant

  1. Dr. Duke
  2. Plants (Basel, Switzerland)
  3. Pharmaceutics
  4. Food technology and biotechnology

Analgesic

  1. Dr. Duke
  2. Journal of biochemical and molecular toxicology
  3. European review for medical and pharmacological sciences

Antiviral

  1. Dr. Duke
  2. Plants (Basel, Switzerland)
  3. Frontiers in pharmacology

Antibacterial

  1. Dr. Duke
  2. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Antineoplastic

  1. Dr. Duke
  2. European review for medical and pharmacological sciences

Antispasmodic

  1. Dr. Duke
  2. Planta medica

Antitussive

  1. Dr. Duke
  2. European review for medical and pharmacological sciences

Cholagogue

  1. Dr. Duke
  2. Frontiers in pharmacology

Conditions

Chelidonium majus has 44 reported investigations on conditions identified across 1 scientific publications and several other databases. The most consistently reported conditions include cancer, analgesic, irritable bowel syndrome, tumor, Bacillus subtilis.

Conditions investigated for Chelidonium majus
Condition Supporting sources Consensus
Cancer 5 supporting sources ★★★☆☆
Analgesic 3 supporting sources ★★☆☆☆
Irritable bowel syndrome 2 supporting sources ★☆☆☆☆
Tumor 2 supporting sources ★☆☆☆☆
Bacillus subtilis 1 supporting sources ★☆☆☆☆
Cancer 1 supporting sources ★☆☆☆☆
Endometriosis 1 supporting sources ★☆☆☆☆
Fusarium 1 supporting sources ★☆☆☆☆
Melanoma 1 supporting sources ★☆☆☆☆
Antineoplastic 1 supporting sources ★☆☆☆☆

Cancer

  1. International journal of biological macromolecules
  2. Fitoterapia
  3. Frontiers in pharmacology
  4. Phytotherapy research : PTR
  5. Phytomedicine : international journal of phytotherapy and phytopharmacology

Analgesic

  1. Journal of biochemical and molecular toxicology
  2. European review for medical and pharmacological sciences
  3. Chemico-biological interactions

Irritable bowel syndrome

  1. Gastro hep advances
  2. Phytomedicine : international journal of phytotherapy and phytopharmacology

Tumor

  1. Journal of ethnopharmacology
  2. Journal of chromatography. A

Bacillus subtilis

  1. Journal of chromatography. A

Cancer

  1. Oxidative medicine and cellular longevity

Endometriosis

  1. Pharmaceutics

Fusarium

  1. Journal of ethnopharmacology

Melanoma

  1. Molecules (Basel, Switzerland)

Antineoplastic

  1. European review for medical and pharmacological sciences

Preparations

Chelidonium majus has 21 reported preparations identified across 1 scientific publications and several other databases. The most consistently reported preparations include extracts, C. majus extract, extract, 75% ethanol extract, Ethanolic extracts.

Preparations reported for Chelidonium majus
Preparation Supporting sources Consensus
Extracts 6 supporting sources ★★★☆☆
C. majus extract 2 supporting sources ★☆☆☆☆
Extract 2 supporting sources ★☆☆☆☆
75% ethanol extract 1 supporting sources ★☆☆☆☆
Ethanolic extracts 1 supporting sources ★☆☆☆☆
H2 1 supporting sources ★☆☆☆☆
H3 1 supporting sources ★☆☆☆☆
Root extract 1 supporting sources ★☆☆☆☆
Aerial parts 1 supporting sources ★☆☆☆☆
Aerial parts extract 1 supporting sources ★☆☆☆☆

Extracts

  1. Molecules (Basel, Switzerland)
  2. Talanta
  3. Arzneimittel-Forschung
  4. Toxins
  5. Pathogens (Basel, Switzerland)
View 1 additional sources
  1. Neurochemistry international

C. majus extract

  1. Molecules (Basel, Switzerland)
  2. Planta medica

Extract

  1. Sangre
  2. Journal of ethnopharmacology

75% ethanol extract

  1. Fitoterapia

Ethanolic extracts

  1. Bioscience, biotechnology, and biochemistry

H2

  1. Parasites & vectors

H3

  1. Parasites & vectors

Root extract

  1. Toxins

Aerial parts

  1. Fitoterapia

Aerial parts extract

  1. Toxins