Sodomís apple milkweed

Calotropis procera · Accepted scientific name

Scientific literature: Very Extensive (463 studies) · ★★★★★

Sodomís apple milkweed, scientifically known as Calotropis procera, is a versatile perennial shrub native to arid regions. Renowned in traditional medicine, its leaves, latex, and roots possess potent antibacterial and anti-inflammatory properties. This resilient plant offers significant therapeutic potential for treating various ailments, ranging from skin conditions to inflammation.

Family
Apocynaceae
Native range
Africa
Parts used
Leaf · Flower
Common names
Apple Of Sodom · Liberty Tree · 17 more
Scientific synonyms
Calotropis Syriaca · Calotropis Inflexa · 9 more

Names and Synonyms

Common Names

Scientific Names

Accepted name

Calotropis procera

Synonyms

Regional and Traditional Names

Spanish:

  • Calotropis persica
  • Calotropis wallichii
  • Madorius procerus
  • Asclepias procera
  • Calotropis inflexa
  • Calotropis syriaca
  • Calotropis busseana
  • Asclepias gigantea
  • Calotropis heterophylla
  • Calotropis hamiltonii
  • tula
  • calotropis
  • Algodoncillo gigante
  • Algodón extranjero
  • Manzano de Sodoma
  • Mudar de la India

German:

  • Oscher
  • Fettblattbaum
  • Mudarpflanze
  • Oscherstrauch
  • Fettblattbaum
  • Judasapfel
  • Oscher

French:

  • Pommier de Sodome
  • Thora thora
  • Torcha
  • Roustonnier
  • arbre à soie
  • calotrope
  • Pommier de Sodome

Sources: Wikidata, Catalogue of Life

Taxonomical Classification

This plant belongs to the kingdom Plantae and is classified under the phylum Streptophyta and the class Equisetopsida. Within the subclass Magnoliidae and the order Gentianaales, it is situated in the family Apocynaceae. Finally, it is identified by its specific genus, Calotropis.

Rank Classification
Kingdom Plantae
Phylum Streptophyta
Class Equisetopsida
Subclass Magnoliidae
Order Gentianales
Family Apocynaceae
Genus Calotropis

Sources: The World Checklist of Vascular Plants (WCVP)

Distribution

This plant is widely distributed across several countries located within the Northern Africa region. It can be found growing naturally in the landscapes of Algeria. Additionally, the species is well-established throughout the territory of Egypt. Its presence extends further west to include the nation of Libya. Finally, this medicinal plant is also commonly documented in both Morocco and Tunisia.

Region Area
Northern Africa Algeria
Northern Africa Egypt
Northern Africa Libya
Northern Africa Morocco
Northern Africa Tunisia
Northern Africa Western Sahara
Macaronesia Canary Is.
Macaronesia Cape Verde
West Tropical Africa Benin
West Tropical Africa Burkina

Sources: The World Checklist of Vascular Plants (WCVP)

Botanical Identification

Ecology

The ecology of Calotropis procera is characterized by its remarkable adaptability to diverse environmental conditions, ranging from sea level up to an elevation of 2720 m AMSL. It thrives in a variety of distinct ecosystems, demonstrating a broad ecological niche that includes anthropogenic areas (Área Antrópica), the semi-arid Caatinga (strict sensu), the tropical savanna of the Cerrado (lato sensu), and the coastal vegetation known as Restinga. This ability to inhabit both disturbed human-influenced landscapes and specialized natural biomes across a wide altitudinal gradient highlights its resilient nature and capacity to colonize varied topographical and climatic settings.

Elevational range max:
2720 m AMSL
Elevational range min:
0 m AMSL
Habitat :
Área Antrópica, Caatinga (stricto sensu), Cerrado (lato sensu), Restinga

Life history

The life history of Calotropis procera is characterized by its classification as a perennial plant, allowing it to persist in its environment over multiple growing seasons. As a phanerophyte, its regenerative buds are located on aerial shoots well above the ground, a structural adaptation that supports its growth habit. Specifically, it functions as both a phanerophyte and a nanophanerophyte, maintaining a woody or semi-woody stature that enables it to endure various environmental conditions throughout its extended lifespan.

Life form :
phanerophyte
Lifecycle :
perennial

Morphology

The morphology of Calotropis procera is characterized by its growth form as a woody shrub that functions as a self-supporting, independent plant. It is a terrestrial species, neither aquatic nor epiphytic, and does not exhibit parasitic behavior. In terms of stature, the plant reaches a minimum height of 1 m, with a mean height of approximately 4 m, and can attain a maximum height of up to 5 m.

Aquatic :
terrestrial
Climber :
self-supporting
Epiphyte :
terrestrial
Growth form :
shrub
Parasite :
independent
Plant height max:
5 m
Plant height mean:
4 m
Plant height min:
1 m
Woodiness :
woody

Physiology

The physiology of Calotropis procera is characterized by specific morphological and metabolic adaptations suited for its environmental niche. The plant utilizes a C3 photosynthetic pathway to facilitate carbon fixation. Its foliage is defined by an opposite leaf arrangement, with individual leaves exhibiting an ovate form. These leaves can reach significant dimensions, with a maximum leaf length of 25 cm and a maximum leaf width of 22 cm. To manage water retention and survive in arid conditions, the plant exhibits succulence. Additionally, Calotropis procera does not function as a nitrogen fixer.

Leaf arrangement :
opposite
Leaf form :
ovate
Leaf length max:
25 cm
Leaf width max:
22 cm
Nitrogen fixer :
no
Photosynthetic pathway :
C3
Succulence :
yes

Reproduction

The reproduction of Calotropis procera is characterized by a biotic pollination syndrome, primarily facilitated by insects. The plant produces inflorescences in the form of an umbel, featuring flowers that exhibit a distinct violet colour. The flowering period typically begins in January and concludes in July, though it can be variable. Reproduction is dependent on cross-pollination, as self-fertilization is absent. Following successful pollination, the plant develops fruit classified as a follicle, with lengths ranging from a minimum of 8 cm to a maximum of 12 cm. The seeds produced within these follicles vary in mass, with a mean weight of 0.010136 g, a minimum of 0.002812 g, and a maximum of 0.023237 g. Once mature, the seeds are distributed via an anemochorous dispersal syndrome, utilizing wind to spread throughout the environment.

Dispersal syndrome :
anemochorous
Flower colour :
violet
Flowering time :
Jan
Flowering time :
Jul
Fruit length max:
12 cm
Fruit length min:
8 cm
Fruit type :
follicle
Inflorescence :
umbel
Pollination syndrome :
insect
Pollination syndrome :
biotic
Seed mass max:
0.023237 g
Seed mass mean:
0.010136 g
Seed mass min:
0.002812 g
Self fertilization :
absent

Sources: Global Inventory of Floras and Traits (GIFT)

Plant Parts

Calotropis procera has 6 reported plant parts identified across 40 scientific publications and several other databases that are studied for medicinal purposes. The most consistently reported plant part include leaf, flower, root, stem, fruit.

Plant parts reported in Calotropis procera
Plant part Supporting sources Consensus
Leaf 19 supporting sources ★★★★★
Flower 9 supporting sources ★★★★☆
Root 5 supporting sources ★★★☆☆
Stem 5 supporting sources ★★★☆☆
Fruit 1 supporting sources ★☆☆☆☆
Seed 1 supporting sources ★☆☆☆☆

Leaf

  1. Dakar medical
  2. Nigerian quarterly journal of hospital medicine
  3. Heliyon
  4. Scientific reports
  5. Journal of Cancer
View 14 additional sources
  1. Microbial cell factories
  2. Neural plasticity
  3. 3 Biotech
  4. Pakistan journal of pharmaceutical sciences
  5. Parasite epidemiology and control
  6. Toxicology research
  7. Protein and peptide letters
  8. Tropical biomedicine
  9. Fitoterapia
  10. Iranian journal of pharmaceutical research : IJPR
  11. Plants (Basel, Switzerland)
  12. Natural product research
  13. Current topics in medicinal chemistry
  14. Molecular biotechnology

Flower

  1. Pakistan journal of pharmaceutical sciences
  2. Nigerian quarterly journal of hospital medicine
  3. Scientific reports
  4. Journal of parasitic diseases : official organ of the Indian Society for Parasitology
  5. Phytotherapy research : PTR
View 4 additional sources
  1. Journal of ethnopharmacology
  2. Parasitology
  3. Fitoterapia
  4. Pharmaceutical biology

Root

  1. Heliyon
  2. Fitoterapia
  3. Biomedical and environmental sciences : BES
  4. Journal of ethnopharmacology
  5. Fundamental & clinical pharmacology

Stem

  1. Scientific reports
  2. Microbial cell factories
  3. Fitoterapia
  4. Pharmaceutical biology
  5. Dakar medical

Fruit

  1. Scientific reports

Seed

  1. Scientific reports

Chemicals

Calotropis procera has 96 reported phytochemicals identified across 40 scientific publications and several other databases. The most consistently reported chemicals include Flavonoids, Tannins, Saponins, Glycosides, Cardenolides.

Chemicals reported in Calotropis procera
Chemical Supporting sources Consensus
Flavonoids 13 supporting sources ★★★★★
Tannins 11 supporting sources ★★★★★
Saponins 7 supporting sources ★★★★☆
Glycosides 5 supporting sources ★★★☆☆
Cardenolides 4 supporting sources ★★☆☆☆
Cardiac Glycosides 4 supporting sources ★★☆☆☆
Phenols 4 supporting sources ★★☆☆☆
CALOTROPIN 3 supporting sources ★★☆☆☆
Coumarins 3 supporting sources ★★☆☆☆
STIGMASTEROL 3 supporting sources ★★☆☆☆

Flavonoids

  1. Nigerian quarterly journal of hospital medicine
  2. Heliyon
  3. Journal of parasitic diseases : official organ of the Indian Society for Parasitology
  4. Journal of intercultural ethnopharmacology
  5. Research in veterinary science
View 8 additional sources
  1. The American journal of Chinese medicine
  2. Iranian journal of pharmaceutical research : IJPR
  3. Ecotoxicology and environmental safety
  4. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
  5. TheScientificWorldJournal
  6. Pharmaceutical biology
  7. Current topics in medicinal chemistry
  8. Archives of microbiology

Tannins

  1. Nigerian quarterly journal of hospital medicine
  2. Heliyon
  3. Journal of parasitic diseases : official organ of the Indian Society for Parasitology
  4. The American journal of Chinese medicine
  5. Iranian journal of pharmaceutical research : IJPR
View 6 additional sources
  1. Ecotoxicology and environmental safety
  2. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
  3. Natural product research
  4. Pharmaceutical biology
  5. Archives of microbiology
  6. African journal of traditional, complementary, and alternative medicines : AJTCAM

Saponins

  1. Nigerian quarterly journal of hospital medicine
  2. Heliyon
  3. Journal of parasitic diseases : official organ of the Indian Society for Parasitology
  4. Iranian journal of pharmaceutical research : IJPR
  5. Ecotoxicology and environmental safety
View 2 additional sources
  1. Pharmaceutical biology
  2. Archives of microbiology

Glycosides

  1. Nigerian quarterly journal of hospital medicine
  2. Heliyon
  3. Research in veterinary science
  4. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
  5. African journal of traditional, complementary, and alternative medicines : AJTCAM

Cardenolides

  1. Zeitschrift fur Naturforschung. C, Journal of biosciences
  2. Ecotoxicology and environmental safety
  3. Journal of plant research
  4. Current topics in medicinal chemistry

Cardiac Glycosides

  1. Scientific reports
  2. The American journal of Chinese medicine
  3. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
  4. Pharmaceutical biology

Phenols

  1. Heliyon
  2. Journal of parasitic diseases : official organ of the Indian Society for Parasitology
  3. Journal of intercultural ethnopharmacology
  4. Natural product research

CALOTROPIN

  1. Natural product research
  2. Zeitschrift fur Naturforschung. C, Journal of biosciences
  3. Journal of plant research

Coumarins

  1. Heliyon
  2. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
  3. Current topics in medicinal chemistry

STIGMASTEROL

  1. Plants (Basel, Switzerland)
  2. Fitoterapia
  3. Molecules (Basel, Switzerland)

Activities

Calotropis procera has 24 reported activities identified across 40 scientific publications and several other databases. The most consistently reported activities include Anticancer, Antioxidant, Antibacterial, Antimicrobial, Analgesic.

Activities reported in Calotropis procera
Activity Supporting sources Consensus
Anticancer 9 supporting sources ★★★★☆
Antioxidant 9 supporting sources ★★★★☆
Antibacterial 8 supporting sources ★★★★☆
Antimicrobial 6 supporting sources ★★★☆☆
Analgesic 5 supporting sources ★★★☆☆
Antipyretic 4 supporting sources ★★☆☆☆
Anthelmintic 2 supporting sources ★☆☆☆☆
Antifungal 2 supporting sources ★☆☆☆☆
Antiinflammatory 2 supporting sources ★☆☆☆☆
Cytotoxic 2 supporting sources ★☆☆☆☆

Anticancer

  1. Scientific reports
  2. Natural product research
  3. World journal of gastroenterology
  4. Microbial cell factories
  5. Zeitschrift fur Naturforschung. C, Journal of biosciences
View 4 additional sources
  1. Open veterinary journal
  2. 3 Biotech
  3. Frontiers in pharmacology
  4. Anti-cancer agents in medicinal chemistry

Antioxidant

  1. Scientific reports
  2. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
  3. Open veterinary journal
  4. Molecules (Basel, Switzerland)
  5. Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al
View 4 additional sources
  1. Heliyon
  2. Ecotoxicology and environmental safety
  3. Current topics in medicinal chemistry
  4. BMC complementary and alternative medicine

Antibacterial

  1. Plants (Basel, Switzerland)
  2. Journal of Cancer
  3. Phytotherapy research : PTR
  4. Toxicology research
  5. The American journal of Chinese medicine
View 3 additional sources
  1. Molecules (Basel, Switzerland)
  2. Natural product research
  3. Therapie

Antimicrobial

  1. Natural product research
  2. Microbial cell factories
  3. Open veterinary journal
  4. Molecules (Basel, Switzerland)
  5. Heliyon
View 1 additional sources
  1. Journal of ethnopharmacology

Analgesic

  1. Phytotherapy research : PTR
  2. Natural product research
  3. The American journal of Chinese medicine
  4. Heliyon
  5. Journal of ethnopharmacology

Antipyretic

  1. Phytotherapy research : PTR
  2. The American journal of Chinese medicine
  3. Heliyon
  4. Journal of ethnopharmacology

Anthelmintic

  1. Journal of parasitic diseases : official organ of the Indian Society for Parasitology
  2. Veterinary parasitology

Antifungal

  1. Toxicology research
  2. Molecules (Basel, Switzerland)

Antiinflammatory

  1. Phytotherapy research : PTR
  2. Journal of ethnopharmacology

Cytotoxic

  1. Journal of Cancer
  2. World journal of gastroenterology

Medicinal Uses

Calotropis procera has 90 reported medicinal uses identified across 40 scientific publications and several other databases. The most consistently reported uses include cancer, inflammation, Escherichia coli, analgesic, breast cancer.

Most Reported Uses

Use Sources Consensus
cancer Journal of ethnopharmacology (and other 7 sources) ★★★★☆
inflammation Nigerian quarterly journal of hospital medicine (and other 6 sources) ★★★☆☆
Escherichia coli Plants (Basel, Switzerland) (and other 3 sources) ★★☆☆☆
analgesic Natural product research (and other 3 sources) ★★☆☆☆
breast cancer Toxicology research (and other 3 sources) ★★☆☆☆
oxidative stress Inflammation research : official journal of the European Histamine Research Society ... [et al.] (and other 3 sources) ★★☆☆☆
Plasmodium falciparum Journal of ethnopharmacology (and other 2 sources) ★☆☆☆☆
cough Molecules (Basel, Switzerland) (and other 2 sources) ★☆☆☆☆
eczema Nigerian quarterly journal of hospital medicine (and other 2 sources) ★☆☆☆☆
fever The American journal of Chinese medicine (and other 2 sources) ★☆☆☆☆

Preparations

Preparations Sources Consensus
latex International journal of biological macromolecules (and other 13 sources) ★★★★★
ethanolic extract Scientific reports (and other 4 sources) ★★☆☆☆
leaves extract Plants (Basel, Switzerland) (and other 3 sources) ★★☆☆☆
crude extract Heliyon (and other 2 sources) ★☆☆☆☆
dried latex (DL) World journal of gastroenterology (and other 2 sources) ★☆☆☆☆
flowers Parasitology (and other 2 sources) ★☆☆☆☆
leaf extracts Parasite epidemiology and control (and other 2 sources) ★☆☆☆☆
1% polyvinyl alcohol biomembrane containing latex proteins (10%) Brazilian journal of biology = Revista brasleira de biologia (and other 1 sources) ★☆☆☆☆
2.5% solution of DL Journal of pharmacological and toxicological methods (and other 1 sources) ★☆☆☆☆
Aqueous Bark Extract Nigerian quarterly journal of hospital medicine (and other 1 sources) ★☆☆☆☆