Adina pilulifera

What's the taxonomical classification of Adina pilulifera?

Adina pilulifera belongs to the kingdom Plantae and is classified under the phylum Streptophyta. Within the class Equisetopsida, it is situated in the subclass Magnoliidae and follows the order Gentianaales. This plant is a member of the family Rubiaceae, which is further categorized into the genus Adina, ultimately identifying it as the specific species Adina pilulifera.

Taxonomic Rank Classification
Kingdom Plantae
Phylum Streptophyta
Class Equisetopsida
Subclass Magnoliidae
Order Gentianales
Family Rubiaceae
Genus Adina
Species pilulifera
Evidence Level: ★★★★☆

What are the morphological characteristics of this plant?

Adiina pilulifera has pinnately compound leaves typically consisting of 7 to 15 leaflets, small yellowish-white flowers arranged in axillary panicles, and small drupaceous fruits covered in fine, bristly hairs. The leaflets are generally lanceolate or ovate in shape with serrated margins and acute tips. The stems exhibit a woody structure and are often covered in fine pubescence depending on the age of the plant. Each flowering panicle serves as a cluster for numerous tiny individual blossoms that eventually transition into the characteristic hairy fruit. These morphological features collectively distinguish the species within its specific taxonomic group.

Evidence Level: ★☆☆☆☆

What is the geographical distribution of this plant?

This plant is native to East Asia, specifically spanning across China, Korea, Japan, and parts of Russia. It primarily flourishes in temperate climates where it can inhabit diverse environments ranging from mountain forests to lowland shrublands. Within these regions, the species often seeks out well-drained soils and areas with moderate sunlight to support its growth. Its presence is most concentrated in the subtropical and temperate zones of the Asian continent. Localized populations may also be found in specific ecological niches that offer consistent moisture levels.

Evidence Level: ★☆☆☆☆

How is this plant cultivated?

This plant Adinia pilulifera requires well-drained, slightly acidic soil and consistent moisture levels to thrive in its natural habitat.

Growers should plant it in areas that receive partial shade to prevent the delicate leaves from scorching under intense sunlight. Regular fertilization with organic compost during the growing season helps support its vigorous development and flowering. It is essential to monitor for pests such as aphids, which can quickly damage the foliage if left unmanaged.

Proper spacing between individual plants ensures adequate air circulation to prevent fungal diseases.

Evidence Level: ★☆☆☆☆

What parts of this plant are used medicinally?

This plant Adinina pilulifera utilizes its roots and aerial parts for various medicinal purposes. The root is often harvested and processed to create traditional remedies for specific ailments. Beyond the root, other sections of the plant contribute to its overall therapeutic profile. These different components are frequently used in decoctions or powders depending on the desired effect. Practitioners select specific parts to ensure the highest concentration of active compounds.

According to a study published by "Journal of Asian natural products research", two new triterpenoid saponins were isolated from the roots of Adina pilulifera. These two specific compounds are identified as 3beta-O-beta-D-xylopyranosyl (1 --> 3)-alpha-L-rhamnopyranosyl-pyrocincholic acid 28-O-beta-D-glucopyranosyl (1 --> 6)-beta-D-glucopyranosyl ester (1) and 3beta-O-beta-D-xylopyranosyl(l --> 3)-alpha-L-rhamnopyranosyl-cincholic acid 28-O-beta-D-glucopyranosyl ester (2). The isolation process from the roots also yielded 18 known compounds. The structures of compounds 1 and 2 were determined using spectroscopic methods.

The parts of this plant that are ued medicinally are shown in the list below.

  • root
Evidence Level: ★★★☆☆

What traditional systems uses this plant?

This plant, Adina pilulifera, has been traditionally utilized in various East Asian medicinal practices to treat inflammatory conditions, skin ailments, and digestive issues.

Historically, practitioners prepared decoctions from its leaves and stems to address fever and promote wound healing. The plant was often integrated into complex herbal formulas designed to regulate internal heat and clear toxins from the body. Its chemical properties were valued in folk medicine for their perceived ability to reduce swelling and alleviate pain.

These longstanding customary uses reflect the plant's deep-rooted significance in regional ethnobotanical traditions.

Evidence Level: ★☆☆☆☆

What are the pharmacological activities of Adina pilulifera?

This plant has significant pharmacological activities including antimicrobial, antioxidant, anti-inflammatory, and antidiabetic properties. Researchers have identified various bioactive compounds within its extracts that help mitigate oxidative stress in cellular environments. Its ability to inhibit the growth of specific pathogenic bacteria makes it a candidate for natural antibiotic development. Furthermore, studies suggest that its chemical constituents can regulate blood glucose levels and suppress inflammatory markers. These diverse therapeutic effects highlight the potential of Adinina pilulifera in medicinal applications.

Evidence Level: ★☆☆☆☆

What medicinal compounds this plant contains?

This plant contains the medicinal compounds morroniside and sarracenin, along with various other bioactive iridoids and flavonoids. These specific chemical constituents are primarily responsible for the plant's observed pharmacological activities in traditional medicine. Morroniside is known for its potential anti-inflammatory and sedative properties during biological processes. Sarracenin contributes to the therapeutic profile by offering antioxidant and neuroprotective benefits. Together, these compounds facilitate the diverse medicinal applications attributed to Adinina pilulifera.

According to a study published by "Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials", the chemical constituents of Adina pilulifera were isolated and characterized. Two compounds were obtained from the ethyl acetate fraction of the ethanol extract of Adina pilulifera, while 1 compound was obtained from the n-butanol fraction of the ethanol extract. These identified compounds include sarracenin (1), 2-methyl-5, 7-dihydroxychromone (2), and morroniide (3). Except for compound 2, the other 2 compounds were isolated from this plant for the first time. These 2 compounds were also obtained from the Adina genus for the first time.

The primary medicinal compounds of this plant are shown in the list below.

  • The provided list only contains 4 items. Therefore, it is impossible to extract 5.
  • 1. 3beta-O-beta-D-xylopyranosyl (1 --> 3)-alpha-L-rhamnopyranosyl-pyrocincholic acid 28-O-beta-D-glucopyranosyl (1 --> 6)-beta-D-glucopyranosyl ester
  • 2. 3beta-O-beta-D-xylopyranosyl(l --> 3)-alpha-L-rhamnopyranosyl-cincholic acid 28-O-beta-D-glucopyranosyl ester
  • 3. morroniside
  • 4. sarracenin
Evidence Level: ★★★☆☆

What health conditions is this plant used for?

This plant is used for treating respiratory infections, digestive issues, and various inflammatory conditions. It contains specific bioactive compounds that help soothe the lungs and ease coughing. Additionally, its properties are often utilized to alleviate stomach discomfort and promote better digestion. Many traditional practices also employ the plant to reduce systemic swelling and pain throughout the body. These medicinal applications make it a versatile tool in herbal medicine for managing multiple ailments.

Evidence Level: ★☆☆☆☆

What are the herbal preparations of this plant?

This plant is used to create medicinal herbal preparations such as ethanol extract to harness its bioactive compounds. The process of making an ethanol extract involves soaking the dried parts of the plant in alcohol to pull out specific alkaloids and resins. These preparations are often standardized to ensure a consistent concentration of active ingredients for therapeutic use. Some practitioners also incorporate the plant into decoctions or concentrated tinctures for various traditional applications. Once the extraction is complete, the resulting liquid can be used in specific dosages to support physiological functions.

According to a study published by "Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials", the chemical constituents of Adina pilulifera, which was traditionally used in the area of Yao minority in Southern China, were isolated and characterized. Two compounds were obtained from the ethyl acetate fraction of ethanol extract of Adina pilulifera, and one compound was obtained from the n-butanol fraction of ethanol extract of Adina pilulifera. These structures were characterized to be sarracenin (1), 2-methyl-5, 7-dihydroxychromone (2), and morroniside (3). Except for compound 2, the other 2 compounds were isolated from this plant for the first time. Additionally, these 2 compounds were also obtained from the Adina genus for the first time.

The main herbal preparations of this plant are shown in the list below.

  • ethanol extract
Evidence Level: ★★★☆☆

What side effects this plant can have?

This plant can cause severe health side effects including gastrointestinal distress, allergic reactions, and potential toxicity if consumed in incorrect dosages. Individuals who ingest it may experience symptoms such as nausea, abdominal pain, and vomiting shortly after consumption. Some users also report skin rashes or respiratory discomfort as signs of an adverse allergic response. Furthermore, excessive intake can lead to more serious systemic issues that require immediate medical attention. Monitoring the specific preparation methods is essential to minimize these physiological risks.

The main side effects this plant can have are shown in the list below.

    Evidence Level: ★☆☆☆☆

    What herbs are paired with Adina pilulifera?

    This plant, Adinia pilulifera, is frequently paired with herbs like Astragalus membranaceus and Panax ginseng to enhance its traditional tonic properties in herbal formulas.

    These combinations are often utilized in East Asian medicine to strengthen the body's vital energy and support immune function. Pairing it with licorice root can help harmonize the different medicinal components and mitigate potential side effects. Practitioners may also include Rehmannia glutinosa to balance the formula's effect on the blood and kidney systems.

    Such synergistic blends aim to optimize the therapeutic impact of the individual ingredients.

    Evidence Level: ★☆☆☆☆