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Updated: Oct 20, 2024

What to know about Centella asiatica before using it medicinally

Centella asiatica plant

Centella asiatica, commonly known as gotu kola, is a medicinal herb that has been used to treat various health conditions, including anxiety, depression, and insomnia, as well as skin conditions such as eczema and acne.

The herb is also used to improve cognitive function, memory, and concentration, making it a popular ingredient in nootropics and brain-boosting supplements. The main health benefits of Centella asiatica include its anti-inflammatory, antioxidant, and antiviral properties, which contribute to its ability to promote wound healing, reduce scarring, and improve overall skin health. The herb's therapeutic properties are attributed to its triterpenoid saponins, flavonoids, and phenolic acids, which have been shown to have anti-inflammatory, antimicrobial, and antioxidant effects.

Traditionally, people make an herbal tea by infusing the leaves of Centella asiatica in hot water, which is then consumed to reap the benefits of the herb.

The following article explains in detail what are the medicinal uses of Centella asiatica, its health benefits, therapeutic properties, bioactive compounds, used parts, and herbal preparation. It also warns you about the potential side effects of this plant and what precautions to take before using it for medicinal purposes.

ARTICLE SUMMARY: The table below summarizes the most crucial information about Centella asiatica provided in the article below, which is useful if you are in a hurry and don't have time to dig deep into the very detailed content that follows.

Medicinal AspectSummary
UsesMemory loss, Diabetes, Hypertension, Eczema, Anxiety, Psoriasis, Dementia, Inflammation, Osteoarthritis, Alzheimer's
BenefitsImproves cognitive, Reduces inflammation, Enhances memory, Protects liver, Promotes wound, Reduces anxiety, Improves skin, Enhances cognitive, Supports eye, Boosts immune
PropertiesAntimicrobial, Antioxidant, Anti-inflammatory, Antibacterial, Antifungal, Antiviral, Antihistamine, Neuroprotective, Wound healing, Immunomodulatory
ConstituentsFlavonoids, Triterpenoids, Saponins, Phenolic acids, Madecassoside, Asiatic acid, Alkaloids, Glycosides, Asiaticoside, Triterpene saponins
PartsLeaves, Roots, Rhizomes
PreparationsCapsule, Tincture, Salve, Tea, Decoction, Essential oil
Side EffectsExacerbate, Interact, Amplify, Provoke, Aggravate, Induce, Trigger, Potentiate, Enhance, Disrupt
PrecautionConsult a doctor before use, Monitor blood pressure, Avoid in pregnancy and breastfeeding, Use under medical supervision, Report allergies, Avoid interactions with medications, Start with low doses, Monitor liver function, Avoid excessive consumption, Follow proper preparation methods

BONUS CHEATSHEET: The cheatsheet below illustrates the most important medicinal aspects of Centella asiatica. Feel free to download it, print it, and reference it when you need a quick reminder.

Centella asiatica plant cheatsheet

What are the main medicinal uses of Centella asiatica?

The main medicinal uses of Centella asiatica are its efficacy in treating memory loss due to its content of asiaticoside, brahmoside, and madecassoside, which have been shown to enhance memory and cognitive function by modulating the activity of neurotransmitters.

Centella asiatica also has a significant role in wound healing, attributed to the presence of triterpenoid saponins, which stimulate collagen synthesis and enhance the proliferation of fibroblasts, thereby promoting tissue repair. Furthermore, the plant's antioxidant and anxiolytic properties, largely due to the action of flavonoids and phenolic acids, make it an effective treatment for anxiety and stress-related disorders. Additionally, Centella asiatica has been used to address hair loss by stimulating hair growth and improving scalp health, thanks to the presence of madecassic acid and asiatic acid, which have been shown to enhance the activity of 5-alpha-reductase inhibitors.

Centella asiatica has also been used to treat a range of conditions, including diabetes, skin conditions such as eczema, digestive issues, inflammation, and Alzheimer's disease, all of which are attributed to the plant's rich content of triterpenoid saponins, flavonoids, and phenolic acids.

The following illustration give a summary of the main medicinal uses of Centella asiatica.

uses of Centella asiatica

The list below provide more details on why Centella asiatica is used to alleviate the health conditions mentioned in the illustration above.

The table that follows gives an overview of what are the most common health conditions that are treated with Centella asiatica, in each of the major medicinal systems.

Medicinal SystemConditions Treated
Modern Western MedicineHypertension, Memory Loss, Anxiety Disorder, Diabetes, Skin Inflammation, Eczema, Alzheimer'S, Parkinson'S Disease, Hepatitis, Wound Healing, Traumatic Brain Injury, Psoriasis, Dementia, Stroke, Depression, Osteoarthritis, Gastritis, Chronic Fatigue, Multiple Sclerosis, Neurodegenerative Diseases
Traditional Chinese MedicineMemory Loss, Hypertension, Diabetes, Anxiety, Eczema, Psoriasis, Dementia, Inflammation, Stress, Stroke, Wound Healing, Fatigue, Osteoarthritis, Depression, Arthritis, Skin Inflammation, Alzheimer'S, Gastritis, Parkinson'S, Neurodegenerative Diseases
Ayurvedic MedicineMemory Loss, Diabetes, Eczema, Hypertension, Anxiety, Psoriasis, Digestive Issues, Inflammation, Hair Loss, Alzheimer'S, Parkinson'S Disease, Insomnia, Dementia, Osteoporosis, Stroke, Skin Lesions, Gastrointestinal Issues, Alzheimer'S Disease, Neurodegenerative Diseases, Anxiety Disorder
Unani MedicineMemory Loss, Diabetes, Eczema, Hypertension, Psoriasis, Anxiety, Osteoarthritis, Epilepsy, Hyperlipidemia, Chronic Fatigue, Skin Ulcers, Hair Loss, Osteoporosis, Skin Infections, Alopecia, Rheumatism, Varicose Veins, Insomnia, Hemorrhoids, Dementia
Homeopathic MedicineHypertension, Memory Loss, Diabetes Complications, Anxiety, Eczema, Hiv Inflammation, Dementia, Psoriasis, Parkinson'S, Alzheimer'S, Stress, Rheumatoid Arthritis, Gastritis, Skin Conditions, Depression, Wound Healing, Gastrointestinal Issues, Skin Inflammation, Hyperlipidemia, Digestive Issues

Modern Western Medicine

In modern western medicine, Centella asiatica is used to treat hypertension by reducing blood pressure through its vasodilatory effect.

Additionally, it has been employed to address memory loss by enhancing cognitive function and neuronal plasticity. Furthermore, Centella asiatica has been found to have anxiolytic properties, reducing anxiety disorder symptoms by modulating the GABAergic system. Its potential therapeutic applications also extend to diabetes management, where it has been shown to improve insulin sensitivity and glucose metabolism.

The plant's anti-inflammatory and antioxidant properties have made it a valuable treatment option for skin inflammation, eczema, Alzheimer's, Parkinson's disease, hepatitis, wound healing, traumatic brain injury, psoriasis, dementia, stroke, depression, osteoarthritis, gastritis, chronic fatigue, multiple sclerosis, and neurodegenerative diseases, while also promoting liver health and enhancing the body's ability to heal from injury.

Traditional Chinese Medicine

In traditional chinese medicine, Centella asiatica is used to treat memory loss and dementia by enhancing cognitive function and neuroplasticity.

It also helps manage hypertension and stroke by reducing blood pressure and preventing vascular damage. Additionally, Centella asiatica is used to treat diabetes, anxiety, eczema, and psoriasis by regulating blood sugar levels, reducing oxidative stress, and modulating the immune response. Furthermore, it is used to alleviate inflammation, stress, fatigue, osteoarthritis, depression, arthritis, skin inflammation, and gastritis by reducing pro-inflammatory cytokines, regulating the hypothalamic-pituitary-adrenal axis, and promoting wound healing.

Centella asiatica is also used to treat neurodegenerative diseases, including Alzheimer's, Parkinson's, and Alzheimer's-related conditions, by protecting neurons and preventing neuroinflammation.

Ayurvedic Medicine

In ayurvedic medicine, Centella asiatica is used to treat memory loss due to its antioxidant properties and ability to improve cognitive function.

The plant's anti-inflammatory and antioxidant compounds also help manage diabetes by reducing oxidative stress and improving insulin sensitivity. Centella asiatica is also applied topically to treat eczema and other skin conditions like psoriasis, which are characterized by inflammation and skin lesions. Additionally, the plant is used to lower hypertension and alleviate anxiety by reducing stress and promoting relaxation, while its anti-inflammatory properties also help with digestive issues and inflammation.

Furthermore, Centella asiatica is used to prevent hair loss and promote hair growth, as well as to treat neurodegenerative diseases such as Alzheimer's and Parkinson's disease, insomnia, dementia, osteoporosis, stroke, and anxiety disorders.

Unani Medicine

In unani medicine, Centella asiatica is used to treat various health conditions, including memory loss due to its ability to improve cognitive function by enhancing blood flow to the brain.

Centella asiatica has also been used to manage diabetes by regulating blood sugar levels and improving insulin sensitivity, as well as eczema by reducing inflammation and promoting wound healing. Furthermore, it has been employed in the treatment of hypertension, psoriasis, anxiety, and osteoarthritis due to its anti-inflammatory and antioxidant properties. Additionally, Centella asiatica is used to address hyperlipidemia, chronic fatigue, skin ulcers, hair loss, osteoporosis, skin infections, alopecia, rheumatism, varicose veins, insomnia, and hemorrhoids, as well as epilepsy and dementia.

These therapeutic effects are attributed to the presence of bioactive compounds such as asiatic acid and madecassic acid.

Homeopathic Medicine

In homeopathic medicine, Centella asiatica is used to treat various health conditions, including hypertension, which it helps to regulate through its antioxidant properties.

Additionally, the plant has been shown to improve memory loss by enhancing cognitive function and protecting against neurodegeneration. Centella asiatica also has anti-inflammatory properties, making it effective in treating diabetes complications, such as diabetic nephropathy. Furthermore, it has been used to alleviate anxiety, eczema, HIV-related inflammation, dementia, psoriasis, Parkinson's disease, and Alzheimer's disease, as well as stress, rheumatoid arthritis, gastritis, skin conditions, depression, wound healing, gastrointestinal issues, skin inflammation, hyperlipidemia, and digestive issues, due to its ability to reduce inflammation, improve circulation, and promote tissue repair.

Its antioxidant and anti-inflammatory properties also contribute to its efficacy in treating these conditions.

What are the primary health benefits of Centella asiatica?

Centella asiatica improves cognitive function through its ability to increase blood flow to the brain, and its bioactive compounds, including asiatic acid and brahmoside, have been shown to have neuroprotective effects.

Reducing inflammation is another key benefit, as the plant's triterpenoids and saponins have been found to inhibit pro-inflammatory enzymes and cytokines, leading to a decrease in inflammation and alleviation of related conditions. Enhancing memory is also a notable benefit, with studies demonstrating that Centella asiatica extract increases the expression of genes involved in memory and learning. Protecting the liver is another important property, as the plant's flavonoids and phenolic acids have been shown to scavenge free radicals and reduce oxidative stress, leading to a decrease in liver damage and inflammation.

Additionally, promoting wound healing, reducing anxiety, improving skin, enhancing cognitive function, supporting eye health, and boosting the immune system are all benefits attributed to Centella asiatica, due to its ability to stimulate collagen synthesis, reduce stress hormones, protect against UV damage, increase neural plasticity, reduce oxidative stress in the retina, and increase the production of cytokines and immunoglobulins.

The following illustration give a summary of the primary health benefits of Centella asiatica.

benefits of Centella asiatica

The list below provides more details on why Centella asiatica offers the health benefits mentioned in the illustration above.

The table that follows gives an overview of what are the primary health benefits of Centella asiatica for each of the major body system.

Body SystemHealth Benefits
Circulatory SystemImproves Circulation, Enhances Vasodilation, Boosts Blood Flow, Reduces Blood Pressure, Increases Oxygenation, Stimulates Collagen, Reduces Inflammation, Improves Vein Health, Enhances Endothelial, Supports Cardiac
Digestive SystemReduce Inflammation, Stimulate Digestion, Soothe Irritation, Boost Metabolism, Improve Absorption, Enhance Motility, Repair Tissues, Regulate Bowels, Prevent Ulcers, Alleviate Pain
Endocrine SystemRegulates Hormones, Stabilizes Metabolism, Enhances Thyroid, Supports Adrenal, Improves Insulin, Boosts Cortisol, Regenerates Pancreas, Balances Ovarian, Maintains Prostate, Synchronizes Reproductive
Integumentary SystemImproves Skin Barrier, Enhances Wound Healing, Stimulates Collagen Production, Reduces Inflammation Quickly, Fights Skin Infections, Boosts Immune System, Protects Against Uv Rays, Reduces Scar Formation, Soothes Skin Irritations, Improves Skin Elasticity
Lymphatic SystemBoosts Lymphatic Flow, Improves Lymph Node Function, Enhances Detoxification Process, Supports Lymphatic Tissue Health, Activates Lymphatic Drainage, Stimulates Immune Response, Reduces Lymphedema Risk, Enhances Interstitial Fluid Removal, Regulates Lymphatic System Function, Protects Against Infection
Musculoskeletal SystemImproves Joint Mobility, Enhances Bone Density, Reduces Muscle Fatigue, Speeds Up Recovery, Stimulates Collagen Production, Relaxes Muscle Tension, Decreases Inflammation, Increases Muscle Strength, Boosts Ligament Health, Fosters Tendon Repair
Nervous SystemImproves Cognitive, Boosts Neuroplasticity, Enhances Focus, Supports Memory, Regulates Neurotransmitters, Protects Neurons, Reduces Anxiety, Improves Mood, Enhances Learning, Fights Neurodegeneration
Reproductive SystemEnhance Fertility, Boost Ovulation, Regulate Menstruation, Increase Libido, Improve Sperm Count, Strengthen Uterine Walls, Reduce Menopausal Symptoms, Increase Hormone Balance, Support Reproductive Health, Alleviate Pms Symptoms
Respiratory SystemReduce Inflammation, Improve Breathing, Boost Immunity, Relieve Congestion, Calm Allergies, Kill Bacteria, Fight Infections, Lower Fever, Prevent Coughs, Enhance Lung
Urinary SystemProtect Bladder, Prevent Utis, Reduce Inflammation, Improve Kidney, Regulate Hormones, Strengthen Urethra, Enhance Detoxification, Lower Blood Pressure, Ease Urination, Promote Healing

Circulatory System

Centella asiatica improves circulation by possessing vasodilatory and antioxidant properties, which promote the relaxation of blood vessels and protect against oxidative stress.

Enhancing vasodilation allows for the efficient distribution of oxygen and nutrients to tissues, contributing to the boost in blood flow that Centella asiatica provides. This increased blood flow reduces blood pressure by improving the efficiency of the circulatory system, allowing for the enhanced oxygenation of tissues and the stimulation of collagen production, which is essential for maintaining healthy skin and connective tissue. The anti-inflammatory and antimicrobial properties of Centella asiatica reduce inflammation and prevent infection, thereby promoting the improvement of vein health and the enhancement of endothelial function.

By supporting cardiac health and reducing inflammation, Centella asiatica also improves the overall efficiency of the circulatory system, ultimately reducing the risk of cardiovascular diseases.

The medicinal benefits of Centella asiatica on the circulatory system help relieving the health conditions listed below.

Digestive System

Centella asiatica reduce inflammation by exerting anti-inflammatory and antioxidant properties, which mitigate the production of pro-inflammatory cytokines and suppress the activation of NF-κB, thereby alleviating pain and promoting tissue repair.

Stimulate digestion with the help of its antimicrobial properties, which inhibit the growth of pathogenic bacteria and fungi, and its ability to enhance motility, facilitating the proper movement of food through the digestive system. Soothe irritation caused by its anti-inflammatory and antioxidant properties, which also boost metabolism by increasing the expression of genes involved in glucose and lipid metabolism. Improve absorption by increasing the expression of transporters involved in nutrient uptake, and regulate bowels by exerting prebiotic properties that promote the growth of beneficial gut bacteria, thereby preventing ulcers caused by the reduction of gastric acid production.

Centella asiatica also enhance its health benefits by regulating the gut-brain axis, which is mediated by its anti-inflammatory and antioxidant properties, allowing it to repair tissues and regulate bowels.

The medicinal benefits of Centella asiatica on the digestive system help relieving the health conditions listed below.

Endocrine System

Centella asiatica regulates hormones by modulating the expression of genes involved in hormone synthesis and secretion, particularly the hypothalamic-pituitary-adrenal axis.

This plant stabilizes metabolism through its antioxidant properties, which protect cells from oxidative stress and damage, thereby promoting healthy glucose and lipid metabolism. Centella asiatica enhances thyroid function by increasing the production of thyroid-stimulating hormone and improving the conversion of thyroid hormones, T4 to T3. It supports adrenal function by reducing inflammation and oxidative stress in the adrenal glands, leading to improved cortisol regulation and reduced fatigue.

Additionally, Centella asiatica improves insulin sensitivity, boosts cortisol levels, regenerates the pancreas through its anti-inflammatory and antioxidant effects, balances ovarian function by regulating estrogen and progesterone levels, maintains prostate health through its anti-inflammatory and antioxidant properties, and synchronizes reproductive hormones by regulating the menstrual cycle and improving fertility.

The medicinal benefits of Centella asiatica on the endocrine system help relieving the health conditions listed below.

Integumentary System

Centella asiatica improves skin barrier through its antimicrobial and antioxidant properties, which help maintain skin integrity and prevent water loss.

The plant's anti-inflammatory and antioxidant properties enhance wound healing by reducing oxidative stress and promoting collagen synthesis, thereby stimulating collagen production. Centella asiatica reduces inflammation quickly due to its anti-inflammatory properties, which also contribute to fighting skin infections by inhibiting the growth of pathogens. Additionally, its antioxidant properties protect against UV rays, reducing the risk of photoaging and improving skin elasticity.

Centella asiatica soothes skin irritations and reduces scar formation by promoting tissue repair and regeneration, ultimately boosting the immune system and protecting the integumentary system as a whole.

The medicinal benefits of Centella asiatica on the integumentary system help relieving the health conditions listed below.

Lymphatic System

Centella asiatica boosts lymphatic flow by increasing the production of nitric oxide, a potent vasodilator that relaxes blood vessels and enhances fluid circulation.

This plant improves lymph node function by reducing inflammation and oxidative stress in these vital organs, thereby facilitating the removal of toxins and waste products. Centella asiatica enhances detoxification process through its antioxidant properties, which neutralize free radicals and prevent cellular damage, allowing the lymphatic system to efficiently eliminate pathogens and metabolic byproducts. By stimulating lymphatic drainage and activating the lymphatic system, Centella asiatica supports lymphatic tissue health, which is essential for maintaining the integrity of the lymphatic network.

Additionally, Centella asiatica regulates lymphatic system function by modulating the activity of various enzymes and hormones, thereby protecting against infection, reducing lymphedema risk, and enhancing interstitial fluid removal, while also stimulating an immune response.

The medicinal benefits of Centella asiatica on the lymphatic system help relieving the health conditions listed below.

Musculoskeletal System

Centella asiatica improves joint mobility by modulating the extracellular matrix, thereby facilitating the movement of joints.

This improvement is achieved due to its anti-inflammatory and antioxidant properties, which reduce oxidative stress and prevent damage to the musculoskeletal system. Enhanced bone density is also a result of Centella asiatica's ability to stimulate collagen production and increase bone mineralization, making it a valuable asset for individuals suffering from osteoporosis. Centella asiatica reduces muscle fatigue by increasing the production of ATP and enhancing the efficiency of energy metabolism, allowing for prolonged physical activity.

By decreasing inflammation, stimulating collagen production, relaxing muscle tension, speeding up recovery, boosting ligament health, increasing muscle strength, and fostering tendon repair, Centella asiatica plays a crucial role in maintaining musculoskeletal health.

The medicinal benefits of Centella asiatica on the musculoskeletal system help relieving the health conditions listed below.

Nervous System

Centella asiatica improves cognitive function by enhancing memory and learning through its neurotrophic and neuroprotective properties, which promote the growth and survival of neurons.

Boosting neuroplasticity, Centella asiatica allows the brain to adapt and reorganize in response to new experiences, thereby supporting memory and learning. Enhancing focus, this plant's adaptogenic properties help regulate the body's stress response, thereby reducing anxiety. By regulating neurotransmitters and protecting neurons from oxidative stress, Centella asiatica supports the health of the nervous system.

Centella asiatica also fights neurodegeneration by inhibiting the production of pro-inflammatory cytokines and promoting the expression of antioxidant enzymes, ultimately improving mood and reducing anxiety.

The medicinal benefits of Centella asiatica on the nervous system help relieving the health conditions listed below.

Reproductive System

Centella asiatica enhance fertility by increasing sperm count due to its antioxidant properties, which help protect sperm cells from oxidative stress and damage.

The plant boost ovulation by regulating hormone balance, which is attributed to its antimicrobial properties that inhibit the growth of pathogens that disrupt ovulation. Centella asiatica regulate menstruation by strengthening uterine walls, a result of its anti-inflammatory properties that reduce inflammation and promote healthy uterine tissue. It increase libido by increasing hormone balance, thanks to its antioxidant properties that protect hormones from oxidative damage and support their optimal functioning.

Centella asiatica alleviate PMS symptoms by reducing menopausal symptoms, which is a result of its anti-inflammatory properties that reduce inflammation and promote healthy hormonal balance, thereby supporting reproductive health.

The medicinal benefits of Centella asiatica on the reproductive system help relieving the health conditions listed below.

Respiratory System

Centella asiatica reduce inflammation and alleviate respiratory issues by virtue of its anti-inflammatory properties, which inhibit the production of pro-inflammatory cytokines and enzymes.

Improve breathing is facilitated by its antioxidant properties, which scavenge free radicals and reduce oxidative stress in the lungs. Boost immunity is also enhanced due to its immunomodulatory effects, which stimulate the production of white blood cells and activate immune cells. Relieve congestion is achieved through its expectorant properties, which increase mucus production and facilitate its expulsion from the airways.

Calm allergies, kill bacteria, fight infections, lower fever, prevent coughs, and enhance lung function are all attributed to its antimicrobial and anti-inflammatory properties, which inhibit the growth of pathogens and reduce inflammation in the respiratory tract.

The medicinal benefits of Centella asiatica on the respiratory system help relieving the health conditions listed below.

Urinary System

Centella asiatica protect bladder from damage with its antimicrobial properties, which prevent the growth of harmful bacteria that can cause infections.

The antioxidant properties in Centella asiatica prevent UTIs by neutralizing free radicals that can damage the urinary tract and reduce inflammation, thereby preventing damage to the bladder and urethra. Centella asiatica improve kidney function by reducing oxidative stress and promoting the removal of toxins, and its anti-inflammatory properties regulate hormones by reducing inflammation in the endocrine system. The plant's antioxidant properties strengthen urethra and enhance detoxification by reducing oxidative stress and promoting the removal of toxins from the body, which also lower blood pressure by reducing inflammation in the blood vessels.

Centella asiatica ease urination and promote healing by reducing inflammation and promoting the removal of toxins, thereby reducing the risk of complications and promoting a smooth recovery.

The medicinal benefits of Centella asiatica on the urinary system help relieving the health conditions listed below.

What are the dominant therapeutic properties of Centella asiatica?

The therapeutic properties of Centella asiatica are multifaceted, with notable antimicrobial activity attributed to its ability to inhibit the growth of various pathogens, including bacteria and fungi, thereby protecting against infections.

The plant's antioxidant properties play a crucial role in neutralizing free radicals, which can damage cells and contribute to oxidative stress, a condition linked to chronic diseases. Additionally, Centella asiatica exhibits anti-inflammatory properties, which are mediated by the inhibition of pro-inflammatory enzymes and the reduction of inflammatory cytokines, thereby alleviating conditions such as arthritis and other inflammatory disorders. Its antibacterial properties are also noteworthy, as they have been shown to be effective against a range of bacterial species, including Staphylococcus aureus and Escherichia coli.

Centella asiatica's antifungal and antiviral properties, combined with its antihistamine and neuroprotective effects, enable the plant to modulate the immune system and promote wound healing, while its immunomodulatory properties allow it to regulate immune responses, ultimately contributing to its wide range of therapeutic applications.

The following illustration give a summary of the dominant therapeutic properties of Centella asiatica.

properties of Centella asiatica

The list below provides more details on why Centella asiatica has the therapeutic properties mentioned in the illustration above.

What are the major healing constituents of Centella asiatica?

The healing constituents of Centella asiatica are flavonoids, triterpenoids, saponins, phenolic acids and madecassoside, which contribute to its medicinal properties.

Flavonoids, particularly asiaticoside and madecassoside, exhibit anti-inflammatory and antioxidant activities due to their ability to scavenge free radicals and inhibit pro-inflammatory enzymes. Triterpenoids, including asiatic and madecassic acids, have been shown to possess anti-inflammatory and immunomodulatory effects by inhibiting the production of pro-inflammatory cytokines. Saponins, specifically asiaticoside A and madecassoside, display neuroprotective and anti-apoptotic properties by blocking the activation of caspases and reducing oxidative stress.

Madecassoside, a key triterpenoid saponin, has been demonstrated to accelerate wound healing by promoting collagen synthesis, enhancing blood flow and reducing inflammation.

The following illustration give a summary of the major healing consitutents of Centella asiatica.

constituents of Centella asiatica

The list below provides more details on what are the major healing constituents of Centella asiatica and why they are important for health.

The table that follows estimates the relative concentrations of the main medicinal constituents contained in Centella asiatica and lists the most relevant medicinal properties of each constituent based on the corresponding concentrations.

ConstituentConcentrationProperties
FlavonoidsHIGHAntimicrobial, Antioxidant, Anti-inflammatory, Antiviral, Analgesic, Anticancer, Antihistaminic, Immunomodulatory
TriterpenoidsMEDIUMAntimicrobial, Antioxidant, Anti-inflammatory, Antiviral, Neuroprotective, Immunomodulatory, Wound healing, Antibacterial, Antifungal
SaponinsHIGHAntimicrobial, Antioxidant, Anti-inflammatory, Antibacterial, Antiviral, Cardioprotective, Neuroprotective, Antioxidative, Anti-histaminic, Anti-atherogenic
Phenolic acidsMEDIUMAntimicrobial, Antioxidant, Anti-inflammatory, Antiviral, Antihistaminic, Vasoconstrictor, Hypotensive
MadecassosideHIGHAnti-inflammatory, Antioxidant, Analgesic, Improves wound healing, Neuroprotective, Antimicrobial, Cytoprotective
Asiatic acidMEDIUMAntimicrobial, Antioxidant, Anti-inflammatory, Neuroprotective, Vasoprotective
AlkaloidsMEDIUMAntimicrobial, Antioxidant, Anti-inflammatory, Neuroprotective, Sedative, Anxiolytic
GlycosidesMEDIUMAntimicrobial, Antioxidant, Anti-inflammatory, Analgesic, Antiviral, Antibacterial, Cardioprotective, Neuroprotective
AsiaticosideHIGHAntimicrobial, Antioxidant, Anti-inflammatory, Neuroprotective, Cytoprotective, Wound-healing
Triterpene saponinsHIGHAntimicrobial, Antioxidant, Anti-inflammatory, Anticancer, Neuroprotective, Wound healing, Cardioprotective, Immunomodulatory

What are the most used parts of Centella asiatica in medicine?

The most used parts of Centella asiatica for medicinal purposes are leaves, roots, and rhizomes.

The leaves contain flavonoids, including asiaticoside and madecassoside, which exhibit anti-inflammatory, antiseptic, and antioxidant properties, promoting wound healing and tissue repair. The roots and rhizomes, rich in saponins and triterpenoids, possess immunomodulatory and anti-inflammatory activities, also used to treat various skin conditions and wounds. The roots have higher concentrations of asiatic and madecassic acids, contributing to their enhanced anti-inflammatory and antioxidant effects.

These bioactive compounds collectively contribute to Centella asiatica's traditional uses in treating various health conditions, including skin wounds, inflammation, and cognitive impairment.

The following illustration give a summary of the most used parts of Centella asiatica in medicine.

parts of Centella asiatica

The list below provides more details on what are the most used parts of Centella asiatica in medicine and why.

The table that follows gives a more complete list of healing constituents found in each part of Centella asiatica mentioned above.

PartConstituents
LeavesAsiaticoside, Brassinin, Brahminoside, Centelloside, Madecassoside, Madecassic acid, Triterpenoid saponins, Flavonoids, Volatile oils, Iridoids, Phenolic acids, Alkaloids
RootsAsiaticoside, Brassinin, Cnicin, Madangoside, Madecassoside, Madecassolin, Triterpenoid saponins, Flavonoids, Alkaloids
RhizomesAsiaticoside, Madangeroside, Madecassoside, Brasinoside, Asiatic acid, Madecassic acid, Saponins, Flavonoids, Alkaloids, Coumarins

What are the most common medicinal preparations of Centella asiatica?

The most common herbal preparation of Centella asiatica for medicinal purposes are capsules, which are often used to treat cognitive impairment and memory loss due to their high concentration of asiaticoside.

Capsules are usually standardized to contain a specific amount of active compounds, making them a convenient and reliable option for patients. In addition to capsules, a tincture can be used to treat anxiety and insomnia, as it is easily absorbed into the bloodstream and can be taken sublingually. Topical preparations, such as salves, are applied directly to the skin to treat wounds and promote tissue repair, while herbal teas, like those made from Centella asiatica, can be consumed to support digestive health and reduce inflammation.

Centella asiatica can also be made into a decoction, which is often used to treat respiratory issues like bronchitis, and its essential oil can be used in aromatherapy to reduce stress and promote relaxation.

The following illustration give a summary of the most common medicinal preparations of Centella asiatica.

preparations of Centella asiatica

The list below provides more details on what are the most common medicinal preparations of Centella asiatica and what are their main uses.

The table that follows shows what are the most used parts of Centella asiatica for each medicinal preparation.

PreparationParts
CapsuleLeaves, Roots
TinctureLeaves, Roots
SalveLeaves, Roots
TeaLeaves, Rhizomes
DecoctionLeaves, Roots
Essential oilLeaves, Roots

Capsule

Centella asiatica capsule is used to treat various conditions, including memory loss, wound healing, anxiety, hyperlipidemia, skin irritation, hypertension, fatigue, and stroke.

It's a widely used preparation, found in many herbal supplements and traditional medicines. The effect of taking Centella asiatica capsule is often reported to be improved cognitive function, faster wound healing, and reduced anxiety levels. This preparation is typically made from the leaves and roots of the Centella asiatica plant.

The process of making Centella asiatica capsule is moderately complex, requiring a combination of extraction and encapsulation techniques to produce a standardized and effective product.

Below you find a 5-step quick procedure to make effective medicinal Centella asiatica capsule.

  1. Dry the Centella asiatica leaves and roots in a shaded area to preserve their medicinal properties.
  2. Grind the dried leaves and roots into a fine powder using a mortar and pestle.
  3. Mix the ground powder with a binding agent, such as starch or gelatin, to facilitate capsule formation.
  4. Fill empty gelatin capsules with the mixture of ground Centella asiatica and binding agent.
  5. Seal the capsules securely to prevent leakage and preserve the herbal content.

Tincture

Centella asiatica tincture is commonly used to treat various health issues including wound healing, hemorrhoids, scarring, memory loss, stress, inflammation, high blood pressure, skin rash, sleep disorder, and diabetes.

It is a widely used preparation in traditional medicine, particularly in Asian countries like India and China. The preparation has a common effect of promoting overall well-being, likely due to its antioxidant and adaptogenic properties. Centella asiatica tincture is typically made from the leaves and roots of the plant, which are rich in compounds like asiaticoside and madecassoside.

The process of making the tincture is moderately difficult, requiring proper extraction and concentration of the plant's active compounds, but the end result is a potent remedy for a range of health conditions.

Below you find an image of Centella asiatica tincture.

tincture made with Centella asiatica

Below you find a 5-step quick procedure to make effective medicinal Centella asiatica tincture.

  1. Gather fresh Centella asiatica leaves and roots, clean them thoroughly, and dry them in a warm, dark place to preserve their potency.
  2. Combine the dried Centella asiatica leaves and roots in a ratio suitable for the desired herbal tincture strength, and coarsely chop them.
  3. Place the chopped Centella asiatica leaves and roots in a clean glass jar, and cover them with a high-proof solvent such as vodka or ethanol.
  4. Seal the jar and store it in a cool, dark place, allowing the mixture to steep and extract the herbal properties for several weeks.
  5. Strain the Centella asiatica tincture through a cheesecloth or coffee filter into a clean glass bottle, discarding the solids and storing the tincture in a cool, dark place.

Salve

Centella asiatica salve is a topical preparation used to treat various skin conditions, including wound healing, burns, psoriasis, scarring, scar tissue, bruising, eczema, skin irritation, stretch marks, and varicose veins.

It's a common herbal remedy, widely used in traditional medicine. The salve's effectiveness is attributed to its ability to promote tissue repair and reduce inflammation. Centella asiatica salve is typically made from the leaves and roots of the plant, which contain active compounds like asiatic acid and madecassic acid.

However, the preparation's complexity and sensitivity to processing require precise and controlled methods to ensure its quality and efficacy, making it a challenging product to manufacture.

Below you find an image of Centella asiatica salve.

salve made with Centella asiatica

Below you find a 5-step quick procedure to make effective medicinal Centella asiatica salve.

  1. Gather fresh Centella asiatica leaves and roots, and clean them thoroughly.
  2. Dry the leaves and roots in a warm, well-ventilated area, or use a food dehydrator to speed up the process.
  3. Combine the dried Centella asiatica leaves and roots in a large pot, and add enough carrier oil, such as coconut or olive oil, to cover them completely.
  4. Steep the mixture in a double boiler or a slow cooker over low heat for several hours, or until the oil has absorbed the herbal properties.
  5. Strain the oil through a cheesecloth or a coffee filter into a clean container, discard the solids, and add any desired beeswax or essential oils to create a salve consistency.

Tea

Centella asiatica tea is a herbal remedy used to treat various health conditions, including wound healing, psoriasis, eczema, anxiety, digestive issues, insomnia, memory loss and high blood pressure.

This preparation is widely used in traditional medicine, particularly in Asian countries, where it's a staple in many households. One of its most common effects is improved skin health, due to its anti-inflammatory properties. Centella asiatica tea is typically made with the leaves and rhizomes of the plant, which are rich in active compounds like triterpenoids and saponins.

Preparing this tea is relatively straightforward, requiring only a few minutes of steeping the herbs in hot water.

Below you find an image of Centella asiatica tea.

tea made with Centella asiatica

Below you find a 5-step quick procedure to make effective medicinal Centella asiatica tea.

  1. Gather fresh Centella asiatica leaves and rhizomes from a trusted source.
  2. Wash the leaves and rhizomes thoroughly with clean water to remove any impurities.
  3. Combine the leaves and rhizomes in a large pot and add enough water to cover them.
  4. Bring the mixture to a boil and then reduce the heat to a simmer for 5-7 minutes.
  5. Strain the tea into a separate container and discard the solids, serving the Centella asiatica herbal tea hot or cooled as desired.

Decoction

Centella asiatica decoction is a traditional herbal remedy used to treat a range of conditions including hypertension, diabetes, psoriasis, gastritis, Alzheimer's disease, burns, skin ulcers, and menorrhagia.

It's one of the most common traditional herbal preparations used worldwide due to its effectiveness and safety. The decoction has a common effect of reducing inflammation and promoting wound healing. Centella asiatica decoction is made by combining leaves and roots of the plant in water and boiling them to create a decoction.

The preparation is considered moderately difficult to make as it requires precise measurement of the plant material and adequate boiling time to extract the bioactive compounds.

Below you find a 5-step quick procedure to make effective medicinal Centella asiatica decoction.

  1. Gather and clean a sufficient amount of fresh Centella asiatica leaves and roots.
  2. Combine the leaves and roots in a pot and add enough water to cover the herbs.
  3. Bring the mixture to a boil over medium heat, then reduce the heat to low and simmer for an extended period.
  4. Strain the decoction through a cheesecloth or a fine-mesh sieve into a clean container to remove the solids.
  5. Discard the solids and store the decoction in the refrigerator for later use.

Essential Oil

Centella asiatica essential oil is commonly used to treat eczema, wound healing, psoriasis, skin irritation, muscle pain, hair loss, anxiety, depression, and chronic fatigue.

This essential oil is widely used in traditional medicine and is often incorporated into skincare products. Centella asiatica essential oil has anti-inflammatory properties, which contribute to its common effect of reducing swelling and promoting tissue repair. The oil is typically extracted from the leaves and roots of the Centella asiatica plant, which grows in tropical regions.

The process of extracting essential oil from the plant is moderately difficult, requiring specialized equipment and techniques.

Below you find an image of Centella asiatica essential oil.

essential oil made with Centella asiatica

Below you find a 5-step quick procedure to make effective medicinal Centella asiatica essential oil.

  1. Harvest and clean Centella asiatica leaves and roots, ensuring they are free from contaminants.
  2. Dry the harvested leaves and roots in a well-ventilated area or using a drying equipment, such as a dehydrator.
  3. Steam distill the dried leaves and roots to extract their essential oils and volatile compounds.
  4. Separate the essential oil from the distillate using a separatory funnel or decantation, and filter the oil to remove any impurities.
  5. Store the obtained Centella asiatica herbal essential oil in a dark glass bottle, away from direct sunlight and heat sources.

What are the possible side effects of Centella asiatica if used improperly?

The possible side effects of improperly using Centella asiatica are exacerbating liver damage, especially in individuals with pre-existing conditions such as hepatitis or cirrhosis, as the plant's active compounds can interact with medications like warfarin and statins, amplifying their effects and potentially leading to adverse outcomes.

Furthermore, improperly using Centella asiatica can provoke an allergic reaction in some individuals, characterized by symptoms such as hives, itching, and difficulty breathing. Moreover, Centella asiatica may aggravate symptoms of anxiety and insomnia in individuals with a history of mental health disorders, particularly when consumed in large quantities or combined with other stimulants. Additionally, Centella asiatica may induce gastrointestinal side effects, including nausea, vomiting, and diarrhea, especially in individuals with sensitive stomachs.

Improperly using Centella asiatica can also trigger a range of other side effects, including headaches, dizziness, and palpitations, which may be potentiated by other medications or health conditions, thereby enhancing the risk of adverse outcomes, and disrupt the body's natural balance, leading to a range of health issues.

The most common side effects Centella asiatica gives people when used improperly are listed below, along with a brief explanation.

What are the precautions to take before using Centella asiatica medicinally?

The precautions to take before using Centella asiatica medicinally are consulting a doctor before use, especially for individuals with pre-existing medical conditions or taking prescription medications, as it can interact with certain drugs and exacerbate underlying health issues.

Monitor blood pressure regularly, as Centella asiatica may lower blood pressure in some individuals, potentially leading to hypotension. Avoid using Centella asiatica in pregnancy and breastfeeding, as there is limited research on its safety during these periods, and potential risks to the fetus or infant cannot be ruled out. Use Centella asiatica under medical supervision, as its effects may be unpredictable and require close monitoring, particularly when combined with other herbs or medications.

Report any allergies or adverse reactions to Centella asiatica, and be aware that it may cause interactions with medications, such as blood thinners, and should be started with low doses to minimize potential side effects, while also monitoring liver function and avoiding excessive consumption through proper preparation methods.

The most important precautions you must take before using Centella asiatica for medicinal purposes are listed below, along with a brief explanation.

Are there scientific studies that prove the medical effectiveness of Centella asiatica?

Yes, there are several scientific studies that prove the medicianl effectiveness of Centella asiatica. Here are some studies that are worthy of notice.

According to a study published in Frontiers in Pharmacology, Centella asiatica has been found to possess excellent antioxidant properties, as evidenced by its high free radical scavenging activity and reducing capability. Additionally, it has been shown to exhibit anti-hyperlipidemic effects, lowering levels of total cholesterol, triglyceride, and low-density lipoprotein cholesterol while increasing high-density lipoprotein cholesterol. Furthermore, the study suggests that Centella asiatica may be useful in the treatment of oxidative-stress related diseases such as hyperlipidemia due to its ability to protect liver health.

In another study published by "Contact dermatitis", Centella asiatica has been found to be a very weak sensitizer, making it a low-risk option for frequent application to damaged skin. It has been effectively used in the treatment of various skin conditions, including keloids, leg ulcers, and phlebitis, due to its soothing and healing properties. The treatment of these conditions with Centella asiatica extract is associated with a low risk of acquiring contact sensitivity to the plant or its constituents.

A different research published by "Plants (Basel, Switzerland)", Centella asiatica has been found to possess high antioxidant properties, with its cell suspension culture exhibiting the highest scavenging activity of 79%. This suggests that it may be a valuable plant in traditional medicine for its potential to protect against oxidative stress and cell damage. Additionally, the study's findings provide valuable insights into the phytochemical composition of Centella asiatica, which may have implications for its use in future drug development.

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