Zi cao

Arnebia euchroma · Accepted scientific name

Scientific literature: Moderate (132 studies) · ★★★☆☆

Zi cao, scientifically known as Arnebia euchroma, is a perennial herb renowned in traditional Chinese medicine for its potent therapeutic properties. Rich in shikonin derivatives, this plant is widely utilized to treat inflammation, skin infections, and promote wound healing, making it a vital component in various dermatological treatments.

Family
Boraginaceae
Native range
Asia-Temperate
Parts used
Root · Leaf
Common names
Sinkiang-Tibet Arnebia
Scientific synonyms
Macrotomia Euchromon · Lithospermum Euchromon

Names and Synonyms

Common Names

Scientific Names

Accepted name

Arnebia euchroma

Synonyms

Sources: Wikidata, Catalogue of Life

Taxonomical Classification

This plant belongs to the kingdom Plantae and is classified under the phylum Streptophyta and the class Equisetopsida. Within the subclass Magnoliidae, it is placed in the order Boraginales and the family Boraginaceae. Finally, its specific taxonomic identity is defined by the genus Arnebia.

Rank Classification
Kingdom Plantae
Phylum Streptophyta
Class Equisetopsida
Subclass Magnoliidae
Order Boraginales
Family Boraginaceae
Genus Arnebia

Sources: The World Checklist of Vascular Plants (WCVP)

Distribution

This plant is primarily distributed across the vast landscapes of Central Asia. It can be found growing naturally within the borders of Kazakhstan. Its presence is also documented throughout the mountainous and arid regions of Kirgizstan. Furthermore, the species inhabits various territories in Turkmenistan and Tadzhikistan. Finally, the geographical range of this medicinal herb extends into Uzbekistan.

Region Area
Central Asia Kazakhstan
Central Asia Kirgizstan
Central Asia Turkmenistan
Central Asia Tadzhikistan
Central Asia Uzbekistan
Western Asia Afghanistan
Western Asia Iran
China Tibet
China Xinjiang
Indian Subcontinent Nepal

Sources: The World Checklist of Vascular Plants (WCVP)

Botanical Identification

Ecology

The ecology of Arnebia euchroma is characterized by its adaptation to high-altitude alpine environments, typically thriving in mountainous regions and stony places. This species occupies a specific vertical niche within its ecosystem, with an elevational range spanning from a minimum of 2500 m AMSL to a maximum of 4400 m AMSL. On average, the plant is found at a mean elevation of 3350 m AMSL, where the rugged, rocky terrain provides the necessary substrate for its growth.

Elevational range max:
4400 m AMSL
Elevational range mean:
3350 m AMSL
Elevational range min:
2500 m AMSL
Habitat :
mountains, stony places

Life history

The life history of Arnebia euchroma is characterized by its status as a perennial plant, allowing it to persist through multiple growing seasons rather than completing its life cycle in a single year. As a perennial herb, it establishes a robust root system that stores essential nutrients and water, enabling the plant to survive periods of dormancy and emerge repeatedly from the soil. This lifecycle supports a developmental pattern where the plant can invest significant energy into the production of its characteristic deep red or purple pigments and medicinal compounds over several years. Throughout its lifespan, it undergoes seasonal cycles of vegetative growth and flowering, with its ability to endure long-term environmental fluctuations contributing to its stability in its natural habitat.

Lifecycle :
perennial

Morphology

The morphology of Arnebia euchroma is characterized by its growth form as a non-woody herb, specifically categorized as a forb. As a terrestrial plant, it does not exhibit aquatic or semiaquatic tendencies, nor does it function as an epiphyte. The species is a self-supporting organism, lacking any climber, liana, or vine-like structures, and it maintains an independent lifestyle without acting as a parasite. Its physical structure is entirely non-woody, reinforcing its classification as a herbaceous plant.

Aquatic :
terrestrial
Climber :
self-supporting
Epiphyte :
terrestrial
Growth form :
herb
Parasite :
independent
Woodiness :
non-woody

Reproduction

The reproduction of Arnebia euchroma is characterized by a specific flowering phenology and the development of small, uniform fruit structures. The flowering period typically begins in June and concludes in July, although the timing can be variable depending on environmental conditions. During the reproductive phase, the plant produces inflorescences that range in length from a minimum of 0.02 m to a maximum of 0.06 m. Following pollination, the plant develops fruits that exhibit highly consistent dimensions; the fruit length is measured at a steady 0.35 cm, with no variation between the minimum, mean, and maximum values. Similarly, the fruit width remains constant at 0.3 cm, with the minimum, mean, and maximum measurements all aligning at this exact value.

Flowering time :
Jun
Flowering time :
Jul
Fruit length max:
0.35 cm
Fruit width max:
0.3 cm
Inflorescence length max:
0.06 m
Inflorescence length min:
0.02 m

Sources: Global Inventory of Floras and Traits (GIFT)

Plant Parts

Arnebia euchroma has 4 reported plant parts identified across 12 scientific publications and several other databases that are studied for medicinal purposes. The most consistently reported plant part include root, leaf, rhizome, stem.

Plant parts reported in Arnebia euchroma
Plant part Supporting sources Consensus
Root 9 supporting sources ★★★★☆
Leaf 1 supporting sources ★☆☆☆☆
Rhizome 1 supporting sources ★☆☆☆☆
Stem 1 supporting sources ★☆☆☆☆

Root

  1. Frontiers in plant science
  2. Chemical & pharmaceutical bulletin
  3. Scientific reports
  4. Journal of ethnopharmacology
  5. Molecules (Basel, Switzerland)
View 4 additional sources
  1. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  2. Recent patents on biotechnology
  3. BMC plant biology
  4. The American journal of Chinese medicine

Leaf

  1. Molecules (Basel, Switzerland)

Rhizome

  1. International journal of antimicrobial agents

Stem

  1. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

Chemicals

Arnebia euchroma has 39 reported phytochemicals identified across 12 scientific publications and several other databases. The most consistently reported chemicals include shikonin, Acetylshikonin, Flavonoids, Arnebinone, Deoxyshikonin.

Chemicals reported in Arnebia euchroma
Chemical Supporting sources Consensus
shikonin 12 supporting sources ★★★★★
Acetylshikonin 3 supporting sources ★★☆☆☆
Flavonoids 3 supporting sources ★★☆☆☆
Arnebinone 2 supporting sources ★☆☆☆☆
Deoxyshikonin 2 supporting sources ★☆☆☆☆
Naphthoquinones 2 supporting sources ★☆☆☆☆
4-Coumaric acid 1 supporting sources ★☆☆☆☆
Activated charcoal 1 supporting sources ★☆☆☆☆
Alkannin 1 supporting sources ★☆☆☆☆
Anthocyanins 1 supporting sources ★☆☆☆☆

shikonin

  1. FEMS yeast research
  2. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
  3. Scientific reports
  4. Journal of ethnopharmacology
  5. Plant physiology and biochemistry : PPB
View 7 additional sources
  1. Journal of natural products
  2. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  3. Journal of biomolecular screening
  4. Recent patents on biotechnology
  5. Applied biochemistry and biotechnology
  6. Biochimica et biophysica acta
  7. The American journal of Chinese medicine

Acetylshikonin

  1. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  2. Recent patents on biotechnology
  3. Biochimica et biophysica acta

Flavonoids

  1. Frontiers in plant science
  2. Molecules (Basel, Switzerland)
  3. BMC plant biology

Arnebinone

  1. Journal of ethnopharmacology
  2. Chemical & pharmaceutical bulletin

Deoxyshikonin

  1. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  2. Recent patents on biotechnology

Naphthoquinones

  1. Molecules (Basel, Switzerland)
  2. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

4-Coumaric acid

  1. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

Activated charcoal

  1. Cell biology international

Alkannin

  1. Journal of natural products

Anthocyanins

  1. BMC plant biology

Activities

Arnebia euchroma has 6 reported activities identified across 12 scientific publications and several other databases. The most consistently reported activities include Anticancer, Antimicrobial, Antioxidant, Antiviral, Chemopreventive.

Activities reported in Arnebia euchroma
Activity Supporting sources Consensus
Anticancer 2 supporting sources ★☆☆☆☆
Antimicrobial 2 supporting sources ★☆☆☆☆
Antioxidant 2 supporting sources ★☆☆☆☆
Antiviral 1 supporting sources ★☆☆☆☆
Chemopreventive 1 supporting sources ★☆☆☆☆
Hepatoprotective 1 supporting sources ★☆☆☆☆

Anticancer

  1. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  2. Recent patents on biotechnology

Antimicrobial

  1. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  2. Recent patents on biotechnology

Antioxidant

  1. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  2. Recent patents on biotechnology

Antiviral

  1. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

Chemopreventive

  1. Journal of biomolecular screening

Hepatoprotective

  1. Journal of ethnopharmacology

Conditions

Arnebia euchroma has 20 reported investigations on conditions identified across 12 scientific publications and several other databases. The most consistently reported conditions include inflammation, EV-A71, antioxidant, antiviral, cancer.

Conditions investigated for Arnebia euchroma
Condition Supporting sources Consensus
Inflammation 3 supporting sources ★★☆☆☆
Ev-a71 1 supporting sources ★☆☆☆☆
Antioxidant 1 supporting sources ★☆☆☆☆
Antiviral 1 supporting sources ★☆☆☆☆
Cancer 1 supporting sources ★☆☆☆☆
Chronic diseases 1 supporting sources ★☆☆☆☆
Colitis 1 supporting sources ★☆☆☆☆
Dermatitis 1 supporting sources ★☆☆☆☆
Diarrhea 1 supporting sources ★☆☆☆☆
Eczema 1 supporting sources ★☆☆☆☆

Inflammation

  1. Pharmaceutics
  2. World journal of gastroenterology
  3. Journal of biomolecular screening

Ev-a71

  1. International journal of antimicrobial agents

Antioxidant

  1. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

Antiviral

  1. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

Cancer

  1. Journal of natural products

Chronic diseases

  1. Journal of ethnopharmacology

Colitis

  1. World journal of gastroenterology

Dermatitis

  1. Recent patents on biotechnology

Diarrhea

  1. World journal of gastroenterology

Eczema

  1. Recent patents on biotechnology

Preparations

Arnebia euchroma has 19 reported preparations identified across 12 scientific publications and several other databases. The most consistently reported preparations include Arnebia euchroma Oiintment, Cell suspension cultures, Sephadex column chromatography, cell suspension cultures, chloroform extracts.

Preparations reported for Arnebia euchroma
Preparation Supporting sources Consensus
Arnebia euchroma oiintment 1 supporting sources ★☆☆☆☆
Cell suspension cultures 1 supporting sources ★☆☆☆☆
Sephadex column chromatography 1 supporting sources ★☆☆☆☆
Cell suspension cultures 1 supporting sources ★☆☆☆☆
Chloroform extracts 1 supporting sources ★☆☆☆☆
Distilled water extraction 1 supporting sources ★☆☆☆☆
Dried root 1 supporting sources ★☆☆☆☆
Dried roots 1 supporting sources ★☆☆☆☆
Ethanol fractionation 1 supporting sources ★☆☆☆☆
Extract of arnebia euchroma 1 supporting sources ★☆☆☆☆

Arnebia euchroma oiintment

  1. Iranian Red Crescent medical journal

Cell suspension cultures

  1. Applied biochemistry and biotechnology

Sephadex column chromatography

  1. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

Cell suspension cultures

  1. Cell biology international

Chloroform extracts

  1. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

Distilled water extraction

  1. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

Dried root

  1. The American journal of Chinese medicine

Dried roots

  1. Frontiers in plant science

Ethanol fractionation

  1. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

Extract of arnebia euchroma

  1. Journal of natural products