Sodomís apple milkweed
Calotropis procera · Accepted scientific name
Scientific literature: Very Extensive (463 studies) · ★★★★★
Sodomís apple milkweed, scientifically known as Calotropis procera, is a versatile perennial shrub native to arid regions. Renowned in traditional medicine, its leaves, latex, and roots possess potent antibacterial and anti-inflammatory properties. This resilient plant offers significant therapeutic potential for treating various ailments, ranging from skin conditions to inflammation.
Names and Synonyms
Common Names
- Apple of Sodom
- Liberty Tree
- Sprain Leaf
- French-cotton
- Prince-of-Wales crown
- Sodom's-milkweed
- Sodom-apple
- apple-of-Sodom
- auricula-tree
- cabbagetree
- camelweed
- giant-milkweed
- kapoktree
- rubberbush
- rubbertree
- small crownflower
- swallowwort
- Seto / Gedla Akonda
- Tongue-Tongue
Scientific Names
Accepted name
Calotropis proceraSynonyms
- Calotropis syriaca
- Calotropis inflexa
- Apocynum syriacum
- Calotropis wallichii
- Asclepias procera
- Asclepias patula
- Madorius procerus
- Calotropis gigantea var. procera
- Calotropis hamiltonii
- Calotropis persica
- Calotropis procera subsp. hamiltonii
Regional and Traditional Names
Spanish:
- Calotropis persica
- Calotropis wallichii
- Madorius procerus
- Asclepias procera
- Calotropis inflexa
- Calotropis syriaca
- Calotropis busseana
- Asclepias gigantea
- Calotropis heterophylla
- Calotropis hamiltonii
- tula
- calotropis
- Algodoncillo gigante
- Algodón extranjero
- Manzano de Sodoma
- Mudar de la India
German:
- Oscher
- Fettblattbaum
- Mudarpflanze
- Oscherstrauch
- Fettblattbaum
- Judasapfel
- Oscher
French:
- Pommier de Sodome
- Thora thora
- Torcha
- Roustonnier
- arbre à soie
- calotrope
- Pommier de Sodome
Sources: Wikidata, Catalogue of Life
Taxonomical Classification
This plant belongs to the kingdom Plantae and is classified under the phylum Streptophyta and the class Equisetopsida. Within the subclass Magnoliidae and the order Gentianaales, it is situated in the family Apocynaceae. Finally, it is identified by its specific genus, Calotropis.
| Rank | Classification |
|---|---|
| Kingdom | Plantae |
| Phylum | Streptophyta |
| Class | Equisetopsida |
| Subclass | Magnoliidae |
| Order | Gentianales |
| Family | Apocynaceae |
| Genus | Calotropis |
Sources: The World Checklist of Vascular Plants (WCVP)
Distribution
This plant is widely distributed across several countries located within the Northern Africa region. It can be found growing naturally in the landscapes of Algeria. Additionally, the species is well-established throughout the territory of Egypt. Its presence extends further west to include the nation of Libya. Finally, this medicinal plant is also commonly documented in both Morocco and Tunisia.
| Region | Area |
|---|---|
| Northern Africa | Algeria |
| Northern Africa | Egypt |
| Northern Africa | Libya |
| Northern Africa | Morocco |
| Northern Africa | Tunisia |
| Northern Africa | Western Sahara |
| Macaronesia | Canary Is. |
| Macaronesia | Cape Verde |
| West Tropical Africa | Benin |
| West Tropical Africa | Burkina |
Sources: The World Checklist of Vascular Plants (WCVP)
Botanical Identification
Ecology
The ecology of Calotropis procera is characterized by its remarkable adaptability to diverse environmental conditions, ranging from sea level up to an elevation of 2720 m AMSL. It thrives in a variety of distinct ecosystems, demonstrating a broad ecological niche that includes anthropogenic areas (Área Antrópica), the semi-arid Caatinga (strict sensu), the tropical savanna of the Cerrado (lato sensu), and the coastal vegetation known as Restinga. This ability to inhabit both disturbed human-influenced landscapes and specialized natural biomes across a wide altitudinal gradient highlights its resilient nature and capacity to colonize varied topographical and climatic settings.
- Elevational range max:
- 2720 m AMSL
- Elevational range min:
- 0 m AMSL
- Habitat :
- Área Antrópica, Caatinga (stricto sensu), Cerrado (lato sensu), Restinga
Life history
The life history of Calotropis procera is characterized by its classification as a perennial plant, allowing it to persist in its environment over multiple growing seasons. As a phanerophyte, its regenerative buds are located on aerial shoots well above the ground, a structural adaptation that supports its growth habit. Specifically, it functions as both a phanerophyte and a nanophanerophyte, maintaining a woody or semi-woody stature that enables it to endure various environmental conditions throughout its extended lifespan.
- Life form :
- phanerophyte
- Lifecycle :
- perennial
Morphology
The morphology of Calotropis procera is characterized by its growth form as a woody shrub that functions as a self-supporting, independent plant. It is a terrestrial species, neither aquatic nor epiphytic, and does not exhibit parasitic behavior. In terms of stature, the plant reaches a minimum height of 1 m, with a mean height of approximately 4 m, and can attain a maximum height of up to 5 m.
- Aquatic :
- terrestrial
- Climber :
- self-supporting
- Epiphyte :
- terrestrial
- Growth form :
- shrub
- Parasite :
- independent
- Plant height max:
- 5 m
- Plant height mean:
- 4 m
- Plant height min:
- 1 m
- Woodiness :
- woody
Physiology
The physiology of Calotropis procera is characterized by specific morphological and metabolic adaptations suited for its environmental niche. The plant utilizes a C3 photosynthetic pathway to facilitate carbon fixation. Its foliage is defined by an opposite leaf arrangement, with individual leaves exhibiting an ovate form. These leaves can reach significant dimensions, with a maximum leaf length of 25 cm and a maximum leaf width of 22 cm. To manage water retention and survive in arid conditions, the plant exhibits succulence. Additionally, Calotropis procera does not function as a nitrogen fixer.
- Leaf arrangement :
- opposite
- Leaf form :
- ovate
- Leaf length max:
- 25 cm
- Leaf width max:
- 22 cm
- Nitrogen fixer :
- no
- Photosynthetic pathway :
- C3
- Succulence :
- yes
Reproduction
The reproduction of Calotropis procera is characterized by a biotic pollination syndrome, primarily facilitated by insects. The plant produces inflorescences in the form of an umbel, featuring flowers that exhibit a distinct violet colour. The flowering period typically begins in January and concludes in July, though it can be variable. Reproduction is dependent on cross-pollination, as self-fertilization is absent. Following successful pollination, the plant develops fruit classified as a follicle, with lengths ranging from a minimum of 8 cm to a maximum of 12 cm. The seeds produced within these follicles vary in mass, with a mean weight of 0.010136 g, a minimum of 0.002812 g, and a maximum of 0.023237 g. Once mature, the seeds are distributed via an anemochorous dispersal syndrome, utilizing wind to spread throughout the environment.
- Dispersal syndrome :
- anemochorous
- Flower colour :
- violet
- Flowering time :
- Jan
- Flowering time :
- Jul
- Fruit length max:
- 12 cm
- Fruit length min:
- 8 cm
- Fruit type :
- follicle
- Inflorescence :
- umbel
- Pollination syndrome :
- insect
- Pollination syndrome :
- biotic
- Seed mass max:
- 0.023237 g
- Seed mass mean:
- 0.010136 g
- Seed mass min:
- 0.002812 g
- Self fertilization :
- absent
Sources: Global Inventory of Floras and Traits (GIFT)
Plant Parts
Calotropis procera has 6 reported plant parts identified across 40 scientific publications and several other databases that are studied for medicinal purposes. The most consistently reported plant part include leaf, flower, root, stem, fruit.
| Plant part | Supporting sources | Consensus |
|---|---|---|
| Leaf | 19 supporting sources | ★★★★★ |
| Flower | 9 supporting sources | ★★★★☆ |
| Root | 5 supporting sources | ★★★☆☆ |
| Stem | 5 supporting sources | ★★★☆☆ |
| Fruit | 1 supporting sources | ★☆☆☆☆ |
| Seed | 1 supporting sources | ★☆☆☆☆ |
Leaf
- Dakar medical
- Nigerian quarterly journal of hospital medicine
- Heliyon
- Scientific reports
- Journal of Cancer
View 14 additional sources
- Microbial cell factories
- Neural plasticity
- 3 Biotech
- Pakistan journal of pharmaceutical sciences
- Parasite epidemiology and control
- Toxicology research
- Protein and peptide letters
- Tropical biomedicine
- Fitoterapia
- Iranian journal of pharmaceutical research : IJPR
- Plants (Basel, Switzerland)
- Natural product research
- Current topics in medicinal chemistry
- Molecular biotechnology
Flower
- Pakistan journal of pharmaceutical sciences
- Nigerian quarterly journal of hospital medicine
- Scientific reports
- Journal of parasitic diseases : official organ of the Indian Society for Parasitology
- Phytotherapy research : PTR
View 4 additional sources
- Journal of ethnopharmacology
- Parasitology
- Fitoterapia
- Pharmaceutical biology
Root
- Heliyon
- Fitoterapia
- Biomedical and environmental sciences : BES
- Journal of ethnopharmacology
- Fundamental & clinical pharmacology
Stem
- Scientific reports
- Microbial cell factories
- Fitoterapia
- Pharmaceutical biology
- Dakar medical
Fruit
- Scientific reports
Seed
- Scientific reports
Chemicals
Calotropis procera has 96 reported phytochemicals identified across 40 scientific publications and several other databases. The most consistently reported chemicals include Flavonoids, Tannins, Saponins, Glycosides, Cardenolides.
| Chemical | Supporting sources | Consensus |
|---|---|---|
| Flavonoids | 13 supporting sources | ★★★★★ |
| Tannins | 11 supporting sources | ★★★★★ |
| Saponins | 7 supporting sources | ★★★★☆ |
| Glycosides | 5 supporting sources | ★★★☆☆ |
| Cardenolides | 4 supporting sources | ★★☆☆☆ |
| Cardiac Glycosides | 4 supporting sources | ★★☆☆☆ |
| Phenols | 4 supporting sources | ★★☆☆☆ |
| CALOTROPIN | 3 supporting sources | ★★☆☆☆ |
| Coumarins | 3 supporting sources | ★★☆☆☆ |
| STIGMASTEROL | 3 supporting sources | ★★☆☆☆ |
Flavonoids
- Nigerian quarterly journal of hospital medicine
- Heliyon
- Journal of parasitic diseases : official organ of the Indian Society for Parasitology
- Journal of intercultural ethnopharmacology
- Research in veterinary science
View 8 additional sources
- The American journal of Chinese medicine
- Iranian journal of pharmaceutical research : IJPR
- Ecotoxicology and environmental safety
- Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
- TheScientificWorldJournal
- Pharmaceutical biology
- Current topics in medicinal chemistry
- Archives of microbiology
Tannins
- Nigerian quarterly journal of hospital medicine
- Heliyon
- Journal of parasitic diseases : official organ of the Indian Society for Parasitology
- The American journal of Chinese medicine
- Iranian journal of pharmaceutical research : IJPR
View 6 additional sources
- Ecotoxicology and environmental safety
- Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
- Natural product research
- Pharmaceutical biology
- Archives of microbiology
- African journal of traditional, complementary, and alternative medicines : AJTCAM
Saponins
- Nigerian quarterly journal of hospital medicine
- Heliyon
- Journal of parasitic diseases : official organ of the Indian Society for Parasitology
- Iranian journal of pharmaceutical research : IJPR
- Ecotoxicology and environmental safety
View 2 additional sources
- Pharmaceutical biology
- Archives of microbiology
Glycosides
- Nigerian quarterly journal of hospital medicine
- Heliyon
- Research in veterinary science
- Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
- African journal of traditional, complementary, and alternative medicines : AJTCAM
Cardenolides
- Zeitschrift fur Naturforschung. C, Journal of biosciences
- Ecotoxicology and environmental safety
- Journal of plant research
- Current topics in medicinal chemistry
Cardiac Glycosides
- Scientific reports
- The American journal of Chinese medicine
- Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
- Pharmaceutical biology
Phenols
- Heliyon
- Journal of parasitic diseases : official organ of the Indian Society for Parasitology
- Journal of intercultural ethnopharmacology
- Natural product research
CALOTROPIN
- Natural product research
- Zeitschrift fur Naturforschung. C, Journal of biosciences
- Journal of plant research
Coumarins
- Heliyon
- Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
- Current topics in medicinal chemistry
STIGMASTEROL
- Plants (Basel, Switzerland)
- Fitoterapia
- Molecules (Basel, Switzerland)
Activities
Calotropis procera has 24 reported activities identified across 40 scientific publications and several other databases. The most consistently reported activities include Anticancer, Antioxidant, Antibacterial, Antimicrobial, Analgesic.
| Activity | Supporting sources | Consensus |
|---|---|---|
| Anticancer | 9 supporting sources | ★★★★☆ |
| Antioxidant | 9 supporting sources | ★★★★☆ |
| Antibacterial | 8 supporting sources | ★★★★☆ |
| Antimicrobial | 6 supporting sources | ★★★☆☆ |
| Analgesic | 5 supporting sources | ★★★☆☆ |
| Antipyretic | 4 supporting sources | ★★☆☆☆ |
| Anthelmintic | 2 supporting sources | ★☆☆☆☆ |
| Antifungal | 2 supporting sources | ★☆☆☆☆ |
| Antiinflammatory | 2 supporting sources | ★☆☆☆☆ |
| Cytotoxic | 2 supporting sources | ★☆☆☆☆ |
Anticancer
- Scientific reports
- Natural product research
- World journal of gastroenterology
- Microbial cell factories
- Zeitschrift fur Naturforschung. C, Journal of biosciences
View 4 additional sources
- Open veterinary journal
- 3 Biotech
- Frontiers in pharmacology
- Anti-cancer agents in medicinal chemistry
Antioxidant
- Scientific reports
- Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
- Open veterinary journal
- Molecules (Basel, Switzerland)
- Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al
View 4 additional sources
- Heliyon
- Ecotoxicology and environmental safety
- Current topics in medicinal chemistry
- BMC complementary and alternative medicine
Antibacterial
- Plants (Basel, Switzerland)
- Journal of Cancer
- Phytotherapy research : PTR
- Toxicology research
- The American journal of Chinese medicine
View 3 additional sources
- Molecules (Basel, Switzerland)
- Natural product research
- Therapie
Antimicrobial
- Natural product research
- Microbial cell factories
- Open veterinary journal
- Molecules (Basel, Switzerland)
- Heliyon
View 1 additional sources
- Journal of ethnopharmacology
Analgesic
- Phytotherapy research : PTR
- Natural product research
- The American journal of Chinese medicine
- Heliyon
- Journal of ethnopharmacology
Antipyretic
- Phytotherapy research : PTR
- The American journal of Chinese medicine
- Heliyon
- Journal of ethnopharmacology
Anthelmintic
- Journal of parasitic diseases : official organ of the Indian Society for Parasitology
- Veterinary parasitology
Antifungal
- Toxicology research
- Molecules (Basel, Switzerland)
Antiinflammatory
- Phytotherapy research : PTR
- Journal of ethnopharmacology
Cytotoxic
- Journal of Cancer
- World journal of gastroenterology
Medicinal Uses
Calotropis procera has 90 reported medicinal uses identified across 40 scientific publications and several other databases. The most consistently reported uses include cancer, inflammation, Escherichia coli, analgesic, breast cancer.
Most Reported Uses
| Use | Sources | Consensus |
|---|---|---|
| cancer | Journal of ethnopharmacology (and other 7 sources) | ★★★★☆ |
| inflammation | Nigerian quarterly journal of hospital medicine (and other 6 sources) | ★★★☆☆ |
| Escherichia coli | Plants (Basel, Switzerland) (and other 3 sources) | ★★☆☆☆ |
| analgesic | Natural product research (and other 3 sources) | ★★☆☆☆ |
| breast cancer | Toxicology research (and other 3 sources) | ★★☆☆☆ |
| oxidative stress | Inflammation research : official journal of the European Histamine Research Society ... [et al.] (and other 3 sources) | ★★☆☆☆ |
| Plasmodium falciparum | Journal of ethnopharmacology (and other 2 sources) | ★☆☆☆☆ |
| cough | Molecules (Basel, Switzerland) (and other 2 sources) | ★☆☆☆☆ |
| eczema | Nigerian quarterly journal of hospital medicine (and other 2 sources) | ★☆☆☆☆ |
| fever | The American journal of Chinese medicine (and other 2 sources) | ★☆☆☆☆ |
Preparations
| Preparations | Sources | Consensus |
|---|---|---|
| latex | International journal of biological macromolecules (and other 13 sources) | ★★★★★ |
| ethanolic extract | Scientific reports (and other 4 sources) | ★★☆☆☆ |
| leaves extract | Plants (Basel, Switzerland) (and other 3 sources) | ★★☆☆☆ |
| crude extract | Heliyon (and other 2 sources) | ★☆☆☆☆ |
| dried latex (DL) | World journal of gastroenterology (and other 2 sources) | ★☆☆☆☆ |
| flowers | Parasitology (and other 2 sources) | ★☆☆☆☆ |
| leaf extracts | Parasite epidemiology and control (and other 2 sources) | ★☆☆☆☆ |
| 1% polyvinyl alcohol biomembrane containing latex proteins (10%) | Brazilian journal of biology = Revista brasleira de biologia (and other 1 sources) | ★☆☆☆☆ |
| 2.5% solution of DL | Journal of pharmacological and toxicological methods (and other 1 sources) | ★☆☆☆☆ |
| Aqueous Bark Extract | Nigerian quarterly journal of hospital medicine (and other 1 sources) | ★☆☆☆☆ |