birthwort

Aristolochia · Accepted scientific name

Scientific literature: Sparse (81 studies) · ★★☆☆☆

Birthwort, scientifically known as Aristolochia, is a genus of flowering plants valued historically in traditional medicine. While once used to treat inflammation and respiratory issues, modern science warns of its potent nephrotoxicity. Due to the risk of aristolochic acid, many species are now strictly regulated or avoided globally.

Family
Aristolochiaceae
Native range
Europe
Parts used
Root · Seed
Common names
Birthwort · Dutchman'S-Pipe · 1 more
Scientific synonyms
Hocquartia · Hexaplectris · 17 more

Names and Synonyms

Common Names

Scientific Names

Accepted name

Aristolochia

Synonyms

Regional and Traditional Names

Spanish:

  • Patitos
  • Yerba de la virgen María

German:

  • Pfeifenblumen
  • Gespensterpflanze
  • Pfeifenblume
  • Osterluzei
  • Pfeifenblumen

French:

  • Aristoloche
  • Aristoloches
  • Aristoloche

Sources: Wikidata, Catalogue of Life

Taxonomical Classification

This plant belongs to the kingdom Plantae and the phylum Streptophyta, falling under the class Equisetopsida and subclass Magnoliidae. It is further classified within the order Piperales and the family Aristolochiaceae. Ultimately, this medicinal specimen is identified by the genus Aristolochia.

Rank Classification
Kingdom Plantae
Phylum Streptophyta
Class Equisetopsida
Subclass Magnoliidae
Order Piperales
Family Aristolochiaceae
Genus Aristolochia

Sources: The World Checklist of Vascular Plants (WCVP)

Distribution

This plant exhibits a specific geographical range across several regions of the European continent. In Northern Europe, its presence is documented in Denmark and Great Britain. The distribution extends further north to include the territories of Norway and Sweden. Additionally, its habitat reaches into Middle Europe, specifically within Austria. Together, these locations define the known environmental scope for the Aristolochia species.

Region Area
Northern Europe Denmark
Northern Europe Great Britain
Northern Europe Norway
Northern Europe Sweden
Middle Europe Austria
Middle Europe Belgium
Middle Europe Czechia-Slovakia
Middle Europe Germany
Middle Europe Hungary
Middle Europe Netherlands

Sources: The World Checklist of Vascular Plants (WCVP)

Plant Parts

Aristolochia has 2 reported plant parts identified across 2 scientific publications and several other databases that are studied for medicinal purposes. The most consistently reported plant part include root, seed.

Plant parts reported in Aristolochia
Plant part Supporting sources Consensus
Root 1 supporting sources ★☆☆☆☆
Seed 1 supporting sources ★☆☆☆☆

Root

  1. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

Seed

  1. Toxicology research

Chemicals

Aristolochia has 14 reported phytochemicals identified across 2 scientific publications and several other databases. The most consistently reported chemicals include Aristolochic acids, Aristolochic acid I, Aristolochic acid II, Aristolochic acid, Aristolactam I.

Chemicals reported in Aristolochia
Chemical Supporting sources Consensus
Aristolochic acids 15 supporting sources ★★★★★
Aristolochic acid I 8 supporting sources ★★★★☆
Aristolochic acid II 7 supporting sources ★★★★☆
Aristolochic acid 5 supporting sources ★★★☆☆
Aristolactam I 2 supporting sources ★☆☆☆☆
AA 1 supporting sources ★☆☆☆☆
AAI 1 supporting sources ★☆☆☆☆
AANA 1 supporting sources ★☆☆☆☆
ALI 1 supporting sources ★☆☆☆☆
Aristolactam bi 1 supporting sources ★☆☆☆☆

Aristolochic acids

  1. Journal of ethnopharmacology
  2. Toxicology research
  3. Analytical chemistry
  4. Toxicology letters
  5. The Journal of pharmacy and pharmacology
View 10 additional sources
  1. Toxicology and applied pharmacology
  2. Journal of agricultural and food chemistry
  3. Journal of pharmaceutical and biomedical analysis
  4. Chemical research in toxicology
  5. International journal of molecular sciences
  6. Fitoterapia
  7. Environmental and molecular mutagenesis
  8. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  9. Food chemistry
  10. Carcinogenesis

Aristolochic acid I

  1. Analytical chemistry
  2. Journal of separation science
  3. Toxicology letters
  4. Journal of chromatography. A
  5. Journal of natural products
View 3 additional sources
  1. Die Pharmazie
  2. Journal of ethnopharmacology
  3. Talanta

Aristolochic acid II

  1. Journal of separation science
  2. Toxicology letters
  3. Journal of chromatography. A
  4. Journal of natural products
  5. Die Pharmazie
View 2 additional sources
  1. Journal of ethnopharmacology
  2. Talanta

Aristolochic acid

  1. Iranian journal of kidney diseases
  2. Toxicology research
  3. Journal of chromatography. A
  4. Analytical and bioanalytical chemistry
  5. Scientific reports

Aristolactam I

  1. The Journal of pharmacy and pharmacology
  2. Journal of natural products

AA

  1. The Journal of pharmacy and pharmacology

AAI

  1. The Journal of pharmacy and pharmacology

AANA

  1. The Journal of pharmacy and pharmacology

ALI

  1. The Journal of pharmacy and pharmacology

Aristolactam bi

  1. Journal of natural products

Activities

Aristolochia has 3 reported activities identified across 2 scientific publications and several other databases. The most consistently reported activities include Nephrotoxic, Carcinogenic, Expectorant.

Activities reported in Aristolochia
Activity Supporting sources Consensus
Nephrotoxic 4 supporting sources ★★☆☆☆
Carcinogenic 3 supporting sources ★★☆☆☆
Expectorant 1 supporting sources ★☆☆☆☆

Nephrotoxic

  1. Journal of separation science
  2. Analytical chemistry
  3. Journal of agricultural and food chemistry
  4. Journal of pharmaceutical and biomedical analysis

Carcinogenic

  1. Analytical chemistry
  2. Journal of agricultural and food chemistry
  3. The Journal of biological chemistry

Expectorant

  1. Reviews on recent clinical trials

Medicinal Uses

Aristolochia has 15 reported medicinal uses identified across 2 scientific publications and several other databases. The most consistently reported uses include cancer, Balkan endemic nephropathy, TIN, analgesic, carcinogens.

Most Reported Uses

Use Sources Consensus
cancer Journal of ethnopharmacology (and other 3 sources) ★★☆☆☆
Balkan endemic nephropathy Journal of agricultural and food chemistry (and other 1 sources) ★☆☆☆☆
TIN The Journal of pharmacy and pharmacology (and other 1 sources) ★☆☆☆☆
analgesic Journal of ethnopharmacology (and other 1 sources) ★☆☆☆☆
carcinogens Environmental and molecular mutagenesis (and other 1 sources) ★☆☆☆☆
cold Reviews on recent clinical trials (and other 1 sources) ★☆☆☆☆
cough Journal of separation science (and other 1 sources) ★☆☆☆☆
diuretic Journal of ethnopharmacology (and other 1 sources) ★☆☆☆☆
kidney disease Journal of agricultural and food chemistry (and other 1 sources) ★☆☆☆☆
kidney failure EMBO reports (and other 1 sources) ★☆☆☆☆

Preparations

Preparations Sources Consensus
Aristolochia-containing products Scientific reports (and other 1 sources) ★☆☆☆☆
MeOH extract Biological & pharmaceutical bulletin (and other 1 sources) ★☆☆☆☆
capsule Molecules (Basel, Switzerland) (and other 1 sources) ★☆☆☆☆
crude drugs Scientific reports (and other 1 sources) ★☆☆☆☆
dried extracts Molecules (Basel, Switzerland) (and other 1 sources) ★☆☆☆☆
herbal extract Chemical research in toxicology (and other 1 sources) ★☆☆☆☆
pharmaceuatical capsule form of dry extract Molecules (Basel, Switzerland) (and other 1 sources) ★☆☆☆☆
powder Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (and other 1 sources) ★☆☆☆☆