Celastrus flagellaris
Celastrus flagellaris · Accepted scientific name
Scientific literature: Very Sparse (1 studies) · ★☆☆☆☆
Celastrus flagellaris is a botanical species that has garnered significant scientific interest due to its unique chemical profile. Researchers are increasingly focusing on this plant because of its potent neuroprotective activities. These biological properties suggest that the plant may play a vital role in defending the nervous system against oxidative stress and degeneration. By studying its molecular mechanisms, scientists hope to uncover new pathways for treating neurological disorders. Consequently, this species stands as a promising subject in the ongoing search for natural therapeutic agents.
- Synonyms
- Celastrus Ciliidens · Celastrus Clemacanthus
- Common names
- Not available
- Family
- Celastraceae
- Distribution
- Not available
- Plant Parts
- Not available
Classification
Common Names
Celastrus flagellaris is a unique climbing plant known by a diverse array of regional names across different languages. In Slovak, it is commonly referred to as bršlenec šľahúňovitý, while in Polish, it carries the name dławisz ciernisty. The species is also identified in Tamil as kynsikelasköynnös, highlighting its global presence. Moving into Slavic linguistic variations, it is recognized as both Древогубец плетевидный and Древогубец плетеобразный. These varied common names reflect the plant's widespread distribution and cultural significance in various parts of the world.
Sources: Catalogue of Life (COL)
Synonyms
Celastrus flagellaris is a botanical species that has historically been identified through several different scientific names. Within taxonomic records, it is recognized as having the synonym Celastrus ciliidens. Furthermore, researchers have also documented the plant under the synonym Celastrus clemacanthus. These overlapping designations reflect the evolving nature of botanical classification and nomenclature. Understanding these relationships is essential for ensuring accuracy in plant identification and scientific study.
Sources: The World Checklist of Vascular Plants (WCVP)
Taxonomy
Celastrus flagellaris is a specialized organism belonging to the vast kingdom Plantae. Within this kingdom, it is classified under the class Equisetopsida. The plant further belongs to the order Celastrales, which helps define its evolutionary lineage. It is a member of the family Celastraceae, a group known for its distinct botanical characteristics. Ultimately, this species is identified by its placement within the genus Celastrus.
| Rank | Classification |
|---|---|
| Kingdom | Plantae |
| Phylum | Streptophyta |
| Class | Equisetopsida |
| Subclass | Magnoliidae |
| Order | Celastrales |
| Family | Celastraceae |
| Genus | Celastrus |
Sources: The World Checklist of Vascular Plants (WCVP)
Distribution
Geographic Regions
Celastrus flagellaris is a resilient species with a broad geographic reach across the Asia-Temperate region. Its native range extends through various parts of China, including the North-Central and Manchuria territories. The plant is also well-established in Eastern Asia, appearing frequently throughout Japan and Korea. Furthermore, its presence can be traced to the Russian Far East, specifically within the Primorye region. This wide distribution highlights the plant's ability to thrive in diverse temperate environments across the continent.
Sources: The World Checklist of Vascular Plants (WCVP)
Identification
Morphology
Celastrus flagellaris is a self-supporting shrub that establishes a sturdy presence within its natural habitat. This plant typically grows to a minimum height of 1 meter, allowing it to occupy various layers of the vegetation. Depending on its environment, it can reach a maximum height of up to 10 meters. This versatile growth form makes it a notable component of its local ecosystem.
Sources: Global Inventory of Floras and Traits (GIFT)
Biological Activities
Celastrus flagellaris serves as a significant source of natural β-dihydroagarofuran-type sesquiterpenoids that demonstrate promising therapeutic potential. Research indicates that these specific compounds possess notable neuroprotective activity, particularly in combating the cellular damage associated with neurodegenerative disorders. In experimental models, these sesquiterpenoids successfully rescued SH-SY5Y cells from viability reduction caused by amyloid-beta toxicity. Furthermore, the study highlighted their ability to attenuate cognitive impairments, such as prolonged escape latency, in subjects. These findings suggest that the chemical skeletons found within this plant could serve as essential drug leads for developing new treatments against Alzheimer's disease.
Compounds
Conditions
Celastrus flagellaris contains natural β-dihydroagarofuran-type sesquiterpenoids that function as potential cognition-enhancing and neuroprotective agents against Alzheimer's disease. Specific compounds identified from this plant, such as sesquiterpenoids 58, 59, 61, and 63, significantly attenuated cognitive impairments like prolonged escape latency. Furthermore, 21 of the tested sesquiterpenoids successfully rescued SH-SY5Y cells from viability reduction induced by Aβ25-35. The study highlights that those containing ester groups exhibited stronger therapeutic activity than those without such substituents. Consequently, these chemical structures serve as promising drug leads for developing novel therapeutic agents to treat Alzheimer's disease.