Callicarpa integerrima
Callicarpa integerrima · Accepted scientific name
Scientific literature: Very Sparse (1 studies) · ★☆☆☆☆
Callicarpa integerrima is a botanical species notable for the diverse chemical profile found within its foliage. The essential oil extracted from its leaves serves as a concentrated source of bioactive compounds, including alpha-caryophyllene and 1,6-cyclodecadiene. Scientific analysis further identifies the presence of specialized constituents such as (-)-spathulenol and various clerodane diterpenoids. These specific chemical markers contribute significantly to the plant's documented antimicrobial activities. Consequently, this species represents a promising subject for research into natural therapeutic agents.
- Synonyms
- Not available
- Common names
- Not available
- Family
- Lamiaceae
- Distribution
- Asia-Temperate
- Plant Parts
- Leaf
Classification
Taxonomy
Callicarpa integerrima belongs to the vast kingdom Plantae, representing the diverse world of living vegetation. Within this kingdom, the species is classified under the class Equisetopsida. It further belongs to the order Lamiales, a group that shares specific structural characteristics. This plant is a member of the Lamiaceae family, which is known for its distinct botanical traits. Ultimately, it is defined by its classification within the genus Callicarpa.
| Rank | Classification |
|---|---|
| Kingdom | Plantae |
| Phylum | Streptophyta |
| Class | Equisetopsida |
| Subclass | Magnoliidae |
| Order | Lamiales |
| Family | Lamiaceae |
| Genus | Callicarpa |
Sources: The World Checklist of Vascular Plants (WCVP)
Distribution
Geographic Regions
Callicarpa integerrima is a plant species characterized by a specific geographic range within the Asia-Temperate region. Its natural distribution is primarily centered within the diverse landscapes of China. Specifically, the species can be found throughout the China South-Central area. Furthermore, it maintains a significant presence in the China Southeast region as well. These distinct locations highlight the plant's localized ecological niche within the continent.
Sources: The World Checklist of Vascular Plants (WCVP)
Identification
Morphology
Callicarpa integerrima exhibits a facultative climbing habit, allowing it to adapt its growth pattern to climb when necessary.
Sources: Global Inventory of Floras and Traits (GIFT)
Biological Activities
Callicarpa integerrima has demonstrated significant potential in the fight against antibiotic resistance due to its inherent antimicrobial activity. Using a highly efficient nanoliter matrix SlipChip, researchers were able to screen compounds from this plant with minimal sample consumption. This high-throughput method successfully identified two previously unreported clerodane diterpenes isolated from the species. These specific compounds showed effective activity against methicillin-resistant Staphylococcus aureus (MRSA) by disrupting bacterial cell membranes and biofilms. Such findings highlight the importance of utilizing advanced screening technologies to discover novel drugs from natural plant sources.
Compounds
Callicarpa integerrima is a chemically diverse plant species that possesses a rich array of bioactive secondary metabolites. Chemical analysis of its essential oils reveals that the plant contains significant amounts of both beta-caryophyllene and alpha-caryophyllene. Furthermore, phytochemical investigations have successfully isolated various specialized molecules, including the specific derivative known as compound 6. The plant is also a notable source of clerodane diterpenes, which have shown promise in combating resistant bacterial strains. These various clerodane diterpenoids contribute to the plant's significant potential in both anti-inflammatory and antimicrobial medicinal research.
Conditions
Callicarpa integerrima exhibits significant anti-inflammatory activity through its diverse bioactive compounds. Specifically, various isolated diterpenoids from the plant demonstrate the ability to treat NLRP3 inflammasome activation. These components also effectively treat NLRP3 inflammasome-induced pyroptosis and suppress IL-1β secretion in macrophage cells. Beyond these inflammatory pathways, the plant contains compounds that demonstrate potent anti-MRSA activity. Together, these pharmacological properties highlight the multifaceted therapeutic potential of Callicarpa integerrima.
Preparations
Callicarpa integerrima is prepared as an essential oil derived specifically from its leaves. Researchers utilized the GC-MS method to conduct a detailed analysis of the chemical compositions within this oil. The extraction process revealed 42 identified chemical constituents that account for 97.62% of the total content. Major components found in the oil include beta-caryophyllene, Elixene, tau-Cadinene, and (-) -Spathulenol. Additionally, various sesquiterpenes and their oxides contribute to the complex profile of the extracted essential oil.
Parts used
Callicarpa integerrima possesses unique chemical properties that are particularly concentrated within its leaves. Recent analytical studies have focused on extracting and examining the essential oils derived specifically from this plant part. By employing the GC-MS method, researchers successfully identified 42 distinct chemical constituents within the leaf extract. The analysis revealed that beta-caryophyllene serves as the primary component, followed by significant amounts of Elixene and tau-Cadinene. These findings highlight the complex profile of sesquiterpenes and oxides that define the botanical makeup of the species.