birthwort
Aristolochia · Accepted scientific name
Scientific literature: Sparse (81 studies) · ★★☆☆☆
Birthwort, scientifically known as Aristolochia, is a genus of flowering plants valued historically in traditional medicine. While once used to treat inflammation and respiratory issues, modern science warns of its potent nephrotoxicity. Due to the risk of aristolochic acid, many species are now strictly regulated or avoided globally.
Names and Synonyms
Common Names
- birthwort
- dutchman's-pipe
- pipevines and birthworts
Scientific Names
Accepted name
AristolochiaSynonyms
- Hocquartia
- Hexaplectris
- Isotrema
- Isiphia
- Cardiolochia
- Ambuya
- Siphisia
- Guaco
- Endodeca
- Tropexa
- Einomeia
- Dictyanthes
- Diglosselis
- Pararistolochia
- Eimomenia
- Holostylis
- Plagistra
- Psophiza
- Pteriphis
Regional and Traditional Names
Spanish:
- Patitos
- Yerba de la virgen María
German:
- Pfeifenblumen
- Gespensterpflanze
- Pfeifenblume
- Osterluzei
- Pfeifenblumen
French:
- Aristoloche
- Aristoloches
- Aristoloche
Sources: Wikidata, Catalogue of Life
Taxonomical Classification
This plant belongs to the kingdom Plantae and the phylum Streptophyta, falling under the class Equisetopsida and subclass Magnoliidae. It is further classified within the order Piperales and the family Aristolochiaceae. Ultimately, this medicinal specimen is identified by the genus Aristolochia.
| Rank | Classification |
|---|---|
| Kingdom | Plantae |
| Phylum | Streptophyta |
| Class | Equisetopsida |
| Subclass | Magnoliidae |
| Order | Piperales |
| Family | Aristolochiaceae |
| Genus | Aristolochia |
Sources: The World Checklist of Vascular Plants (WCVP)
Distribution
This plant exhibits a specific geographical range across several regions of the European continent. In Northern Europe, its presence is documented in Denmark and Great Britain. The distribution extends further north to include the territories of Norway and Sweden. Additionally, its habitat reaches into Middle Europe, specifically within Austria. Together, these locations define the known environmental scope for the Aristolochia species.
| Region | Area |
|---|---|
| Northern Europe | Denmark |
| Northern Europe | Great Britain |
| Northern Europe | Norway |
| Northern Europe | Sweden |
| Middle Europe | Austria |
| Middle Europe | Belgium |
| Middle Europe | Czechia-Slovakia |
| Middle Europe | Germany |
| Middle Europe | Hungary |
| Middle Europe | Netherlands |
Sources: The World Checklist of Vascular Plants (WCVP)
Plant Parts
Aristolochia has 2 reported plant parts identified across 2 scientific publications and several other databases that are studied for medicinal purposes. The most consistently reported plant part include root, seed.
| Plant part | Supporting sources | Consensus |
|---|---|---|
| Root | 1 supporting sources | ★☆☆☆☆ |
| Seed | 1 supporting sources | ★☆☆☆☆ |
Root
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Seed
- Toxicology research
Chemicals
Aristolochia has 14 reported phytochemicals identified across 2 scientific publications and several other databases. The most consistently reported chemicals include Aristolochic acids, Aristolochic acid I, Aristolochic acid II, Aristolochic acid, Aristolactam I.
| Chemical | Supporting sources | Consensus |
|---|---|---|
| Aristolochic acids | 15 supporting sources | ★★★★★ |
| Aristolochic acid I | 8 supporting sources | ★★★★☆ |
| Aristolochic acid II | 7 supporting sources | ★★★★☆ |
| Aristolochic acid | 5 supporting sources | ★★★☆☆ |
| Aristolactam I | 2 supporting sources | ★☆☆☆☆ |
| AA | 1 supporting sources | ★☆☆☆☆ |
| AAI | 1 supporting sources | ★☆☆☆☆ |
| AANA | 1 supporting sources | ★☆☆☆☆ |
| ALI | 1 supporting sources | ★☆☆☆☆ |
| Aristolactam bi | 1 supporting sources | ★☆☆☆☆ |
Aristolochic acids
- Journal of ethnopharmacology
- Toxicology research
- Analytical chemistry
- Toxicology letters
- The Journal of pharmacy and pharmacology
View 10 additional sources
- Toxicology and applied pharmacology
- Journal of agricultural and food chemistry
- Journal of pharmaceutical and biomedical analysis
- Chemical research in toxicology
- International journal of molecular sciences
- Fitoterapia
- Environmental and molecular mutagenesis
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- Food chemistry
- Carcinogenesis
Aristolochic acid I
- Analytical chemistry
- Journal of separation science
- Toxicology letters
- Journal of chromatography. A
- Journal of natural products
View 3 additional sources
- Die Pharmazie
- Journal of ethnopharmacology
- Talanta
Aristolochic acid II
- Journal of separation science
- Toxicology letters
- Journal of chromatography. A
- Journal of natural products
- Die Pharmazie
View 2 additional sources
- Journal of ethnopharmacology
- Talanta
Aristolochic acid
- Iranian journal of kidney diseases
- Toxicology research
- Journal of chromatography. A
- Analytical and bioanalytical chemistry
- Scientific reports
Aristolactam I
- The Journal of pharmacy and pharmacology
- Journal of natural products
AA
- The Journal of pharmacy and pharmacology
AAI
- The Journal of pharmacy and pharmacology
AANA
- The Journal of pharmacy and pharmacology
ALI
- The Journal of pharmacy and pharmacology
Aristolactam bi
- Journal of natural products
Activities
Aristolochia has 3 reported activities identified across 2 scientific publications and several other databases. The most consistently reported activities include Nephrotoxic, Carcinogenic, Expectorant.
| Activity | Supporting sources | Consensus |
|---|---|---|
| Nephrotoxic | 4 supporting sources | ★★☆☆☆ |
| Carcinogenic | 3 supporting sources | ★★☆☆☆ |
| Expectorant | 1 supporting sources | ★☆☆☆☆ |
Nephrotoxic
- Journal of separation science
- Analytical chemistry
- Journal of agricultural and food chemistry
- Journal of pharmaceutical and biomedical analysis
Carcinogenic
- Analytical chemistry
- Journal of agricultural and food chemistry
- The Journal of biological chemistry
Expectorant
- Reviews on recent clinical trials
Medicinal Uses
Aristolochia has 15 reported medicinal uses identified across 2 scientific publications and several other databases. The most consistently reported uses include cancer, Balkan endemic nephropathy, TIN, analgesic, carcinogens.
Most Reported Uses
| Use | Sources | Consensus |
|---|---|---|
| cancer | Journal of ethnopharmacology (and other 3 sources) | ★★☆☆☆ |
| Balkan endemic nephropathy | Journal of agricultural and food chemistry (and other 1 sources) | ★☆☆☆☆ |
| TIN | The Journal of pharmacy and pharmacology (and other 1 sources) | ★☆☆☆☆ |
| analgesic | Journal of ethnopharmacology (and other 1 sources) | ★☆☆☆☆ |
| carcinogens | Environmental and molecular mutagenesis (and other 1 sources) | ★☆☆☆☆ |
| cold | Reviews on recent clinical trials (and other 1 sources) | ★☆☆☆☆ |
| cough | Journal of separation science (and other 1 sources) | ★☆☆☆☆ |
| diuretic | Journal of ethnopharmacology (and other 1 sources) | ★☆☆☆☆ |
| kidney disease | Journal of agricultural and food chemistry (and other 1 sources) | ★☆☆☆☆ |
| kidney failure | EMBO reports (and other 1 sources) | ★☆☆☆☆ |
Preparations
| Preparations | Sources | Consensus |
|---|---|---|
| Aristolochia-containing products | Scientific reports (and other 1 sources) | ★☆☆☆☆ |
| MeOH extract | Biological & pharmaceutical bulletin (and other 1 sources) | ★☆☆☆☆ |
| capsule | Molecules (Basel, Switzerland) (and other 1 sources) | ★☆☆☆☆ |
| crude drugs | Scientific reports (and other 1 sources) | ★☆☆☆☆ |
| dried extracts | Molecules (Basel, Switzerland) (and other 1 sources) | ★☆☆☆☆ |
| herbal extract | Chemical research in toxicology (and other 1 sources) | ★☆☆☆☆ |
| pharmaceuatical capsule form of dry extract | Molecules (Basel, Switzerland) (and other 1 sources) | ★☆☆☆☆ |
| powder | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (and other 1 sources) | ★☆☆☆☆ |