Catha edulis

What's the taxonomical classification of Catha edulis?

Catha eduledis belongs to the kingdom Plantae and is classified under the phylum Streptophyta. Within this lineage, it is situated in the class Equisetopsida and the subclass Magnoliidae. The taxonomic hierarchy continues through the order Celastrales and the family Celastraceae. Finally, the plant is identified by its specific genus, Catha, and its unique species designation, eduledis.

Taxonomic Rank Classification
Kingdom Plantae
Phylum Streptophyta
Class Equisetopsida
Subclass Magnoliidae
Order Celastrales
Family Celastraceae
Genus Catha
Species edulis
Evidence Level: ★★★★☆

What are the morphological characteristics of this plant?

Catha edulis has an erect, woody shrub structure that typically reaches heights of one to three meters and features slender, branching stems with a rough texture. The leaves are small, ovate to elliptical in shape, and arranged in an opposite or sub-opposite pattern along the branches. These leaves possess acute tips and finely serrated margins, often appearing a deep green color when mature. The plant produces small, inconspicuous white or greenish flowers that emerge from the axils of the leaves. Its root system is fibrous and well-developed to support its growth in various highland environments.

Evidence Level: ★☆☆☆☆

What is the geographical distribution of this plant?

This plant is native to the tropical regions of the Horn of Africa and the Arabian Peninsula, specifically spanning Ethiopia, Somalia, Djibouti, Eritrea, and parts of Yemen. It thrives primarily in the highlands and mountainous areas where the climate remains consistently warm and humid. The species is often found growing in the understory of dense forests or along the edges of river valleys. Because it requires high rainfall and specific elevations, its range is restricted to these particular ecological niches. This limited distribution makes it a characteristic feature of the local flora in these arid yet seasonally lush landscapes.

Evidence Level: ★☆☆☆☆

What parts of this plant are used medicinally?

Catha edulis contains psychoactive alkaloids primarily concentrated in its fresh green leaves and young stems. These aerial parts are harvested and consumed to exploit their stimulant properties for various traditional medicinal purposes. The leaves are often chewed or steeped into tea to provide relief from fatigue and improve mental alertness. Some traditional practices also utilize the plant's bark in decoctions to treat specific ailments. Careful management of these plant parts is essential because the chemical potency varies significantly depending on the age of the foliage.

Evidence Level: ★☆☆☆☆

What are the pharmacological activities of Catha edulis?

This plant has pharmacological activities including central stimulant, psychostimulating, stimulant, appetite suppressant, and sympathomimetic effects. These properties are primarily attributed to the presence of alkaloids that influence the nervous system. By acting as a central stimulant, the plant increases alertness and mental focus in the user. Its psychostimulating nature can alter mood and perception, while the sympathomimetic action mimics the effects of adrenaline on the body. Additionally, the plant functions as an appetite suppressant, which can lead to reduced food intake during consumption.

As discussed in a study, d-norpseudoephedrine acts as a central stimulant present in Catha eduilis. This alkaloid is excreted unchanged in human urine and was detected 30-50 min after the ingestion of synthetic d-norpseudoephedrine. Trace amounts of the drug could still be detected in urine 24 hr later. Approximately 40% of ingested d-norpseudoephedrine was recovered in urine during the first 6 hr.

Evidence Level: ★★★☆☆

What medicinal compounds this plant contains?

This plant contains cathine, cathinoone, d-norpseudoephedrine, and various amphetamine alkaloids. These medicinal compounds function as potent central nervous system stimulants. Cathine is a naturally occurring alkaloid that shares structural similarities with ephedrine. The presence of cathinoone further enhances the stimulant profile of the plant's chemical makeup. Additionally, the inclusion of d-norpseudoephedrine contributes to the complex pharmacological activity found within its tissues.

As discussed in a study, Catha eduledis leaves contain amphetamine alkaloids such as cathine and cathinone. These specific compounds are responsible for psychogenic effects including mind stimulation, euphoria, and the suppression of hunger. During a ritual involving seven volunteers, researchers observed an increase in systolic and diastolic pressure in three patients. The peak pressure for these individuals was observed approximately seven hours after the beginning of the ritual. The three patients who experienced pressure changes were not significantly different from the four unaffected patients regarding age or the duration of use.

Evidence Level: ★★★☆☆

What health problems is this plant used for?

This plant is used for treating loss of appetite and anorexia through its anorectic properties. By suppressing the desire to eat, it can help manage conditions where excessive consumption is a concern. It is also widely recognized for its psychostimulating properties which affect the central nervous system. As a potent stimulant, the plant can increase alertness and energy levels in users. These physiological effects make it a significant subject in studies regarding dietary control and mental stimulation.

Evidence Level: ★★★☆☆

What are the herbal preparations of this plant?

This plant can be prepared as fresh leaf chewing, an infusion, a tincture, or a dried leaf powder. Most commonly, users chew the fresh leaves to experience an immediate stimulant effect from the active alkaloids. For a more diluted form, the leaves can be steeped in hot water to create a medicinal infusion. Concentrated extracts are also produced through a tincture process involving alcohol. Alternatively, the plant can be processed into a dried leaf powder for easy storage and consumption.

The main herbal preparations of this plant are shown in the list below.

  • Fresh leaf chewing
  • Infusion
  • Tincture
  • Dried leaf powder
Evidence Level: ★☆☆☆☆

What side effects this plant can have?

This plant can cause a wide range of adverse reactions including insomnia, anxiety, irritability, agitation, hypertension, tachycardia, nausea, dizziness, headache, psychosis, hallucinations, and confusion. Users may experience significant cardiovascular strain such as elevated blood pressure and an abnormally rapid heart rate. Psychological disturbances are common and can escalate from mild restlessness to severe states of mental disorientation or delirium. Gastrointestinal distress like nausea often accompanies the physical sensations of dizziness and headaches. In extreme cases, the consumption of Catha edulis may trigger profound psychiatric episodes characterized by hallucinations and psychosis.

The main side effects this plant can have are shown in the list below.

  • Insomnia
  • Anxiety
  • Irritability
  • Agitation
  • Hypertension
  • Tachycardia
  • Nausea
  • Dizziness
  • Headache
  • Psychosis
  • Hallucinations
  • Confusion
Evidence Level: ★☆☆☆☆