10 Medicinal Constituents Of Calendula Officinalis (Pot Marigold)

Calendula officinalis has active constituents such as carotenoids, flavonoids, and triterpenoids.

These constituents possess anti-inflammatory, antimicrobial, and antioxidant properties. They can improve wound healing, reduce skin irritation, and soothe sunburns.

For example, patients with chronic wounds or skin ulcers can experience faster healing and reduced scarring with topical calendula applications, improving their quality of life and mobility.

This article explains in details the 10 best active constituents of Calendula officinalis.

1. Quercetin

Calendula officinalis quercetin is a bioactive flavonoid compound found in its flowers.

Quercetin has been extensively studied for its various biological activities, including anti-inflammatory, antioxidant, and immunomodulatory properties.

It has been shown to possess significant protective effects against oxidative stress, inflammation, and cell damage, making it a promising natural therapeutic agent for the treatment of several diseases, including cancer, cardiovascular disorders, and allergies.

2. Kaempferol

Calendula officinalis kaempferol is a flavonoid glycoside that has been isolated from its flowers.

This bioactive compound exhibits various pharmacological activities, including antioxidant, anti-inflammatory, and antimicrobial properties. Kaempferol has also been reported to possess antitumor and immunomodulatory effects, making it a promising candidate for the treatment of various diseases, such as cancer, cardiovascular disorders, and inflammatory conditions.

Its potential uses are being explored in traditional medicine and pharmaceutical research.

3. Luteolin

Calendula officinalis luteolin is a flavonoid compound found in the flowers of the plant.

It has been traditionally used for its anti-inflammatory and antimicrobial properties, making it useful for wound healing, skin irritations, and digestive issues.

Luteolin has also been shown to exhibit antioxidant and immunomodulatory effects, potentially contributing to its therapeutic benefits.

4. Apigenin

Calendula officinalis apigenin is a flavonoid compound found in the flowers of this plant.

It has been traditionally used for its anti-inflammatory and antimicrobial properties. Studies have shown that apigenin exhibits antioxidant, antiviral, and anticancer activities, making it a potential therapeutic agent for various diseases.

Additionally, apigenin has been reported to possess neuroprotective effects and may help in the treatment of neurodegenerative disorders.

5. Beta-sitosterol

Calendula officinalis beta-sitosterol is a type of phytosterol that has been extracted from the plant's flowers.

It has been shown to possess anti-inflammatory and antioxidant properties, making it a potential natural remedy for various health issues. Beta-sitosterol has also been found to have cholesterol-lowering effects, which may help in preventing heart diseases.

Additionally, its antibacterial and antifungal properties make it effective against skin infections.

6. Linolenic acid

Calendula officinalis linolenic acid is a type of omega-3 fatty acid found in its flowers.

This acid has been traditionally used to soothe and calm skin irritations, wounds, and burns due to its anti-inflammatory properties. It is also believed to promote wound healing by enhancing collagen synthesis and improving skin elasticity.

The use of Calendula officinalis linolenic acid is particularly beneficial for treating acne, eczema, and psoriasis.

7. Oleic acid

Calendula officinalis oleic acid is a fatty acid derived from its flowers.

It has been used in traditional medicine and cosmetics due to its anti-inflammatory, antimicrobial, and antioxidant properties. Oleic acid has been shown to exhibit wound-healing effects, reducing inflammation and promoting tissue regeneration.

Additionally, it may help soothe skin irritations and reduce the appearance of fine lines and wrinkles, making it a popular ingredient in skincare products.

8. Palmitoleic acid

Calendula officinalis palmitoleic acid is a rare and beneficial fatty acid found in its flowers.

This essential omega-7 fatty acid has been shown to have numerous health benefits, including reducing inflammation, improving skin elasticity, and promoting wound healing.

It has also been linked to improved cardiovascular health and may even help to reduce the risk of certain diseases such as cancer and diabetes.

9. Calendulin

Calendula officinalis calendulin is a triterpenoid saponin derived from the flowers of the plant.

It has been traditionally used in herbal medicine for its anti-inflammatory and antimicrobial properties, making it effective in treating wounds, skin conditions, and eye irritations. Calendulin has also been shown to exhibit antioxidant activity and may have potential as an anticancer agent.

Its uses are varied and continue to be explored through scientific research.

10. Heteroside

Calendula officinalis heteroside is a type of triterpenoid saponin compound that has been traditionally used in herbal medicine for its anti-inflammatory and antimicrobial properties.

Research has shown that calendula heteroside exhibits potent antioxidant activity, making it effective against various diseases, including cancer, cardiovascular disorders, and neurodegenerative conditions.

Its ability to inhibit pro-inflammatory cytokines also makes it a potential treatment for skin conditions such as acne and psoriasis.